Condition category
Surgery
Date applied
12/09/2003
Date assigned
12/09/2003
Last edited
07/09/2012
Prospective/Retrospective
Retrospectively registered
Overall trial status
Completed
Recruitment status
No longer recruiting

Plain English Summary

Not provided at time of registration

Trial website

Contact information

Type

Scientific

Primary contact

Mr AJ Brooks

ORCID ID

Contact details

Department of Surgery
E Floor West Block
University Hospital
Nottingham
NG7 2UH
United Kingdom
+44 (0)115 9249924
adambrooks@btopenworld.com

Additional identifiers

EudraCT number

ClinicalTrials.gov number

Protocol/serial number

N0192122289

Study information

Scientific title

Acronym

Study hypothesis

Is tissue carbon dioxide a valuable marker of liver cell function during liver resection surgery?

Ethics approval

Not provided at time of registration

Study design

Randomised controlled trial

Primary study design

Interventional

Secondary study design

Randomised controlled trial

Trial setting

Not specified

Trial type

Not Specified

Patient information sheet

Condition

Surgery: Liver resection

Intervention

1. Hyperventilated to a preclamp end tidal CO2 of 3.5 kPa and the clamp will be applied until the tissue CO2 is 10 kPa (approx 10 min)
2. Standard practice

Intervention type

Procedure/Surgery

Phase

Not Specified

Drug names

Primary outcome measures

Comparison of tissue carbon dioxide and indocyanine green clearance.

Secondary outcome measures

Not provided at time of registration

Overall trial start date

01/09/2002

Overall trial end date

31/08/2003

Reason abandoned

Eligibility

Participant inclusion criteria

Not provided at time of registration

Participant type

Patient

Age group

Not Specified

Gender

Not Specified

Target number of participants

20

Participant exclusion criteria

Not provided at time of registration

Recruitment start date

01/09/2002

Recruitment end date

31/08/2003

Locations

Countries of recruitment

United Kingdom

Trial participating centre

Department of Surgery
Nottingham
NG7 2UH
United Kingdom

Sponsor information

Organisation

Department of Health (UK)

Sponsor details

Richmond House
79 Whitehall
London
SW1A 2NL
United Kingdom

Sponsor type

Government

Website

http://www.doh.gov.uk

Funders

Funder type

Government

Funder name

Queen's Medical Centre University Hospital NHS Trust (UK)

Alternative name(s)

Funding Body Type

Funding Body Subtype

Location

Results and Publications

Publication and dissemination plan

Not provided at time of registration

Intention to publish date

Participant level data

Not provided at time of registration

Results - basic reporting

Publication summary

1. 2007 results in http://www.ncbi.nlm.nih.gov/pubmed/17512550

Publication citations

  1. Results

    Brooks AJ, Hammond JS, Girling K, Beckingham IJ, The effect of hepatic vascular inflow occlusion on liver tissue pH, carbon dioxide, and oxygen partial pressures: defining the optimal clamp/release regime for intermittent portal clamping., J. Surg. Res., 2007, 141, 2, 247-251, doi: 10.1016/j.jss.2006.10.054.

Additional files

Editorial Notes