Standard versus rapid initiation of anti-hypertensive therapy
| ISRCTN | ISRCTN16286916 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN16286916 |
| Secondary identifying numbers | N0237101856 |
- Submission date
- 12/09/2003
- Registration date
- 12/09/2003
- Last edited
- 16/09/2014
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Circulatory System
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Record updated in last year
Plain English summary of protocol
Not provided at time of registration
Contact information
Dr Shirley Hulme
Scientific
Scientific
Diabetes Centre
Whiston Hospital
Prescot
L35 5DR
United Kingdom
| Phone | +44 (0)151 426 1600 |
|---|
Study information
| Study design | Randomised controlled trial, open design |
|---|---|
| Primary study design | Interventional |
| Secondary study design | Randomised controlled trial |
| Study setting(s) | Not specified |
| Study type | Treatment |
| Scientific title | |
| Study objectives | The aim of the study is to evaluate the impact on blood pressure control, patient satisfaction and well being and adherence to medication of conventional gradual titration of anti-hypertensive treatment versus rapid introduction and dose escalation of four anti-hypertensive agents in subjects with diabetic nephropathy. |
| Ethics approval(s) | Not provided at time of registration |
| Health condition(s) or problem(s) studied | Cardiovascular: Hypertension |
| Intervention | Standard versus rapid initiation of anti-hypertensive therapy |
| Intervention type | Other |
| Primary outcome measure | 1. Patient adherence to treatment 2. Blood pressure 3. Proteinuria 4. Adverse events 5. Treatment satisfaction |
| Secondary outcome measures | Not provided at time of registration |
| Overall study start date | 01/11/2001 |
| Completion date | 01/04/2004 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Not Specified |
| Sex | Not Specified |
| Target number of participants | 24 |
| Key inclusion criteria | 24 subjects recruited from new patients entering the nephropathy clinic |
| Key exclusion criteria | Not provided at time of registration |
| Date of first enrolment | 01/11/2001 |
| Date of final enrolment | 01/04/2004 |
Locations
Countries of recruitment
- England
- United Kingdom
Study participating centre
Diabetes Centre
Prescot
L35 5DR
United Kingdom
L35 5DR
United Kingdom
Sponsor information
Department of Health (UK)
Government
Government
Richmond House
79 Whitehall
London
SW1A 2NL
United Kingdom
| Website | http://www.doh.gov.uk |
|---|
Funders
Funder type
Government
St Helens and Knowsley Hospitals NHS Trust (UK)
No information available
Results and Publications
| Intention to publish date | |
|---|---|
| Individual participant data (IPD) Intention to share | No |
| IPD sharing plan summary | Not provided at time of registration |
| Publication and dissemination plan | Not provided at time of registration |
| IPD sharing plan |
