Condition category
Circulatory System
Date applied
30/09/2004
Date assigned
30/09/2004
Last edited
20/04/2015
Prospective/Retrospective
Retrospectively registered
Overall trial status
Completed
Recruitment status
No longer recruiting

Plain English Summary

Not provided at time of registration

Trial website

Contact information

Type

Scientific

Primary contact

Dr Harpal Randeva

ORCID ID

Contact details

Metabolic Unit
Coventry & Warwickshire Hospital
Stoney Stanton Road
Coventry
CV1 4FH
United Kingdom
+44 (0)2476 844091/572552
harpal.randeva@uhcw.nhs.uk

Additional identifiers

EudraCT number

ClinicalTrials.gov number

Protocol/serial number

N0295132800

Study information

Scientific title

A pilot study to determine the effects of corticotrophin releasing hormone (CRH) on myocardial function

Acronym

Study hypothesis

What is the effect of a single intravenous dose of CRH on myocardial contractility in normal, healthy subjects?

Ethics approval

Not provided at time of registration

Study design

Double-blind randomised crossover pilot study

Primary study design

Interventional

Secondary study design

Randomised cross over trial

Trial setting

Hospitals

Trial type

Treatment

Patient information sheet

Not available in web format, please use the contact details below to request a patient information sheet

Condition

Cardiovascular: Myocardial function

Intervention

Single intravenous dose of CRH

Intervention type

Drug

Phase

Not Applicable

Drug names

Corticotrophin releasing hormone

Primary outcome measures

Changes in measure of cardiac contractility/function as assessed by echocardiography: ejection fraction, fractional shortening, stroke volume, diastolic left ventricular filling, myocardial velocity, strain rate and strain.

Secondary outcome measures

Not provided at time of registration

Overall trial start date

08/12/2003

Overall trial end date

30/04/2004

Reason abandoned

Eligibility

Participant inclusion criteria

Healthy men or women, 18-60 years of age.

Participant type

Patient

Age group

Adult

Gender

Both

Target number of participants

10 in total

Participant exclusion criteria

Not provided at time of registration

Recruitment start date

08/12/2003

Recruitment end date

30/04/2004

Locations

Countries of recruitment

United Kingdom

Trial participating centre

Coventry & Warwickshire Hospital
Coventry
CV1 4FH
United Kingdom

Sponsor information

Organisation

Department of Health

Sponsor details

Richmond House
79 Whitehall
London
SW1A 2NL
United Kingdom

Sponsor type

Government

Website

http://www.dh.gov.uk/Home/fs/en

Funders

Funder type

Government

Funder name

University Hospitals Coventry and Warwickshire NHS Trust (UK)

Alternative name(s)

Funding Body Type

Funding Body Subtype

Location

Results and Publications

Publication and dissemination plan

Not provided at time of registration

Intention to publish date

Participant level data

Not provided at time of registration

Results - basic reporting

Publication summary

Publication citations

Additional files

Editorial Notes