UKCCCR trial to study the effect on breast cancer mortality of annual mammographic screening starting at age 40
| ISRCTN | ISRCTN24647151 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN24647151 |
| Secondary identifying numbers | G9000793 |
- Submission date
- 06/04/2000
- Registration date
- 06/04/2000
- Last edited
- 19/08/2020
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Cancer
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Plain English Summary
Not provided at time of registration
Contact information
Dr Sue Moss
Scientific
Scientific
Professor of Cancer Epidemiology
Centre for Cancer Prevention
Queen Mary University of London
Wolfson Institute of Preventive Medicine Charterhouse Square London
London
EC1M 6BQ
United Kingdom
| Phone | +44 (0)207 882 5841 |
|---|---|
| s.moss@qmul.ac.uk |
Study information
| Study design | Randomised controlled trial |
|---|---|
| Primary study design | Interventional |
| Secondary study design | Randomised controlled trial |
| Study setting(s) | Hospital |
| Study type | Screening |
| Participant information sheet | Not available in web format, please use the contact details below to request a patient information sheet |
| Scientific title | UKCCCR trial to study the effect on breast cancer mortality of annual mammographic screening starting at age 40 |
| Study acronym | The 'Age' trial |
| Study hypothesis | To determine the effectiveness of mammographic screening starting at age 40, compared with starting at age 50, in reducing mortality from breast cancer. |
| Ethics approval(s) | Ethics approval from Central London REC 98/2/40. |
| Condition | Breast cancer |
| Intervention | Women in the intervention group are offered annual screening by mammography until the year of their 48th birthday. Screening is by 2-view mammography at 1st screen and single view subsequently. All women in both intervention and control groups will be invited for screening in the NHSBSP between the age of 50-52. |
| Intervention type | Other |
| Primary outcome measure | Deaths from breast cancer in women free of the disease at trial entry in the two groups. Information on prognostic factors of all breast cancers is also collected. |
| Secondary outcome measures | Not provided at time of registration |
| Overall study start date | 30/07/1990 |
| Overall study end date | 31/12/2010 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Adult |
| Sex | Female |
| Target number of participants | 195,000. Recruitment ceased at 160,000 |
| Participant inclusion criteria | Women aged 40-41 identified from Health Authorities registers |
| Participant exclusion criteria | Women under care for breast cancer may be removed from the prior notification list by the GPs prior to randomisation |
| Recruitment start date | 30/07/1990 |
| Recruitment end date | 31/12/2010 |
Locations
Countries of recruitment
- England
- United Kingdom
Study participating centre
Queen Mary University of London
London
EC1M 6BQ
United Kingdom
EC1M 6BQ
United Kingdom
Sponsor information
Medical Research Council (MRC) (UK)
Research council
Research council
20 Park Crescent
London
W1B 1AL
United Kingdom
| Phone | +44 (0)20 7636 5422 |
|---|---|
| clinical.trial@headoffice.mrc.ac.uk | |
| Website | http://www.mrc.ac.uk |
Funders
Funder type
Research council
Medical Research Council (MRC) (UK)
Government organisation / National government
Government organisation / National government
- Alternative name(s)
- Medical Research Council (United Kingdom), UK Medical Research Council, MRC
- Location
- United Kingdom
Long-term follow up funded by National Institute for Health Research (NIHR) / Health Technology Assessment (HTA)
No information available
Results and Publications
| Intention to publish date | |
|---|---|
| Individual participant data (IPD) Intention to share | No |
| IPD sharing plan summary | Not provided at time of registration |
| Publication and dissemination plan | Not provided at time of registration |
| IPD sharing plan |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Protocol article | protocol | 01/07/1999 | Yes | No | |
| Other publications | Implications of pathologist concordance | 01/03/2002 | Yes | No | |
| Results article | results | 09/12/2006 | Yes | No | |
| Other publications | assessment of contamination in the control group: | 01/04/2010 | Yes | No | |
| Results article | results | 01/09/2015 | Yes | No | |
| Results article | results | 01/04/2016 | Yes | No | |
| Results article | results | 01/09/2020 | 19/08/2020 | Yes | No |
Editorial Notes
19/08/2020: Publication reference added.
08/02/2016: Publication reference added.
