Contact information
Type
Scientific
Primary contact
Mr AJ Brooks
ORCID ID
Contact details
Department of Surgery
E Floor West Block
University Hospital
Nottingham
NG7 2UH
United Kingdom
+44 (0)115 9249924
adambrooks@btopenworld.com
Additional identifiers
EudraCT number
ClinicalTrials.gov number
Protocol/serial number
N0192122289
Study information
Scientific title
Acronym
Study hypothesis
Is tissue carbon dioxide a valuable marker of liver cell function during liver resection surgery?
Ethics approval
Not provided at time of registration
Study design
Randomised controlled trial
Primary study design
Interventional
Secondary study design
Randomised controlled trial
Trial setting
Not specified
Trial type
Not Specified
Patient information sheet
Condition
Surgery: Liver resection
Intervention
1. Hyperventilated to a preclamp end tidal CO2 of 3.5 kPa and the clamp will be applied until the tissue CO2 is 10 kPa (approx 10 min)
2. Standard practice
Intervention type
Procedure/Surgery
Phase
Not Specified
Drug names
Primary outcome measures
Comparison of tissue carbon dioxide and indocyanine green clearance.
Secondary outcome measures
Not provided at time of registration
Overall trial start date
01/09/2002
Overall trial end date
31/08/2003
Reason abandoned
Eligibility
Participant inclusion criteria
Not provided at time of registration
Participant type
Patient
Age group
Not Specified
Gender
Not Specified
Target number of participants
20
Participant exclusion criteria
Not provided at time of registration
Recruitment start date
01/09/2002
Recruitment end date
31/08/2003
Locations
Countries of recruitment
United Kingdom
Trial participating centre
Department of Surgery
Nottingham
NG7 2UH
United Kingdom
Sponsor information
Organisation
Department of Health (UK)
Sponsor details
Richmond House
79 Whitehall
London
SW1A 2NL
United Kingdom
Sponsor type
Government
Website
Funders
Funder type
Government
Funder name
Queen's Medical Centre University Hospital NHS Trust (UK)
Alternative name(s)
Funding Body Type
Funding Body Subtype
Location
Results and Publications
Publication and dissemination plan
Not provided at time of registration
Intention to publish date
Participant level data
Not provided at time of registration
Results - basic reporting
Publication summary
1. 2007 results in http://www.ncbi.nlm.nih.gov/pubmed/17512550
Publication citations
-
Results
Brooks AJ, Hammond JS, Girling K, Beckingham IJ, The effect of hepatic vascular inflow occlusion on liver tissue pH, carbon dioxide, and oxygen partial pressures: defining the optimal clamp/release regime for intermittent portal clamping., J. Surg. Res., 2007, 141, 2, 247-251, doi: 10.1016/j.jss.2006.10.054.