Additional identifiers
EudraCT number
ClinicalTrials.gov number
Protocol/serial number
NHD1
Study information
Scientific title
A trial to compare radiotherapy alone with radiotherapy followed by chemotherapy in the treatment of non-Hodgkin's lymphoma
Acronym
Study hypothesis
Not provided at time of registration
Ethics approval
Not provided at time of registration
Study design
Randomised controlled trial
Primary study design
Interventional
Secondary study design
Randomised controlled trial
Trial setting
Hospitals
Trial type
Treatment
Patient information sheet
Not available in web format, please use the contact details below to request a patient information sheet
Condition
Lymphoma (non-Hodgkin's)
Intervention
1. Group A: Radical radiotherapy, 30 Gy in 15 fractions over 3 weeks
2. Group B: Radical radiotherapy, 30 Gy in 15 fractions over 3 weeks followed 1 month later by chemotherapy. Chemotherapy with chlorambucil for 14 consecutive days repeated every 28 days for 2 years.
Intervention type
Mixed
Phase
Drug names
Primary outcome measures
Not provided at time of registration
Secondary outcome measures
Not provided at time of registration
Overall trial start date
01/01/1990
Overall trial end date
03/11/1992
Reason abandoned
Eligibility
Participant inclusion criteria
1. Aged 15-65 years
2. Proven non-Hodgkin's disease with good pathology involving nodes, Waldeyer's ring is also included provided that nodes are also involved
3. Stage I or II
Participant type
Patient
Age group
Adult
Gender
Both
Target number of participants
Not provided at time of registration
Participant exclusion criteria
Patients with abdominal nodes only are excluded
Recruitment start date
01/01/1990
Recruitment end date
03/11/1992
Locations
Countries of recruitment
United Kingdom
Trial participating centre
MRC Clinical Trials Unit
London
NW1 2DA
United Kingdom
Sponsor information
Organisation
Cancer Research UK (CRUK) (UK)
Sponsor details
PO Box 123
Lincoln's Inn Fields
London
WC2A 3PX
United Kingdom
+44 (0)207 317 5186
kate.law@cancer.org.uk
Sponsor type
Charity
Website
Funders
Funder type
Charity
Funder name
Cancer Research UK
Alternative name(s)
Funding Body Type
private sector organisation
Funding Body Subtype
other non-profit
Location
United Kingdom
Results and Publications
Publication and dissemination plan
Not provided at time of registration
Intention to publish date
Participant level data
Not provided at time of registration
Results - basic reporting
Publication summary