Kinetics of left ventricular strains and untwist during the transitions from rest to exercise
| ISRCTN | ISRCTN18219450 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN18219450 |
| Secondary identifying numbers | KINETICS01 |
- Submission date
- 05/12/2017
- Registration date
- 23/03/2018
- Last edited
- 13/01/2022
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Circulatory System
Plain English summary of protocol
Background and study aims
During the transitions from rest to exercise, oxygen uptake is limited by muscle oxygen delivery, which directly depends of the response of the cardiorespiratory system (heart and lungs) at the start of the exercise. Endurance training is known for allowing a faster cardiac (heart) adaptation. However, data about cardiac adaptation during the transition from rest to exercise are limited to heart rate, stroke volume and cardiac output. Today, new advances in echocardiography based on speckle tracking can be used to measure regional left ventricular (LV) strains and twist. The aim of this study is to assess regional LV strains and twist of endurance trained cyclists compared to sedentary adults at the onset of dynamic exercise.
Who can participate?
Young male cyclists and healthy volunteers aged 18-35
What does the study involve?
The participants perform five similar constant work-load exercises on an exercise bicycle (target heart rate: 130 bpm), in order to measure myocardial (heart muscle) strains with speckle-tracking echocardiography (a type of ultrasound scan). Heart function is assessed every 15 seconds during the first minute and then every 30 seconds up until 240 seconds.
What are the possible benefits and risks of participating?
Participants may benefit from a clinical examination performed by a cardiologist. Exercises are performed at submaximal intensities (corresponding to 130 bpm). Therefore, there are no risks for participants.
Where is the study run from?
University of Avignon (France)
When is the study starting and how long is it expected to run for?
January 2015 to December 2017
Who is funding the study?
University of Avignon (France)
Who is the main contact?
1. Dr Stephane Nottin
stephane.nottin@univ-avignon.fr
2. Dr Omar Izem
omizem@gmail.com
Contact information
Scientific
74 rue Louis Pasteur
Avignon
84000
France
| Phone | +33 (0)490162931 |
|---|---|
| stephane.nottin@univ-avignon.fr |
Study information
| Study design | Observational study |
|---|---|
| Primary study design | Observational |
| Secondary study design | Cross sectional study |
| Study setting(s) | Other |
| Study type | Other |
| Participant information sheet | Not available in web format, please use the contact details to request a patient information sheet |
| Scientific title | Kinetics of left ventricular function and regional mechanics at the onset of exercise in sedentary and endurance-trained subjects |
| Study objectives | The trialists hypothesized that the fast increase of stroke volume at the onset of exercise would result mainly from a rapid improvement in diastolic function implying an important contribution of LV untwist. They hypothesized that these mechanisms adapted better in endurance-trained subjects. |
| Ethics approval(s) | University of Avignon ethics committee |
| Health condition(s) or problem(s) studied | Cardiac evaluations at rest and during effort in healthy young controls and endurance-trained cyclists |
| Intervention | This study was a pilot study to check the feasibility of fast evaluation of echocardiography every 15 seconds during exercise. Young male cyclists (18 – 25 years) and age-matched sedentary controls performed five similar constant work-load exercises on a cyclo-ergometer (target heart rate: 130 bpm), in order to follow kinetics of diastolic and systolic myocardial strains by speckle-tracking echocardiography with high temporal resolution. Cardiac function was assessed every 15 seconds during the first minute and then every 30 seconds up until 240 seconds. |
| Intervention type | Other |
| Primary outcome measure | Left ventricular strains and twist/untwist kinetics during the transitions from rest to exercise, measured non-invasively using 2D-strain echocardiography. Each subject of the study was evaluated one time only (i.e. transversal design) |
| Secondary outcome measures | Global systolic and diastolic functions, measured non-invasively using Doppler echocardiography. Each subject of the study was evaluated one time only (i.e. transversal design) |
| Overall study start date | 01/01/2015 |
| Completion date | 20/12/2017 |
Eligibility
| Participant type(s) | Healthy volunteer |
|---|---|
| Age group | Adult |
| Lower age limit | 18 Years |
| Upper age limit | 35 Years |
| Sex | Male |
| Target number of participants | 25 subjects in each group |
| Key inclusion criteria | 1. Cyclists training at least 10 hours per week for at least 8 years or sedentary young men reporting regular training habits 2. 18-35 years old 3. Non-smokers 4. No history of diabetes, hypertension or cardiovascular disease 5. Normal clinical examination 6. In sinus rhythm 7. Screening echocardiography showing normal left and right heart morphology and function and the absence of valvular disease |
| Key exclusion criteria | 1. Smokers 2. History of diabetes, hypertension or cardiovascular disease 3. Abnormal sinus rhythm 4. Screening echocardiography shows abnormal left and right heart morphology and function and or valvular disease |
| Date of first enrolment | 01/09/2015 |
| Date of final enrolment | 20/12/2016 |
Locations
Countries of recruitment
- France
Study participating centre
France
Sponsor information
University/education
74 rue Louis Pasteur
Avignon
84000
France
| Phone | +33 (0)490162931 |
|---|---|
| stephane.nottin@univ-avignon.fr | |
| Website | http://www.univ-avignon.fr |
"ROR" |
https://ror.org/00mfpxb84 |
Funders
Funder type
University/education
No information available
Results and Publications
| Intention to publish date | 01/02/2018 |
|---|---|
| Individual participant data (IPD) Intention to share | No |
| IPD sharing plan summary | Data sharing statement to be made available at a later date |
| Publication and dissemination plan | The trialists plan two publications in high-impact peer reviewed journals. The first one will be sent soon to the Journal of Physiology (London) and the second will be sent to Medicine & Science in Sports & Exercise. |
| IPD sharing plan | The data sharing plans for the current study are unknown and will be made available at a later date. |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Results article | 01/11/2021 | 13/01/2022 | Yes | No |
Editorial Notes
13/01/2022: Publication reference added.
