Condition category
Infections and Infestations
Date applied
24/02/2007
Date assigned
21/03/2007
Last edited
01/02/2011
Prospective/Retrospective
Prospectively registered
Overall trial status
Completed
Recruitment status
No longer recruiting

Plain English Summary

Not provided at time of registration

Trial website

Contact information

Type

Scientific

Primary contact

Dr Peter Wilson

ORCID ID

Contact details

Room 231 Windeyer Institute of Medical Sciences
University College London Hospitals
46 Cleveland Street
London
W1T 4JF
United Kingdom
+44 (0)207 380 9516
peter.wilson@uclh.nhs.uk

Additional identifiers

EudraCT number

ClinicalTrials.gov number

Protocol/serial number

06/Q0502/91; UKCRN5751

Study information

Scientific title

Microfibre cleaning and contamination bioload detection technology versus standard cleaning in a critical care unit to reduce local contamination rates: a prospective randomised controlled trial

Acronym

Study hypothesis

Use of microfibre in a supervised programme of cleaning and decontamination in a critical care unit reduces local contamination rates and new colonisation of patients with Methicillin-resistant Staphylococcus aureus (MRSA) and other hospital pathogens in comparison with standard cleaning.

As of 22/10/2009 details of an observational follow-up study have been added to this record. All details of this follow-up study can be found under the relevant field with the title: 'Follow-up study'.

Follow-up study:
A follow-up observational study was performed in which four different pathways of transmission were assessed in order to inform current Departmental policies for ward cleaning.

Ethics approval

Joint UCL/UCLH Committee on the Ethics of Human Research approved on the 9th November 2006 (ref: 06/Q0502/91)

Study design

Prospective randomised controlled cohort study

Primary study design

Observational

Secondary study design

Cohort study

Trial setting

Hospitals

Trial type

Prevention

Patient information sheet

Not available in web format, please use the contact details below to request a patient information sheet

Condition

Hospital-acquired infection

Intervention

A total environmental cleaning system based on microfibre and governed by standard operating procedures designed to achieve microbiological control of the entire near-patient environment.

Follow-up study:
This follow-up study will study intensively the bacterial reservoirs within a critical care and a general ward. In addition the movement of staff from one contact surface to another will be audited together with hand hygiene. Direct observation will be used but entirely anonymised. The project will also address spread of nosocomial pathogens in the environment by cleaning materials and airborne transmission.

Intervention type

Other

Phase

Not Applicable

Drug names

Primary outcome measures

Proportion of the pooled results of all environmental swabs taken from bed areas on each day showing a target pathogen, e.g. MRSA

Secondary outcome measures

The rate of new acquisition by patients of MRSA and other target pathogens

Overall trial start date

02/04/2007

Overall trial end date

05/04/2008

Reason abandoned

Eligibility

Participant inclusion criteria

All patients admitted to the critical care units of UCLH and Royal Free Hospitals. The critical care units are randomised to microfibre or standard cleaning. There is no patient intervention other than recording any infections developed.

Participant type

Patient

Age group

Other

Gender

Both

Target number of participants

3 intensive care units, 14000 patient days, 4000 patients

Participant exclusion criteria

Does not meet inclusion criteria

Recruitment start date

02/04/2007

Recruitment end date

05/04/2008

Locations

Countries of recruitment

United Kingdom

Trial participating centre

Room 231 Windeyer Institute of Medical Sciences
London
W1T 4JF
United Kingdom

Sponsor information

Organisation

National Institute for Health Research (NIHR) (UK)

Sponsor details

PO Box 407
Teddington
TW11 0XX
United Kingdom
+44 (0)20 8943 8990
Joanne.Martin@nihr-ccf.org.uk

Sponsor type

Government

Website

http://www.nihr-ccf.org.uk

Funders

Funder type

Government

Funder name

National Institute for Health Research (NIHR) (UK) - HCAI Technology Innovation Programme (ref: 0140028)

Alternative name(s)

Funding Body Type

Funding Body Subtype

Location

Results and Publications

Publication and dissemination plan

Not provided at time of registration

Intention to publish date

Participant level data

Not provided at time of registration

Results - basic reporting

Publication summary

1. 2011 results in http://www.ncbi.nlm.nih.gov/pubmed/21242793

Publication citations

  1. Results

    Wilson AP, Smyth D, Moore G, Singleton J, Jackson R, Gant V, Jeanes A, Shaw S, James E, Cooper B, Kafatos G, Cookson B, Singer M, Bellingan G, The impact of enhanced cleaning within the intensive care unit on contamination of the near-patient environment with hospital pathogens: a randomized crossover study in critical care units in two hospitals., Crit. Care Med., 2011, 39, 4, 651-658, doi: 10.1097/CCM.0b013e318206bc66.

Additional files

Editorial Notes