Development of novel magnetic resonance imaging (MRI) techniques for neurological applications

ISRCTN	ISRCTN13036842
DOI	https://doi.org/10.1186/ISRCTN13036842
Secondary identifying numbers	5580

Submission date: 21/05/2010
Registration date: 21/05/2010
Last edited: 08/08/2016

Recruitment status: No longer recruiting
Overall study status: Completed
Condition category: Nervous System Diseases

Prospectively registered

Protocol

Statistical analysis plan

Results

Individual participant data

Record updated in last year

Plain English summary of protocol

Not provided at time of registration

Contact information

Ms Claudia Wheeler-Kingshott
Scientific

The Institute of Neurology
Queen Square
London
WC1N 3BG
United Kingdom

Email	c.wheeler-kingshott@ion.ucl.ac.uk

Study information

Study design	Single-centre non-randomised observational diagnosis and screening study
Primary study design	Observational
Secondary study design	Non randomised controlled trial
Study setting(s)	Hospital
Study type	Screening
Participant information sheet	Not available in web format, please use contact details to request a participant information sheet
Scientific title	Development of novel magnetic resonance imaging (MRI) techniques for neurological applications
Study objectives	Quantitative magnetic resonance imaging (MRI) techniques may provide additional information in the understanding of several neurological and psychiatric disorders. The development of some of these techniques is still incomplete and the interpretation of results in pathology is thus limited. Scanning healthy subjects and analysing their data will help in making the scanning techniques suitable for clinical applications. This is an ongoing process of continual testing and optimisation.
Ethics approval(s)	MREC, ref: 05/Q0502/101
Health condition(s) or problem(s) studied	Topic: Neurological; Subtopic: Neurological (all Subtopics); Disease: Nervous system disorders
Intervention	Routine MRI examinations only provide qualitative images of the brain. Quantitative MRI techniques, such as MR spectroscopy (MRS), magnetisation transfer imaging (MTI), diffusion imaging (DI), perfusion imaging (PI) and relaxometry can be particularly useful in the investigation of the pathological substrate of several diseases. Their usefulness is well documented in the literature; however, their application is somehow limited by technical problems.
Intervention type	Other
Primary outcome measure	1. Magnetic resonance imaging (MRI) 2. MR spectroscopy (MRS) 3. Magnetisation transfer imaging (MTI) 4. Diffusion imaging (DI) 5. Perfusion imaging (PI)
Secondary outcome measures	Not provided at time of registration
Overall study start date	01/01/2006
Completion date	31/07/2009

Eligibility

Participant type(s)	Patient
Age group	Not Specified
Sex	Not Specified
Target number of participants	Planned sample size: 150
Key inclusion criteria	Not provided at time of registration
Key exclusion criteria	Not provided at time of registration
Date of first enrolment	01/01/2006
Date of final enrolment	31/07/2009

Locations

Countries of recruitment

England
United Kingdom

Study participating centre

The Institute of Neurology

London
WC1N 3BG
United Kingdom

Sponsor information

University College London (UCL) (UK)
University/education

UCL Biomedicine Research & Development Unit
Maple House
149 Tottenham Court Road
London
W1T 7NF
England
United Kingdom

Website	http://www.ucl.ac.uk/
"ROR"	https://ror.org/02jx3x895

Funders

Funder type

Charity

Multiple Sclerosis Society (UK)
Private sector organisation / Associations and societies (private and public)

Alternative name(s): Multiple Sclerosis Society of Great Britain and Northern Ireland, The MS Society, MS Society UK, Multiple Sclerosis Society UK, MS Society
Location: United Kingdom

Results and Publications

Intention to publish date
Individual participant data (IPD) Intention to share	No
IPD sharing plan summary	Not provided at time of registration
Publication and dissemination plan	Not provided at time of registration
IPD sharing plan

Editorial Notes

09/08/2016: No publications found, verifying study status with principal investigator.