Condition category
Circulatory System
Date applied
31/01/2002
Date assigned
31/01/2002
Last edited
10/09/2007
Prospective/Retrospective
Retrospectively registered
Overall trial status
Completed
Recruitment status
No longer recruiting

Plain English Summary

Not provided at time of registration

Trial website

Contact information

Type

Scientific

Primary contact

Dr N Sattar

ORCID ID

Contact details

University Department of Pathological Biochemistry
Glasgow Royal Infirmary
Glasgow
G31 2ER
United Kingdom
+44 (0)141 211 4312
nsattar@clinmed.gla.ac.uk

Additional identifiers

EudraCT number

ClinicalTrials.gov number

Protocol/serial number

PG/99124

Study information

Scientific title

Acronym

Study hypothesis

Not provided at time of registration

Ethics approval

Not provided at time of registration

Study design

Randomised controlled trial

Primary study design

Interventional

Secondary study design

Randomised controlled trial

Trial setting

Hospitals

Trial type

Treatment

Patient information sheet

Condition

Cardiac syndrome X

Intervention

1. Metformin 500 mg twice daily (BD)
2. Matching placebo 1 tab BD

Both treatments will continue for 8 weeks.

Intervention type

Drug

Phase

Not Specified

Drug names

Metformin

Primary outcome measures

Not provided at time of registration

Secondary outcome measures

Not provided at time of registration

Overall trial start date

01/01/1997

Overall trial end date

01/01/2001

Reason abandoned

Eligibility

Participant inclusion criteria

Women, post menopausal but less than 70 years with Cardiac Syndrome X (definition angina/positive exercise test/normal coronary arteriogram)

Participant type

Patient

Age group

Adult

Gender

Female

Target number of participants

Not provided at time of registration

Participant exclusion criteria

Not provided at time of registration

Recruitment start date

01/01/1997

Recruitment end date

01/01/2001

Locations

Countries of recruitment

United Kingdom

Trial participating centre

University Department of Pathological Biochemistry
Glasgow
G31 2ER
United Kingdom

Sponsor information

Organisation

British Heart Foundation

Sponsor details

14 Fitzhardinge Street
London
W1H 6DH
United Kingdom
+44 (0)20 7935 0185
research@bhf.org.uk

Sponsor type

Charity

Website

Funders

Funder type

Charity

Funder name

British Heart Foundation (UK)

Alternative name(s)

BHF

Funding Body Type

private sector organisation

Funding Body Subtype

foundation

Location

United Kingdom

Results and Publications

Publication and dissemination plan

Not provided at time of registration

Intention to publish date

Participant level data

Not provided at time of registration

Results - basic reporting

Publication summary

Results in: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16949486

Publication citations

  1. Results

    Jadhav S, Ferrell W, Greer IA, Petrie JR, Cobbe SM, Sattar N, Effects of metformin on microvascular function and exercise tolerance in women with angina and normal coronary arteries: a randomized, double-blind, placebo-controlled study., J. Am. Coll. Cardiol., 2006, 48, 5, 956-963, doi: 10.1016/j.jacc.2006.04.088.

Additional files

Editorial Notes