An evaluation of systemic metronidazole and amoxycillin as an adjunct to routine therapy in the treatment of severe periodontal disease

ISRCTN ISRCTN18247441
DOI https://doi.org/10.1186/ISRCTN18247441
Secondary identifying numbers R/ROONEY/291
Submission date
23/01/2004
Registration date
23/01/2004
Last edited
06/01/2010
Recruitment status
No longer recruiting
Overall study status
Completed
Condition category
Oral Health
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data

Plain English summary of protocol

Not provided at time of registration

Contact information

Mrs Jane Rooney
Scientific

University of Bristol
Dental Hospital and School
Lower Maudlin Street
Bristol
BS1 2LY
United Kingdom

Phone +44 (0)117 9294472
Email J.C.Rooney@bristol.ac.uk

Study information

Study designRandomised controlled trial
Primary study designInterventional
Secondary study designRandomised controlled trial
Study setting(s)Not specified
Study typeNot Specified
Scientific title
Study objectivesThe aim of this study is to evaluate systematic metronidazole and amoxycillin, alone and combined, as adjuncts to root planning in the treatment of patients with severe adult periodontis. In addition, microbiological monitoring will be performed in order to determine of pre-treatment microbiological status influences treatment outcome.
Ethics approval(s)Not provided at time of registration
Health condition(s) or problem(s) studiedOral health/stomatognathic diseases: Severe periodontal disease
InterventionNot provided at time of registration
Intervention typeDrug
Pharmaceutical study type(s)
PhaseNot Specified
Drug / device / biological / vaccine name(s)metronidazole and amoxycillin
Primary outcome measureNot provided at time of registration
Secondary outcome measuresNot provided at time of registration
Overall study start date01/06/1994
Completion date01/06/1997

Eligibility

Participant type(s)Patient
Age groupAdult
SexNot Specified
Target number of participantsAdded 06/01/10: 66
Key inclusion criteriaNot provided at time of registration
Key exclusion criteriaNot provided at time of registration
Date of first enrolment01/06/1994
Date of final enrolment01/06/1997

Locations

Countries of recruitment

  • England
  • United Kingdom

Study participating centre

University of Bristol
Bristol
BS1 2LY
United Kingdom

Sponsor information

NHS R&D Regional Programme Register - Department of Health (UK)
Government

The Department of Health
Richmond House
79 Whitehall
London
SW1A 2NL
United Kingdom

Phone +44 (0)20 7307 2622
Email dhmail@doh.gsi.org.uk
Website http://www.doh.gov.uk

Funders

Funder type

Government

NHS Executive South West (UK)

No information available

Results and Publications

Intention to publish date
Individual participant data (IPD) Intention to shareNo
IPD sharing plan summaryNot provided at time of registration
Publication and dissemination planNot provided at time of registration
IPD sharing plan

Study outputs

Output type Details Date created Date added Peer reviewed? Patient-facing?
Results article results 01/04/2002 Yes No