The contribution of race as a determining factor in the development of glaucoma
| ISRCTN | ISRCTN09311359 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN09311359 |
| Secondary identifying numbers | N/A |
- Submission date
- 07/12/2009
- Registration date
- 02/02/2010
- Last edited
- 11/07/2013
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Eye Diseases
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Plain English summary of protocol
Not provided at time of registration
Contact information
Mr Kin Sheng Lim
Scientific
Scientific
St. Thomas' Hospital
Westminster Bridge Road
London
SE1 7EH
United Kingdom
| Phone | +44 (0)20 7188 2289 |
|---|---|
| shenglim@gmail.com |
Study information
| Study design | Prospective observational longitudinal non-randomised study |
|---|---|
| Primary study design | Observational |
| Secondary study design | Non randomised controlled trial |
| Study setting(s) | Hospital |
| Study type | Other |
| Participant information sheet | Not available in web format, please use contact details below to request a patient information sheet |
| Scientific title | The contribution of race as a determining factor in the development of Primary Open Angle Glaucoma (POAG): An observational trial |
| Study acronym | ADS (aqueous dynamic study) |
| Study objectives | The distribution of aqueous production rate and the out-flow facility in patients from different racial groups with POAG. Primary open angle glaucoma is defined as glaucomatous optic neuropathy together with an IOP >21 mmHg on at least one occasion and visual field defects (using the 24-2 test pattern on a Humphrey Field Analyzer) and a gonioscopic angle width of 3 or 4 and normal in appearance. |
| Ethics approval(s) | St. Thomas' Hospital Research Ethics Committee, Approved on 14 August 2007, REC ref number: 07/Q0702/61 |
| Health condition(s) or problem(s) studied | Primary open angle glaucoma (POAG) |
| Intervention | Patients will receive standard treatment and care. Therefore, there is no intervention, just some extra measurements which used to be part of routine clinical examinations. Additional measurements will be carried out using pnuematonometry, fluorophotometry and Schiotz tonography machines |
| Intervention type | Other |
| Primary outcome measure | Outflow facility determined Comparison of results before and 3 months after treatment |
| Secondary outcome measures | 1. Anterior chamber depth 2. Intraocular pressure Comparison of results before and 3 months after treatment |
| Overall study start date | 15/10/2007 |
| Completion date | 31/05/2010 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Other |
| Sex | Both |
| Target number of participants | 30 patients from each of the following race groups with or without POAG: African origin and White Caucasian |
| Key inclusion criteria | 1. Males or Females between ages 18 and 90 2. Availability to participate in all aspects of the study 3. Willingness to participate in a study 4. Ability to undergo accurate fluorophotometry and tonography |
| Key exclusion criteria | 1. History of intraocular surgery or keratorefractive surgery 2. Systemic medications which affects aqueous production, such as beta adrenergic blockers, steroids 3. Fluorescein allergy |
| Date of first enrolment | 15/10/2007 |
| Date of final enrolment | 31/05/2010 |
Locations
Countries of recruitment
- England
- United Kingdom
Study participating centre
St. Thomas' Hospital
London
SE1 7EH
United Kingdom
SE1 7EH
United Kingdom
Sponsor information
Guy's and St. Thomas NHS Foundation Trust (UK)
Hospital/treatment centre
Hospital/treatment centre
c/o Karen Ignatian
Research and Development
3rd Floor Conybeare House
Guy's House
Guy's Hospital
St .Thomas Street
London
SE1 9RT
England
United Kingdom
| Phone | +44 (0)20 7188 5731 |
|---|---|
| karen.ignatian@gstt.nhs.uk | |
| Website | http://www.guysandstthomas.nhs.uk/ |
"ROR" |
https://ror.org/00j161312 |
Funders
Funder type
Charity
Eye Hope Charity (UK)
No information available
Results and Publications
| Intention to publish date | |
|---|---|
| Individual participant data (IPD) Intention to share | No |
| IPD sharing plan summary | Not provided at time of registration |
| Publication and dissemination plan | Not provided at time of registration |
| IPD sharing plan |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Results article | results | 09/12/2011 | Yes | No |
