Plain English Summary
Background and study aims
There is lots of information about e-cigarettes online, especially on social media. This type of information may be hindering efforts to reduce tobacco smoking and in turn result in more cases of cancer. Researchers would like to find out how information about e-cigarettes impacts on people’s attitudes towards using e-cigarettes. They have created a questionnaire designed to find out what people think about e-cigarettes after seeing different types of information about e-cigarettes.
Who can participate?
Current smokers aged 18 years or older, living in the US or the UK who do not currently use e-cigarettes or a vaping device.
What does the study involve?
Participants are asked to complete an online questionnaire about e-cigarette use. Participants are then shown some information related to the health impacts of e-cigarettes on separate screens. Following the information messages, they are then asked to complete a second questionnaire about e-cigarette use.
What are the possible benefits and risks of participating?
There are no risks associated with taking part in this study. The researchers added a debrief summary of the latest evidence relating to the relative/absolute harms of e-cigarettes and also provided a link to stopping smoking services in their region. The results from this study will help researchers to better understand how information impacts on people’s beliefs about e-cigarettes/vapes, which in turn could help with smoking cessation programmes and reduce cancer.
Where is the study run from?
University of Bristol (UK)
When is the study starting and how long is it expected to run for?
March 2019 to December 2019
Who is funding the study?
Cancer Research UK
Who is the main contact?
Dr Caroline Wright
Examining prevalence, mechanism of action and effects of e-cigarette misinformation on Twitter
Exposure to misinformation about e-cigarette harms on Twitter among current smokers in the United States (US) and the United Kingdom (UK) will result in increased misperceptions of e-cigarette harms.
Approved 05/08/2019, additional amendment approved 11/12/2019, further amendment approved 30/04/2020, University of Bristol Faculty of Health Sciences Research Ethics Committee (FREC, University of Bristol Faculty of Health Sciences, First Floor South, Senate House, Tyndall Avenue, Bristol, BS8 1TH, UK; +44 (0)117 331 8197, +44 (0)117 928 9089; Liam.McKervey@bristol.ac.uk), ref: 80323
Randomized controlled experiment using an online survey instrument
Primary study design
Secondary study design
Randomised controlled trial
Patient information sheet
See attached file
Prevention of cancer through smoking cessation
Following eligibility screening and providing informed consent, participants first complete baseline measures of study outcomes. Participants are randomized into one of four experimental conditions in a 1:1:1:1 ratio using the in-built least-fill randomiser function on the Prodege survey platform:
1. Messages that e-cigarettes are as or more harmful than regular cigarettes
2. Messages that e-cigarettes are completely harmless
3. Messages conveying uncertainty about e-cigarettes
4. Control: messages about physical activity
Participants are told they would be shown different types of health-related information and asked about their opinions about e-cigarettes. After randomization to a condition, they view one tweet at a time in random order and are asked brief questions (perceived effectiveness, liking and sharing, and their emotions) about each tweet. They next complete post-test measures of the study outcomes, current tobacco use behaviours, health information exposure and (social) media use, and socio-demographic and psychological characteristics.
Primary outcome measure
Measured pre-exposure (baseline) and post-exposure:
1. Smoking cessation contemplation ladder: participants provide a score reflecting their likelihood of quitting smoking from 0 (no thought of quitting) to 10 (taking action to quit)
2. Risk perceptions of combustible tobacco: participants were asked to give a score reflecting the likelihood that smoking combustible tobacco will result in lung cancer, heart disease, mouth or throat cancer, chronic obstructive pulmonary disorder (COPD) and stroke from 1 (extremely unlikely) to 5 (extremely likely)
3. Risk perceptions of electronic cigarettes: participants were asked to give a score reflecting the likelihood that smoking combustible tobacco will result in lung cancer, heart disease, mouth or throat cancer, chronic obstructive pulmonary disorder (COPD) and stroke from 1 (extremely unlikely) to 5 (extremely likely)
4. Perceived relative harm of e-cigarettes compared to smoking regular cigarettes: participants were asked: Compared to smoking regular cigarettes, would you say that e-cigarettes/vapes are much less harmful (1) - much more harmful (5).
5. Intentions to purchase electronic cigarettes in the next month: How probable is it that you will purchase an e-cigarette/vape in the next month? 0 (no chance) to 10 (certain)
6. Knowledge about electronic cigarettes: participants’ given statement about e-cigarettes e.g. E-cigarettes do not contain any of the toxic chemicals that can be found in regular cigarettes and asked if the statement is (1) true, (20) false, or (3) don’t know.
Secondary outcome measures
1. Perceived effectiveness of exposure condition: participants' were asked after viewing each exposure to rate how much they disagree or agree with the following statements about the message they just saw: this message is worth remembering, this message grabbed my attention, this message is powerful, this message is informative, this message is meaningful to me, this message is convincing.
2. Intentions to reply/retweet/like/share message (Tweets): participants were asked after each exposure are you likely to reply/retweet/like/share this message.
3. Emotional responses to exposure condition: participants were asked after each exposure: when thinking about e-cigarettes, does the message you just saw make you feel: scared, hopeful, worried, happy, angry, relieved
4. Self-efficacy to quit smoking, participants were asked at the end of the questionnaire: How confident are you that you can quit using tobacco? Not at all confident, Not very confident , Somewhat confident , Confident , Very confident & Completely confident
5. Prior exposure to e-cigarette misinformation, participants were asked at the end of the questionnaire
6. Level of trust for information on e-cigarettes: participants were asked at the end of the questionnaire
7. Exposure to conflicting information about e-cigarettes: participants were asked at the end of the questionnaire
8. Information seeking about e-cigarettes: participants were asked at the end of the questionnaire
9. Perceived addictiveness of cigarettes and e-cigarettes: participants were asked at the end of the questionnaire
10. Social media and internet use: participants were asked at the end of the questionnaire
11. Self-identity; participants were asked: How much do you agree or disagree with each of the following statements: I am very sensitive to criticism by others. Answers: strongly disagree (1) - strongly agree (5). Measured once, post-exposure.
12. Epistemic beliefs about facts and science: participants' were asked a series of questions about their intuition, need to see evidence and beliefs about how truth/facts and power/politics interact. Measured once, post-exposure.
Overall trial start date
Overall trial end date
Reason abandoned (if study stopped)
Participant inclusion criteria
1. Participants’ must be current smokers
2. Aged 18 years or older
3. Living in either the US or UK
4. Who are not currently using e-cigarettes or a vaping device
Target number of participants
Total final enrolment
Participant exclusion criteria
1. Not aged 18 years or older
2. Did not live in either the US or UK
3. Were not current smokers
4. Were currently using e-cigarettes or vaping device
Recruitment start date
Recruitment end date
Countries of recruitment
Trial participating centre
University of Bristol
Bristol Medical School Barley House Oakfield Grove
University of Bristol
University of Bristol Faculty of Health Sciences
First Floor South
+44 (0)117 928 9089
Cancer Research UK
Funding Body Type
private sector organisation
Funding Body Subtype
Results and Publications
Publication and dissemination plan
Planned publications in high impact journals.
IPD sharing statement
Following the completion of the research and subsequent publications, instructions for accessing the data will be made available on Dr Caroline Wright's homepage on the University of Bristol website (and CRUK website if requested).
Requests for data will be fielded by Dr Caroline Wright (firstname.lastname@example.org) and shared with other researchers, provided a satisfactory data-sharing agreement has been completed by the requesting researcher. The data-sharing agreement will impose appropriate limitations on the secondary use of the data, with reference to the 'Samples and Data for Cancer Research: Template for Access Policy Development' document. The researchers also plan to upload the data to a data repository site.
Intention to publish date
Participant level data
Available on request
Basic results (scientific)