Condition category
Circulatory System
Date applied
21/02/2006
Date assigned
29/03/2006
Last edited
08/11/2011
Prospective/Retrospective
Retrospectively registered
Overall trial status
Completed
Recruitment status
No longer recruiting

Plain English Summary

Not provided at time of registration

Trial website

Contact information

Type

Scientific

Primary contact

Dr Narasimharajapura Rajendra

ORCID ID

Contact details

Dept of Clinical Pharmacology
Level 7
Ninewells Hospital
Dundee
DD1 9SY
United Kingdom
+44 (0)1382 496355

Additional identifiers

EudraCT number

ClinicalTrials.gov number

Protocol/serial number

JUS002

Study information

Scientific title

Acronym

Study hypothesis

Xanthine oxidase inhibition in chronic stable angina improves endothelial function.

Ethics approval

Approved by the Regional Ethics Committee on 08/11/2005, reference number: 05/S1401/101

Study design

Randomised double blind placebo-controlled crossover trial

Primary study design

Interventional

Secondary study design

Randomised controlled trial

Trial setting

Not specified

Trial type

Treatment

Patient information sheet

Condition

Chronic stable angina

Intervention

Allopurinol versus placebo

Intervention type

Drug

Phase

Not Specified

Drug names

Allopurinol

Primary outcome measures

Change in endothelial function as assessed by:
1. Flow-mediated dilatation
2. Forearm venous occlusion plethysmography

Secondary outcome measures

Changes in brain natriuretic peptide (BNP)

Overall trial start date

05/01/2006

Overall trial end date

02/04/2008

Reason abandoned

Eligibility

Participant inclusion criteria

1. Documented coronary artery disease
2. Chronic stable angina

Participant type

Patient

Age group

Adult

Gender

Both

Target number of participants

88

Participant exclusion criteria

1. Left ventricular systolic dysfunction
2. Renal failure
3. Concomitant warfarin therapy
4. Allergy to allopurinol

Recruitment start date

05/01/2006

Recruitment end date

02/04/2008

Locations

Countries of recruitment

United Kingdom

Trial participating centre

Dept of Clinical Pharmacology
Dundee
DD1 9SY
United Kingdom

Sponsor information

Organisation

University of Dundee (UK)

Sponsor details

The Nethergate
University of Dundee
Dundee
DD1 4HN
United Kingdom

Sponsor type

University/education

Website

Funders

Funder type

Charity

Funder name

The British Heart Foundation (UK)

Alternative name(s)

Funding Body Type

Funding Body Subtype

Location

Results and Publications

Publication and dissemination plan

Not provided at time of registration

Intention to publish date

Participant level data

Not provided at time of registration

Results - basic reporting

Publication summary

2011 results in http://www.ncbi.nlm.nih.gov/pubmed/21835317

Publication citations

  1. Results

    Rajendra NS, Ireland S, George J, Belch JJ, Lang CC, Struthers AD, Mechanistic insights into the therapeutic use of high-dose allopurinol in angina pectoris., J. Am. Coll. Cardiol., 2011, 58, 8, 820-828, doi: 10.1016/j.jacc.2010.12.052.

Additional files

Editorial Notes