Contact information
Type
Scientific
Primary contact
Mr Kin Sheng Lim
ORCID ID
Contact details
St. Thomas' Hospital
Westminster Bridge Road
London
SE1 7EH
United Kingdom
+44 (0)20 7188 2289
shenglim@gmail.com
Additional identifiers
EudraCT number
ClinicalTrials.gov number
Protocol/serial number
N/A
Study information
Scientific title
The contribution of race as a determining factor in the development of Primary Open Angle Glaucoma (POAG): An observational trial
Acronym
ADS (aqueous dynamic study)
Study hypothesis
The distribution of aqueous production rate and the out-flow facility in patients from different racial groups with POAG.
Primary open angle glaucoma is defined as glaucomatous optic neuropathy together with an IOP >21 mmHg on at least one occasion and visual field defects (using the 24-2 test pattern on a Humphrey Field Analyzer) and a gonioscopic angle width of 3 or 4 and normal in appearance.
Ethics approval
St. Thomas' Hospital Research Ethics Committee, Approved on 14 August 2007, REC ref number: 07/Q0702/61
Study design
Prospective observational longitudinal non-randomised study
Primary study design
Observational
Secondary study design
Non randomised controlled trial
Trial setting
Hospitals
Trial type
Other
Patient information sheet
Not available in web format, please use contact details below to request a patient information sheet
Condition
Primary open angle glaucoma (POAG)
Intervention
Patients will receive standard treatment and care. Therefore, there is no intervention, just some extra measurements which used to be part of routine clinical examinations.
Additional measurements will be carried out using pnuematonometry, fluorophotometry and Schiotz tonography machines
Intervention type
Other
Phase
Not Applicable
Drug names
Primary outcome measure
Outflow facility determined
Comparison of results before and 3 months after treatment
Secondary outcome measures
1. Anterior chamber depth
2. Intraocular pressure
Comparison of results before and 3 months after treatment
Overall trial start date
15/10/2007
Overall trial end date
31/05/2010
Reason abandoned (if study stopped)
Eligibility
Participant inclusion criteria
1. Males or Females between ages 18 and 90
2. Availability to participate in all aspects of the study
3. Willingness to participate in a study
4. Ability to undergo accurate fluorophotometry and tonography
Participant type
Patient
Age group
Other
Gender
Both
Target number of participants
30 patients from each of the following race groups with or without POAG: African origin and White Caucasian
Participant exclusion criteria
1. History of intraocular surgery or keratorefractive surgery
2. Systemic medications which affects aqueous production, such as beta adrenergic blockers, steroids
3. Fluorescein allergy
Recruitment start date
15/10/2007
Recruitment end date
31/05/2010
Locations
Countries of recruitment
United Kingdom
Trial participating centre
St. Thomas' Hospital
London
SE1 7EH
United Kingdom
Sponsor information
Organisation
Guy's and St. Thomas NHS Foundation Trust (UK)
Sponsor details
c/o Karen Ignatian
Research and Development
3rd Floor Conybeare House
Guy's House
Guy's Hospital
St .Thomas Street
London
SE1 9RT
United Kingdom
+44 (0)20 7188 5731
karen.ignatian@gstt.nhs.uk
Sponsor type
Hospital/treatment centre
Website
Funders
Funder type
Charity
Funder name
Eye Hope Charity (UK)
Alternative name(s)
Funding Body Type
Funding Body Subtype
Location
Results and Publications
Publication and dissemination plan
Not provided at time of registration
Intention to publish date
Participant level data
Not provided at time of registration
Basic results (scientific)
Publication list
2011 results in http://www.ncbi.nlm.nih.gov/pubmed/21980001
Publication citations
-
Results
Beltran-Agullo L, Alaghband P, Rashid S, Gosselin J, Obi A, Husain R, Lim KS, Comparative human aqueous dynamics study between black and white subjects with glaucoma., Invest. Ophthalmol. Vis. Sci., 2011, 52, 13, 9425-9430, doi: 10.1167/iovs.10-7130.