Contact information
Type
Scientific
Primary contact
Ms Claudia Wheeler-Kingshott
ORCID ID
Contact details
The Institute of Neurology
Queen Square
London
WC1N 3BG
United Kingdom
-
c.wheeler-kingshott@ion.ucl.ac.uk
Additional identifiers
EudraCT number
ClinicalTrials.gov number
Protocol/serial number
5580
Study information
Scientific title
Development of novel magnetic resonance imaging (MRI) techniques for neurological applications
Acronym
Study hypothesis
Quantitative magnetic resonance imaging (MRI) techniques may provide additional information in the understanding of several neurological and psychiatric disorders. The development of some of these techniques is still incomplete and the interpretation of results in pathology is thus limited. Scanning healthy subjects and analysing their data will help in making the scanning techniques suitable for clinical applications. This is an ongoing process of continual testing and optimisation.
Ethics approval
MREC, ref: 05/Q0502/101
Study design
Single-centre non-randomised observational diagnosis and screening study
Primary study design
Observational
Secondary study design
Non randomised controlled trial
Trial setting
Hospitals
Trial type
Screening
Patient information sheet
Not available in web format, please use contact details to request a participant information sheet
Condition
Topic: Neurological; Subtopic: Neurological (all Subtopics); Disease: Nervous system disorders
Intervention
Routine MRI examinations only provide qualitative images of the brain. Quantitative MRI techniques, such as MR spectroscopy (MRS), magnetisation transfer imaging (MTI), diffusion imaging (DI), perfusion imaging (PI) and relaxometry can be particularly useful in the investigation of the pathological substrate of several diseases. Their usefulness is well documented in the literature; however, their application is somehow limited by technical problems.
Intervention type
Other
Phase
Not Applicable
Drug names
Primary outcome measures
1. Magnetic resonance imaging (MRI)
2. MR spectroscopy (MRS)
3. Magnetisation transfer imaging (MTI)
4. Diffusion imaging (DI)
5. Perfusion imaging (PI)
Secondary outcome measures
Not provided at time of registration
Overall trial start date
01/01/2006
Overall trial end date
31/07/2009
Reason abandoned
Eligibility
Participant inclusion criteria
Not provided at time of registration
Participant type
Patient
Age group
Not Specified
Gender
Not Specified
Target number of participants
Planned sample size: 150
Participant exclusion criteria
Not provided at time of registration
Recruitment start date
01/01/2006
Recruitment end date
31/07/2009
Locations
Countries of recruitment
United Kingdom
Trial participating centre
The Institute of Neurology
London
WC1N 3BG
United Kingdom
Sponsor information
Organisation
University College London (UCL) (UK)
Sponsor details
UCL Biomedicine Research & Development Unit
Maple House
149 Tottenham Court Road
London
W1T 7NF
United Kingdom
Sponsor type
University/education
Website
Funders
Funder type
Charity
Funder name
Multiple Sclerosis Society (UK)
Alternative name(s)
MS Society
Funding Body Type
private sector organisation
Funding Body Subtype
professional associations and societies
Location
United Kingdom
Results and Publications
Publication and dissemination plan
Not provided at time of registration
Intention to publish date
Participant level data
Not provided at time of registration
Results - basic reporting
Publication summary