The effect of retrograde autologous priming of cardiopulmonary bypass circuit on jugular bulb venous oxygen saturation compared with conventional priming: a prospective randomised comparative study
| ISRCTN | ISRCTN14583192 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN14583192 |
| Secondary identifying numbers | N0436117978 |
- Submission date
- 12/09/2003
- Registration date
- 12/09/2003
- Last edited
- 26/02/2020
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Surgery
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Record updated in last year
Plain English summary of protocol
Not provided at time of registration
Contact information
Dr H Pauli
Scientific
Scientific
Department of Anaesthesia
Leeds General Infirmary
Leeds
LS1 3EX
United Kingdom
| Phone | +44 (0)113 392 6672 |
|---|---|
| abc@email.com |
Study information
| Study design | Randomised active controlled parallel group trial |
|---|---|
| Primary study design | Interventional |
| Secondary study design | Randomised controlled trial |
| Study setting(s) | Hospital |
| Study type | Treatment |
| Scientific title | The effect of retrograde autologous priming of cardiopulmonary bypass circuit on jugular bulb venous oxygen saturation compared with conventional priming: a prospective randomised comparative study |
| Study objectives | We propose to assess and compare the coupling of cerebral metabolism and cerebral blood flow in patients undergoing coronary artery bypass grafting using moderate hypothermic cardiopulmonary bypass primed with retrograde autologous or conventional priming. |
| Ethics approval(s) | Not provided at time of registration |
| Health condition(s) or problem(s) studied | Coronary artery bypass grafting (CABG) |
| Intervention | Randomised controlled trial. Random allocation to: 1. Conventional priming of cardiopulmonary bypass circuit 2. Retrograde autologous priming of bypass circuit |
| Intervention type | Procedure/Surgery |
| Primary outcome measure | To compare SjvO2 values immediately after establishing full cardiopulmonary bypass pump flow. |
| Secondary outcome measures | Further SjvO2 values and Lactate - Oxygen Indices. |
| Overall study start date | 31/08/2002 |
| Completion date | 31/08/2003 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Adult |
| Sex | Both |
| Target number of participants | 20 |
| Key inclusion criteria | 20 Patients scheduled to undergo first time coronary artery bypass grafting will be recruited. They will be American Society of Anaesthesiologist grade III or less. |
| Key exclusion criteria | 1. History of cerebrovascular disease 2. Diabetes mellitus 3. Body weight less than 60 kg 4. Haemoglobin level of less than 11g/dl 5. Refusal to receive blood products |
| Date of first enrolment | 31/08/2002 |
| Date of final enrolment | 31/08/2003 |
Locations
Countries of recruitment
- England
- United Kingdom
Study participating centre
Department of Anaesthesia
Leeds
LS1 3EX
United Kingdom
LS1 3EX
United Kingdom
Sponsor information
Department of Health (UK)
Government
Government
Richmond House
79 Whitehall
London
SW1A 2NL
United Kingdom
| Website | http://www.doh.gov.uk |
|---|
Funders
Funder type
Hospital/treatment centre
Leeds Teaching Hospitals NHS Trust (UK)
No information available
Results and Publications
| Intention to publish date | |
|---|---|
| Individual participant data (IPD) Intention to share | No |
| IPD sharing plan summary | Not provided at time of registration |
| Publication and dissemination plan | Not provided at time of registration |
| IPD sharing plan |
Editorial Notes
26/02/2020: No publications found. All search options exhausted.
