Plain English Summary
Not provided at time of registration
Trial website
Contact information
Type
Scientific
Primary contact
Prof Frank Kee
ORCID ID
Contact details
QUB Centre For Clinical and Population Science
1st Floor Mulhouse building
Royal Victoria Hospital
Grosvenor road
Belfast
BT12 6BA
United Kingdom
+44 (0)28 90632746
f.kee@qub.ac.uk
Additional identifiers
EudraCT number
ClinicalTrials.gov number
Protocol/serial number
COM/2371/03
Study information
Scientific title
Acronym
Northern Ireland Public Access Defibrillation (NIPAD)
Study hypothesis
Training laypersons such as first responders and police officers to carry and use automated external defibrillators to attend the scene of out-of-hospital sudden cardiac arrests will result in the resuscitation of additional patients by a reduction in the response time compared to the existing emergency medical service response.
Ethics approval
Ethics approval received from the Northern Ireland Research Ethics Committee on the 26th March 2003 (ref: 47/03).
Study design
An observational study for one year followed by an intervention using public access defibrillation on the cohort
Primary study design
Interventional
Secondary study design
Cohort study
Trial setting
Not specified
Trial type
Prevention
Patient information sheet
Condition
Out-of-hospital sudden cardiac arrest
Intervention
Training lay cardiac first responders and police officers to carry and use automated external defibrillators in response to sudden out-of-hospital cardiac arrest in fixed and mobile locations.
Intervention type
Other
Phase
Not Specified
Drug names
Primary outcome measure
1. Survival after hospital discharge following out-of-hospital sudden cardiac arrest
2. Cost-effectiveness of public access defibrillation in the study areas
Secondary outcome measures
1. Reduction in response time compared to existing emergency medical services
2. Return of spontaneous circulation
3. The modelling of the results to Northern Ireland as a whole using a spatial modelling approach
4. The modelling of the effectiveness and cost-effectiveness of public access defibrillation across Northern Ireland
Overall trial start date
01/01/2004
Overall trial end date
03/04/2006
Reason abandoned (if study stopped)
Eligibility
Participant inclusion criteria
All patients with a presumed out-of-hospital sudden cardiac arrest over the age of 14 in Antrim, Ballymena, Magherafelt and North and West Belfast district council areas of Northern Ireland.
Participant type
Patient
Age group
Adult
Gender
Both
Target number of participants
300,000 people in study area, expected 300 cardiac arrests
Participant exclusion criteria
Out-of-hospital sudden deaths due to non-cardiac causes including trauma, drowning, overdose, poisoning and fire.
Recruitment start date
01/01/2004
Recruitment end date
03/04/2006
Locations
Countries of recruitment
United Kingdom
Trial participating centre
QUB Centre For Clinical and Population Science
Belfast
BT12 6BA
United Kingdom
Sponsor information
Organisation
The Research and Development Office for Health and Personal Social Services in Northern Ireland (UK)
Sponsor details
R&D Office
12-22 Linenhall street
Belfast
BT2 8BS
United Kingdom
+44 (0)28 90553617
joanne.O'Neill@rdo.n-i.nhs.uk
Sponsor type
Government
Website
Funders
Funder type
Government
Funder name
The Research and Development Office for Health and Personal Social Services in Northern Ireland (UK)
Alternative name(s)
Funding Body Type
Funding Body Subtype
Location
Results and Publications
Publication and dissemination plan
Not provided at time of registration
Intention to publish date
Participant level data
Not provided at time of registration
Basic results (scientific)
Publication list
Results in http://www.ncbi.nlm.nih.gov/pubmed/17540690
Publication citations
-
Results
Cairns KJ, Hamilton AJ, Marshall AH, Moore MJ, Adgey AA, Kee F, The obstacles to maximising the impact of public access defibrillation: an assessment of the dispatch mechanism for out-of-hospital cardiac arrest., Heart, 2008, 94, 3, 349-353, doi: 10.1136/hrt.2006.109785.