Condition category
Infections and Infestations
Date applied
29/09/2006
Date assigned
29/09/2006
Last edited
10/09/2012
Prospective/Retrospective
Retrospectively registered
Overall trial status
Completed
Recruitment status
No longer recruiting

Plain English Summary

Not provided at time of registration

Trial website

Contact information

Type

Scientific

Primary contact

Dr Barbara Philips

ORCID ID

Contact details

Anaesthetics Department
Jenner Wing
St George's Hospital
Blackshaw Road
Tooting
London
SW17 0QT
United Kingdom
+44 (0)20 8725 5071
bphilips@sghms.ac.uk

Additional identifiers

EudraCT number

ClinicalTrials.gov number

Protocol/serial number

N0236173812

Study information

Scientific title

Acronym

Study hypothesis

1. To investigate the association between strict glycaemic control and the subsequent development of nosocomial infection.
2. To determine the relationship between nosocomial pneumonia and the presence of glucose in endotracheal secretion.

Ethics approval

Not provided at time of registration

Study design

Randomised controlled trial

Primary study design

Interventional

Secondary study design

Randomised controlled trial

Trial setting

Not specified

Trial type

Not Specified

Patient information sheet

Condition

Infections and Infestations: Nosocomial infections

Intervention

All ventilated patients will be randomised to 2 groups:
Group 1 - the treatment group: a continuous infusion of insulin will be started once blood glucose levels exceed 6.1 mmol/l and adjusted accordingly to maintain blood sugar levels between 4.4 and 6.1 mmol/l
Group 2 - the control group: insulin will be adjusted to maintain blood glucose levels <= 10 mmol/l

Intervention type

Other

Phase

Not Specified

Drug names

Primary outcome measures

Nosocomial infection.

Secondary outcome measures

Not provided at time of registration

Overall trial start date

01/11/2002

Overall trial end date

01/05/2005

Reason abandoned

Eligibility

Participant inclusion criteria

Not provided at time of registration

Participant type

Patient

Age group

Not Specified

Gender

Not Specified

Target number of participants

100 subjects and 100 controls, total 200

Participant exclusion criteria

Not provided at time of registration

Recruitment start date

01/11/2002

Recruitment end date

01/05/2005

Locations

Countries of recruitment

United Kingdom

Trial participating centre

Anaesthetics Department
London
SW17 0QT
United Kingdom

Sponsor information

Organisation

Record Provided by the NHSTCT Register - 2006 Update - Department of Health

Sponsor details

The Department of Health
Richmond House
79 Whitehall
London
SW1A 2NL
United Kingdom
+44 (0)20 7307 2622
dhmail@doh.gsi.org.uk

Sponsor type

Government

Website

http://www.dh.gov.uk/Home/fs/en

Funders

Funder type

Government

Funder name

St George's Healthcare NHS Trust (UK), NHS R&D Support Funding

Alternative name(s)

Funding Body Type

Funding Body Subtype

Location

Results and Publications

Publication and dissemination plan

Not provided at time of registration

Intention to publish date

Participant level data

Not provided at time of registration

Results - basic reporting

Publication summary

1. 2005 results on nosocomial pneumonia and the presence of glucose in endotracheal secretion in http://www.ncbi.nlm.nih.gov/pubmed/16135681

Publication citations

  1. Results on nosocomial pneumonia and the presence of glucose in endotracheal secretion

    Philips BJ, Redman J, Brennan A, Wood D, Holliman R, Baines D, Baker EH, Glucose in bronchial aspirates increases the risk of respiratory MRSA in intubated patients., Thorax, 2005, 60, 9, 761-764, doi: 10.1136/thx.2004.035766.

Additional files

Editorial Notes