Contact information
Type
Scientific
Primary contact
Dr Ian Needleman
ORCID ID
Contact details
Department of Periodontology
Eastman Dental Institute for Oral Health Care Sciences
University College London
256 Gray's Inn Road
London
WC1X 8LD
United Kingdom
+44 (0) 20 7915 2340
i.needleman@eastman.ucl.ac.uk
Additional identifiers
EudraCT number
ClinicalTrials.gov number
Protocol/serial number
N/A
Study information
Scientific title
Acronym
Study hypothesis
Not provided at time of registration.
Ethics approval
Not provided at time of registration.
Study design
Randomised controlled trial
Primary study design
Interventional
Secondary study design
Randomised controlled trial
Trial setting
Not specified
Trial type
Not Specified
Patient information sheet
Condition
Periodontology
Intervention
1. Non-surgical periodontal therapy plus twice daily 20 mg doxycycline for 3 months
2. Non-surgical periodontal therapy plus twice daily placebo for 3 months
Intervention type
Other
Phase
Not Specified
Drug names
Primary outcome measures
Not provided at time of registration.
Secondary outcome measures
Not provided at time of registration.
Overall trial start date
15/10/2000
Overall trial end date
15/10/2005
Reason abandoned
Eligibility
Participant inclusion criteria
1. Smokers unable to quit
2. Moderate-severe chronic periodontitis
3. Age 30-70
Participant type
Patient
Age group
Not Specified
Gender
Not Specified
Target number of participants
Not provided at time of registration.
Participant exclusion criteria
Not provided at time of registration.
Recruitment start date
15/10/2000
Recruitment end date
15/10/2005
Locations
Countries of recruitment
United Kingdom
Trial participating centre
Department of Periodontology
London
WC1X 8LD
United Kingdom
Sponsor information
Organisation
CollaGenex Pharmaceuticals Inc. (USA)
Sponsor details
41 University Drive
Newtown
PA 18940
United States of America
Sponsor type
Industry
Website
Funders
Funder type
Industry
Funder name
Mainly self-supported: design, conduct, analysis and reporting are independent of industry. Biochemical analyses funded by CollaGenex Inc.
Alternative name(s)
Funding Body Type
Funding Body Subtype
Location
Results and Publications
Publication and dissemination plan
Not provided at time of registration
Intention to publish date
Participant level data
Not provided at time of registration
Results - basic reporting
Publication summary
2007 results in http://www.ncbi.nlm.nih.gov/pubmed/17324155
Publication citations
-
Results
Needleman I, Suvan J, Gilthorpe MS, Tucker R, St George G, Giannobile W, Tonetti M, Jarvis M, A randomized-controlled trial of low-dose doxycycline for periodontitis in smokers., J. Clin. Periodontol., 2007, 34, 4, 325-333, doi: 10.1111/j.1600-051X.2007.01058.x.