Diet and risk of cancer and other diseases in the UK Biobank

ISRCTN ISRCTN10125697
DOI https://doi.org/10.1186/ISRCTN10125697
Secondary identifying numbers UK Biobank project number 3037
Submission date
06/10/2017
Registration date
30/11/2017
Last edited
17/06/2019
Recruitment status
No longer recruiting
Overall study status
Completed
Condition category
Cancer
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data

Plain English summary of protocol

Background and study aims
While there are many ideas about the effects of diet on the risk of developing cancer and other diseases, understanding of the health effects of diet is far from complete. The aim of this study is to examine the effects of diet on the risk of developing cancer and other diseases, including but not limited to cardiovascular (heart) diseases, metabolic disorders, bone health, and gastrointestinal (digestive system) diseases.

Who can participate?
Men and women who live within reasonable travelling distance (about 25 km) of one of the 22 assessment centres

What does the study involve?
Participants attend a clinical visit during which lifestyle and physical measurements are taken. Their health data records are used to assess the links between various dietary factors (e.g. nutrients and food intakes or habitual diet groups) and incidence or mortality (death) from cancer or other diseases, with follow-up until December 2014 in the first instance, and with additional follow-up as this information is collected.

What are the possible benefits and risks of participating?
There are no expected benefits or risks of participation except for the time required for the clinical visit (about 90 minutes).

Where is the study run from?
University of Oxford (UK)

When is the study starting and how long is it expected to run for?
September 2004 to December 2014

Who is funding the study?
1. Medical Research Council (UK)
2. Wellcome Trust (UK)

Who is the main contact?
Dr Kathryn Bradbury

Study website

Contact information

Dr Kathryn Bradbury
Scientific

Cancer Epidemiology Unit, Richard Doll Building
University of Oxford, Old Road Campus
Oxford
OX3 7LF
United Kingdom

Study information

Study designLongitudinal cohort study
Primary study designObservational
Secondary study designLongitudinal study
Study setting(s)Other
Study typeOther
Participant information sheet Not available in web format, please use the contact details to request a patient information sheet
Scientific titleDiet and risk of cancer and other diseases in the UK Biobank: a longitudinal cohort study
Study objectivesTo develop a research programme on diet in UK Biobank, to study the effects of diet on the risk of cancer and other diseases.
Ethics approval(s)Permission for access to patient records for recruitment was approved by the Patient Information Advisory Group (subsequently replaced by the National Information Governance Board for Health and Social Care) in England and Wales, and the Community Health Index Advisory Group in Scotland, 17/06/2011, ref: 11/NW/0382
Health condition(s) or problem(s) studiedCancer and other diseases or conditions, including but not limited to cardiovascular diseases, metabolic disorders, bone health, anaemia, gastrointestinal disease, and intermediate markers of health related to the above diseases, such as anthropometry, physical characteristics and biomarkers
InterventionThe trialists will be assessing the association between various dietary factors (e.g. nutrients and food intakes or habitual diet groups) and incidence or mortality from cancer or other diseases, including but not limited to cardiovascular diseases, metabolic disorders, bone health, and gastrointestinal diseases, and characterisation of intermediate markers, either as cross-sectional analyses or longitudinal analyses with follow-up until December 2014 in the first instance, and subsequently with additional follow-up as this information is accrued.
Intervention typeNot Specified
Primary outcome measureIncidence or mortality from cancer, measured via record linkage to hospital records or death registries longitudinally for indefinite periods at whichever time point the event occurs
Secondary outcome measures1. Incidence or mortality from other diseases, including but not limited to cardiovascular diseases, metabolic disorders, bone health, and gastrointestinal diseases, measured via record linkage to hospital records or death registries longitudinally for indefinite periods at whichever time point the event occurs
2. Intermediate markers: anthropometric measures (bio-impedance and DEXA scans), bone mineral density (heel bone ultrasound), blood pressure and pulse rate (blood pressure monitor), grip strength (dynamometer), and blood counts (various assays), measured at baseline
Overall study start date14/09/2004
Completion date31/12/2014

Eligibility

Participant type(s)All
Age groupAdult
SexBoth
Target number of participants500000
Total final enrolment500000
Key inclusion criteriaMen and women who lived within reasonable travelling distance (~25 km) of one of the 22 assessment centres
Key exclusion criteriaNo pre-specified exclusion criteria
Date of first enrolment13/03/2006
Date of final enrolment01/10/2010

Locations

Countries of recruitment

  • England
  • United Kingdom

Study participating centre

Cancer Epidemiology Unit, University of Oxford
OX3 7LF
United Kingdom

Sponsor information

Cancer Epidemiology Unit, University of Oxford
University/education

Richard Doll Building
University of Oxford
Old Road Campus
Oxford
OX3 7LF
England
United Kingdom

ROR logo "ROR" https://ror.org/052gg0110

Funders

Funder type

Research council

Medical Research Council
Government organisation / National government
Alternative name(s)
Medical Research Council (United Kingdom), UK Medical Research Council, MRC
Location
United Kingdom
Wellcome Trust
Private sector organisation / International organizations
Location
United Kingdom
Girdlers New Zealand Health Research Council

No information available

Results and Publications

Intention to publish date31/10/2017
Individual participant data (IPD) Intention to shareYes
IPD sharing plan summaryAvailable on request
Publication and dissemination planFor further details of the UK Biobank study protocol and recruitment methods, please visit http://www.ukbiobank.ac.uk/resources/. Other resources will not be publicly available but researchers are welcome to send in enquiries to the corresponding author. Multiple publications planned in peer-reviewed journals from October 2017 onwards.
IPD sharing planUK Biobank is an open access resource. Bona fide researchers can obtain further information or apply to use the UK Biobank dataset by registering and applying at http://www.ukbiobank.ac.uk/register-apply/.

Study outputs

Output type Details Date created Date added Peer reviewed? Patient-facing?
Results article results 01/06/2018 Yes No
Results article results 01/08/2019 17/06/2019 Yes No

Editorial Notes

17/06/2019: Publication reference and total final enrolment added.
06/06/2018: Publication reference added.