Cryotherapy versus Salicylic Acid with Monochloracetic Acid for the Treatment of Verrucae: A Randomised Controlled Trial
| ISRCTN | ISRCTN78267267 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN78267267 |
| Protocol serial number | N0530132857 |
| Sponsor | Department of Health |
| Funder | North Central London Research Consortium (UK) |
- Submission date
- 30/09/2004
- Registration date
- 30/09/2004
- Last edited
- 27/09/2011
- Recruitment status
- Stopped
- Overall study status
- Stopped
- Condition category
- Skin and Connective Tissue Diseases
Plain English summary of protocol
Not provided at time of registration
Contact information
Scientific
Podiatry Department
First Floor East Wing
St Pancras Hospital
4 St Pancras Way
London
NW1 0PE
United Kingdom
| Phone | +44 (0)20 7530 3871 |
|---|---|
| jules.day@virgin.net |
Study information
| Primary study design | Interventional |
|---|---|
| Study design | Randomised controlled trial |
| Secondary study design | Randomised controlled trial |
| Scientific title | |
| Study objectives | Verrucae, or warts, are a common, infectious and sometimes painful problem, but it is uncertain which is the most effective treatment. We plan to compare two commonly used treatments for warts: salicylic acid with monochloracetic acid or cryotherapy. We are interested to know how effective the two treatments are in cleaning up the warts and also how cost effective the two treatments are compared to one another. Patients will also be asked about acceptability with their treatment and possible side effects such as pain. |
| Ethics approval(s) | Not provided at time of registration |
| Health condition(s) or problem(s) studied | Skin and Connective Tissue Diseases: Warts |
| Intervention | Database analysis, Questionnaires, Randomised Controlled Trial - to compare: 1. Cryotherapy 2. Salicylic acid with monochloracetic acid For treatment of plantar warts August 2008: Trial stopped 2006. |
| Intervention type | Drug |
| Phase | Not Specified |
| Drug / device / biological / vaccine name(s) | Salicylic Acid with Monochloracetic Acid |
| Primary outcome measure(s) |
A recent systematic review has highlighted the uncertainty with respect to the optimal treatment of verrucae and warts (Gibbs Set et al, BMJ, 2002). Freezing warts using cryotherapy is widespread but there is little evidence showing it is effective. However, it may be relatively cost effective compared with chemical treatments in that fewer visits may be required to eradicate the condition. There is a need for a randomised controlled trial with a cost effectiveness analysis to ascertain which is the best approach. The evidence base would aid clinical decision makers and also health care managers in resource allocation |
| Key secondary outcome measure(s) |
Not provided at time of registration |
| Completion date | 31/08/2004 |
| Reason abandoned (if study stopped) | Problems with staffing. |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Not Specified |
| Sex | Not Specified |
| Target sample size at registration | 266 |
| Key inclusion criteria | Not provided at time of registration |
| Key exclusion criteria | Not provided at time of registration |
| Date of first enrolment | 29/10/2003 |
| Date of final enrolment | 31/08/2004 |
Locations
Countries of recruitment
- United Kingdom
- England
Study participating centre
NW1 0PE
United Kingdom
Results and Publications
| Individual participant data (IPD) Intention to share | No |
|---|---|
| IPD sharing plan summary | Not provided at time of registration |
| IPD sharing plan |
