Are the psychoto-mimetic effects of cannabis mediated via dopamine?
| ISRCTN | ISRCTN27139591 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN27139591 |
| Secondary identifying numbers | N0263181140 |
- Submission date
- 28/09/2007
- Registration date
- 28/09/2007
- Last edited
- 14/10/2014
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Mental and Behavioural Disorders
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Record updated in last year
Plain English summary of protocol
Not provided at time of registration
Contact information
Prof - -
Scientific
Scientific
Institute of Nuclear Medicine
University College Hospital
5th Floor
235 Euston Road
London
NW1 2BU
United Kingdom
Study information
| Study design | Randomised controlled trial |
|---|---|
| Primary study design | Interventional |
| Secondary study design | Randomised controlled trial |
| Study setting(s) | Hospital |
| Study type | Treatment |
| Scientific title | |
| Study objectives | Are the transient psychotic like effects induced by delta-9-tetrahydrocannibinol correlated with excess dopamine release in the striatum as measures by (123I)-IBZM single photon emission tomography (SPET)? |
| Ethics approval(s) | Not provided at time of registration |
| Health condition(s) or problem(s) studied | Mental and Behavioural Disorders: Psychosis |
| Intervention | 1. THC drug 2. Placebo |
| Intervention type | Drug |
| Pharmaceutical study type(s) | |
| Phase | Not Applicable |
| Drug / device / biological / vaccine name(s) | Cannabis |
| Primary outcome measure | 1. The percentage decrease in specific (123I)-IBZM binding under THC vs placebo conditions 2. The relationship between THC induced PANSS increases and (123I)-IBZM displacement |
| Secondary outcome measures | Not provided at time of registration |
| Overall study start date | 01/06/2006 |
| Completion date | 01/12/2007 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Not Specified |
| Sex | Not Specified |
| Target number of participants | Not provided at time of registration |
| Key inclusion criteria | External patients |
| Key exclusion criteria | Not provided at time of registration |
| Date of first enrolment | 01/06/2006 |
| Date of final enrolment | 01/12/2007 |
Locations
Countries of recruitment
- England
- United Kingdom
Study participating centre
Institute of Nuclear Medicine
London
NW1 2BU
United Kingdom
NW1 2BU
United Kingdom
Sponsor information
Record Provided by the NHSTCT Register - 2007 Update - Department of Health
Government
Government
The Department of Health, Richmond House, 79 Whitehall
London
SW1A 2NL
United Kingdom
| Phone | +44 (0)20 7307 2622 |
|---|---|
| dhmail@doh.gsi.org.uk | |
| Website | http://www.dh.gov.uk/Home/fs/en |
Funders
Funder type
Government
University College London Hospitals NHS Foundation Trust (UK)
No information available
NHS R&D Support Funding (UK)
No information available
Results and Publications
| Intention to publish date | |
|---|---|
| Individual participant data (IPD) Intention to share | No |
| IPD sharing plan summary | Not provided at time of registration |
| Publication and dissemination plan | Not provided at time of registration |
| IPD sharing plan |
