Relationship between native riverine prawns, intermediate host snails and schistosomiasis prevalence in two river systems in Côte d’Ivoire
| ISRCTN | ISRCTN16000867 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN16000867 |
| Secondary identifying numbers | N/A |
- Submission date
- 20/12/2017
- Registration date
- 18/01/2018
- Last edited
- 11/02/2022
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Infections and Infestations
Plain English summary of protocol
Background and study aims
Schistosomiasis is an infection caused by a parasitic worm that lives in fresh water in tropical and subtropical areas. The parasite can infect both humans and fresh water snails. In Côte d’Ivoire, schistosomiasis is endemic (regularly found) and the national control strategy emphasizes preventive chemotherapy (medication). However, this strategy does not protect patients from being infected again and so additional control measures are needed. The aim of this study is to explore the association between the snails that carry schistosomiasis, freshwater prawns that might act as their natural predators, and schistosomiasis among school-aged children and adults.
Who can participate?
Children aged 9–12 and adults aged 20–55 who live in participating villages in Côte d’Ivoire
What does the study involve?
All human-water contact points are visited four times over a 14-month period once every season in each of the 24 villages, in order to collect samples of snails and prawns. Participants give stool and urine samples which are checked for schistosomiasis parasite eggs.
What are the possible benefits and risks of participating?
Participants who are found to be infected are treated with the drug praziquantel. Villages where the prevalence of schistosomiasis is over 20% are all treated with praziquantel by the national schistosomiasis control programme. Praziquantel has few adverse events (e.g. mild abdominal pain and headache).
Where is the study run from?
1. Swiss Tropical and Public Health Institute (Switzerland)
2. Université Félix Houphouët-Boigny (Côte d’Ivoire)
When is the study starting and how long is it expected to run for?
May 2015 to December 2016
Who is funding the study?
The Bill & Melinda Gates Foundation through the Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) based at the University of Georgia
Who is the main contact?
Prof. Juerg Utzinger
Contact information
Scientific
Socinstrasse 57
Basel
4002
Switzerland
 ORCID ID |
0000-0001-6885-0798 |
|---|
Study information
| Study design | Ecological study, including a single cross-sectional parasitological survey in humans and four cross-sectional surveys pertaining to prawns and snails |
|---|---|
| Primary study design | Observational |
| Secondary study design | Ecological study |
| Study setting(s) | Other |
| Study type | Other |
| Participant information sheet | Not available in web format, please use the contact details to request a patient information sheet |
| Scientific title | Relationship between native riverine prawns, intermediate host snails and schistosomiasis prevalence in two river systems in Côte d’Ivoire |
| Study objectives | Native riverine prawns (Macrobrachium) act as natural predators of schistosomiasis intermediate host snails (Bulinus sp and Biomphalaria), and hence influence the transmission of schistosomiasis. |
| Ethics approval(s) | Comité National d’Éthique et de la Recherche, Ministère de la Santé et de Lutte contre le SIDA, 22/01/2015, ref: 114/MSLS/CNER-dkn |
| Health condition(s) or problem(s) studied | Schistosoma mansoni infection, Schistosoma haematobium infection |
| Intervention | Twenty-four villages located in two hydrological systems of Côte d’Ivoire will be the selected for the current study. The villages will be situated within a 3 km radius from the main river in the two hydrological system. The villages will be separated from each other by at least 5 km. All human-water contact points will be visited four times over a 14 months study period, once every season in each of the 24 localities. Intermediate host snails will be sampled by two experienced malacologists during 15 min using kitchen sieves and forceps. Prawns will be collected using an electric fishing device. A total of 150 individuals (100 pupils aged 9–12 years and 50 adults aged 20–55 years) will be invited to give stool and urine samples during a single cross sectional survey. Stool samples will be subjected to duplicate Kato-Katz thick smear, and slides quantitatively examined under microscope for Schistosoma mansoni eggs and urine filtration method for to determine Schistosoma haematobium eggs. |
| Intervention type | Other |
| Primary outcome measure | Schistosoma mansoni and S. haematobium infection status, assessed with the Kato-Katz and urine filtration methods, respectively, in a cross-sectional survey conducted from 21/01/2016 to 29/01/2016 |
| Secondary outcome measures | 1. The presence and number of riverine prawns, collected using an electric fishing device, determined in four surveys once every season: 01/10/2015-12/10/2015 07/04/2016-19/04/2016 19/07/2016-31/07/2016 04/12/2016-15/12/2016 2. The presence and number of intermediate host snails, sampled using kitchen sieves and forceps, determined in four surveys once every season: 01/10/2015-12/10/2015 07/04/2016-19/04/2016 19/07/2016-31/07/2016 04/12/2016-15/12/2016 |
| Overall study start date | 28/05/2015 |
| Completion date | 15/12/2016 |
Eligibility
| Participant type(s) | Mixed |
|---|---|
| Age group | Mixed |
| Sex | Both |
| Target number of participants | 3600 |
| Total final enrolment | 3600 |
| Key inclusion criteria | 1. Written informed consent signed by adults (aged 20-55 years) and parents/guardian of children (aged 9-12 years) and oral assent by children 2. Able and willing to provide a single urine sample at the baseline cross-sectional survey 3. No known allergy to study medication (i.e. praziquantel) |
| Key exclusion criteria | 1. No written informed consent by adults and parents/guardian on behalf of their children 2. Recent use of anthelminthic drug (within past 4 weeks) |
| Date of first enrolment | 21/01/2016 |
| Date of final enrolment | 29/01/2016 |
Locations
Countries of recruitment
- Côte d'Ivoire
- Switzerland
Study participating centres
Basel
4051
Switzerland
22 BP 770
Abidjan
22
Côte d'Ivoire
Sponsor information
Research organisation
Socinstrasse 57
Basel
4051
Switzerland
| Website | https://www.swisstph.ch/en/ |
|---|---|
"ROR" |
https://ror.org/03adhka07 |
Funders
Funder type
Charity
No information available
Results and Publications
| Intention to publish date | 31/12/2018 |
|---|---|
| Individual participant data (IPD) Intention to share | No |
| IPD sharing plan summary | Data sharing statement to be made available at a later date |
| Publication and dissemination plan | The study protocol has not yet been published but will be submitted to BMC Public Health and available online in the next few months. The trialists intend to publish the study results in the peer-reviewed (whenever possible open-access) literature before the end of 2018. |
| IPD sharing plan | The data sharing plans for the current study are unknown and will be made available at a later date. |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Results article | 01/11/2018 | 11/02/2022 | Yes | No |
Editorial Notes
11/02/2022: Publication reference and total final enrolment added.
