Contact information
Type
Scientific
Primary contact
Mrs Jane Rooney
ORCID ID
Contact details
University of Bristol
Dental Hospital and School
Lower Maudlin Street
Bristol
BS1 2LY
United Kingdom
+44 (0)117 9294472
J.C.Rooney@bristol.ac.uk
Additional identifiers
EudraCT number
ClinicalTrials.gov number
Protocol/serial number
R/ROONEY/291
Study information
Scientific title
Acronym
Study hypothesis
The aim of this study is to evaluate systematic metronidazole and amoxycillin, alone and combined, as adjuncts to root planning in the treatment of patients with severe adult periodontis. In addition, microbiological monitoring will be performed in order to determine of pre-treatment microbiological status influences treatment outcome.
Ethics approval
Not provided at time of registration
Study design
Randomised controlled trial
Primary study design
Interventional
Secondary study design
Randomised controlled trial
Trial setting
Not specified
Trial type
Not Specified
Patient information sheet
Condition
Oral health/stomatognathic diseases: Severe periodontal disease
Intervention
Not provided at time of registration
Intervention type
Drug
Phase
Not Specified
Drug names
metronidazole and amoxycillin
Primary outcome measures
Not provided at time of registration
Secondary outcome measures
Not provided at time of registration
Overall trial start date
01/06/1994
Overall trial end date
01/06/1997
Reason abandoned
Eligibility
Participant inclusion criteria
Not provided at time of registration
Participant type
Patient
Age group
Adult
Gender
Not Specified
Target number of participants
Added 06/01/10: 66
Participant exclusion criteria
Not provided at time of registration
Recruitment start date
01/06/1994
Recruitment end date
01/06/1997
Locations
Countries of recruitment
United Kingdom
Trial participating centre
University of Bristol
Bristol
BS1 2LY
United Kingdom
Sponsor information
Organisation
NHS R&D Regional Programme Register - Department of Health (UK)
Sponsor details
The Department of Health
Richmond House
79 Whitehall
London
SW1A 2NL
United Kingdom
+44 (0)20 7307 2622
dhmail@doh.gsi.org.uk
Sponsor type
Government
Website
Funders
Funder type
Government
Funder name
NHS Executive South West (UK)
Alternative name(s)
Funding Body Type
Funding Body Subtype
Location
Results and Publications
Publication and dissemination plan
Not provided at time of registration
Intention to publish date
Participant level data
Not provided at time of registration
Results - basic reporting
Publication summary
2002 results in http://www.ncbi.nlm.nih.gov/pubmed/11966932
Publication citations
-
Results
Rooney J, Wade WG, Sprague SV, Newcombe RG, Addy M, Adjunctive effects to non-surgical periodontal therapy of systemic metronidazole and amoxycillin alone and combined. A placebo controlled study., J. Clin. Periodontol., 2002, 29, 4, 342-350.