Six-week high-intensity exercise program for middle-aged patients with knee osteoarthritis: a randomized controlled trial

ISRCTN ISRCTN20244858
DOI https://doi.org/10.1186/ISRCTN20244858
Secondary identifying numbers N/A
Submission date
15/08/2005
Registration date
16/08/2005
Last edited
20/12/2007
Recruitment status
No longer recruiting
Overall study status
Completed
Condition category
Musculoskeletal Diseases
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data

Plain English summary of protocol

Not provided at time of registration

Contact information

Dr Ingemar Petersson
Scientific

Spenshult Hospital for Rheumatic Diseases
Oskarström
S-313 92
Sweden

Email ingemar.petersson@spenshult.se

Study information

Study designRandomised controlled trial
Primary study designInterventional
Secondary study designRandomised controlled trial
Study setting(s)Hospital
Study typeTreatment
Scientific title
Study objectivesShort-term high-intensity exercise improves self-reported pain, function and quality of life in middle-aged patients with moderate to severe knee osteoarthritis.
Ethics approval(s)The study was approved by the Research Ethics Committee at Lund University (Sweden) (ref: LU 99-98), and is in compliance with the Helsinki Declaration.
Health condition(s) or problem(s) studiedKnee osteoarthritis
InterventionA six-week high-intensity supervised exercise session twice a week, or a non-intervention control group.
Intervention typeOther
Primary outcome measureKnee injury and Osteoarthritis Outcome Score (KOOS, a disease specific questionnaire, assessing pain, other symptoms, activities of daily living, sport and recreation function and knee-related quality of life). Time points of interest were 6 weeks and 6 months.
Secondary outcome measures1. 36-item short form health survey (SF-36, a generic measure of general health status)
2. Five tests of functional performance:
2.1. Åstrands bicycle-ergometre test
2.2. Rising on one leg from sitting on lowest possible height
2.3. One-leg hop
2.4. Lateral step-up
2.5. One-leg semi squatting
2.6. Heel-rising on one leg
Overall study start date09/10/1998
Completion date08/10/2001

Eligibility

Participant type(s)Patient
Age groupAdult
SexBoth
Target number of participants61
Key inclusion criteria1. Aged 35 - 65 years
2. Living in a defined geographic area
3. Diagnosis of radiographic knee osteoarthritis according to Kellgren & Lawrence grade III or more (i.e joint space narrowing and definite osteophytes)
Key exclusion criteria1. Inflammatory joint disease
2. Anterior cruciate ligament injury
3. Known symptomatic injury to the menisci
4. Hip symptoms more aggravating than the knee symptoms
5. About to have knee replacement surgery within 6 months
6. Co-morbidities not allowing exercise
Date of first enrolment09/10/1998
Date of final enrolment08/10/2001

Locations

Countries of recruitment

  • Sweden

Study participating centre

Spenshult Hospital for Rheumatic Diseases
Oskarström
S-313 92
Sweden

Sponsor information

The Swedish Rheumatism Association (Sweden)
Charity

Alströmergatan 39
Box 12851
Stockholm
S-112 98
Sweden

Email jan.bagge@reumatikerforbundet.se
Website http://www.reumatikerforbundet.org
ROR logo "ROR" https://ror.org/00zps9v98

Funders

Funder type

Research organisation

The Vårdal Foundation (Sweden)

No information available

The Swedish Rheumatism Association in Stockholm (Sweden)

No information available

The Swedish Rheumatism Association in Gothenburgh (Sweden)

No information available

The Swedish Research Council (Sweden)

No information available

The Department of Research and Development at Spenshult Hospital for Rheumatic Diseases (Sweden)

No information available

Results and Publications

Intention to publish date
Individual participant data (IPD) Intention to shareNo
IPD sharing plan summaryNot provided at time of registration
Publication and dissemination planNot provided at time of registration
IPD sharing plan

Study outputs

Output type Details Date created Date added Peer reviewed? Patient-facing?
Results article Results 30/05/2005 Yes No