Plain English Summary
Background and study aims:
During laparoscopic surgery, small bowel paralysis facilitates surgical conditions. This is especially important when complex surgery, with intestinal suturing or stapling, is performed. Both opioids and hypnotic agents might influence small bowel peristalsis. The effects of opioids on intestinal motility (intestinal contractions) are well studied and are known to result in intestinal paralysis. With reference to the effects of hypnotics on intestinal motility, data are scarce. Our group recently studied the effect of different volatile (inhaled) anaesthetics on intestinal motility during laparoscopic surgery requiring small bowel anastomosis (removal of a piece of bowel followed by the joining up of the remaining sections). There were statistically significant less peristaltic waves (involuntary muscle movements in the bowel) in the sevoflurane-based anaesthesia group compared to the desflurane-based anaesthesia group. Stimulation of the irritant Transient Receptor Potential channel A1 (TRPA1) was offered to explain the increased intestinal motility observed with desflurane compared to sevoflurane. Given the fact that propofol is a direct modulator of TRPA1, we hypothesized that propofol increases intestinal motility during anaesthesia compared to sevoflurane.
Who can participate?
All patients presenting for gastric bypass surgery at the AZ Groeninge Hospital
What does the study involve?
Patients are randomized in two study groups. One group receives a propofol based anesthesia and one group receives a sevoflurane based anesthesia. At a specific time point during surgery, intestinal motility is assessed by the surgeon and scrub nurse.
What are the possible benefits and risks of participating?
Benefits include an advancement in better understanding of the effects of anesthetics on intestinal motility. No risks are involved in participating in the study, besides the risk involved with anesthesia and surgery.
Where is the study run from?
AZ Groeninge Hospital, Kortrijk (Belgium)
When is the study starting and how long is it expected to run for?
April 2013 to December 2013
Who is funding the study?
AZ Groeninge Hospital (Belgium)
Who is the main contact?
The effect of propofol and sevofurane on intestinal motility during laparoscopic surgery: a single blind randomized controlled trial.
Propofol anaesthesia increases intestinal motility during laparoscopic gastric bypass surgery compared to sevoflurane based anaesthesia.
AZ Groeninge Ethical Committee, 04/03/2013, ref: 13006
Single-centre prospective randomized controlled single-blind two-arm interventional study
Primary study design
Secondary study design
Randomised controlled trial
Patient information sheet
Not available in web format, please use contact details to request a participant information sheet
Observation of intestinal motility during laparoscopic surgery
1. Group TIVA (Total Intravenous Anesthesia) will receive a propofol based anesthesia
2. Group Sevo will receive a sevoflurane based anesthesia
Primary outcome measures
Intestinal motility measured by visual count of peristaltic waves
Secondary outcome measures
Overall trial start date
Overall trial end date
Participant inclusion criteria
All patients presenting for laparoscopic Roux en Y bariatric surgery at AZ Groeninge Hospital
Target number of participants
Participant exclusion criteria
Recruitment start date
Recruitment end date
Countries of recruitment
Trial participating centre
Loofstraat 43 8500 Kortrijk
Department of Anesthesia, AZ Groeninge Hospital (Belgium)
Funding Body Type
Funding Body Subtype
Results and Publications
Publication and dissemination plan
Publication in Peer reviewed Anaesthesia Journal (eg. Acta Anaesthesiologica Scandinavica)
Intention to publish date
Participant level data
Available on request
Results - basic reporting
2016 results in: http://www.ncbi.nlm.nih.gov/pubmed/26806956