Condition category
Injury, Occupational Diseases, Poisoning
Date applied
Date assigned
Last edited
Retrospectively registered
Overall trial status
Recruitment status
No longer recruiting

Plain English Summary

Background and study aims
Despite major improvements in emergency care, severe trauma, mainly due to road traffic crashes, falls, and assaults remains the leading cause of death in the industrialized countries. The rapid transfer of trauma victims to a specialized trauma centre is life-saving. On admission, the goal of diagnostic work-up is to identify life-threatening injuries, immediately followed by surgical and intensive care. The current diagnostic standard includes different imaging procedures like ultrasound, x-rays, and a cranial (head) computed tomography (CT) scan supplemented by CT scans of individual body regions as needed. In many trauma centres worldwide, this often time-consuming approach has now been replaced by a whole-body CT-scan, called the "pan-scan" for trauma. In theory, the pan-scan may detect injuries earlier and more precisely than the traditional stepwise procedure. Although compelling and plausible, there is a lack of evidence of whether the pan-scan benefits patients in terms of improved survival. The potential advantages of the pan-scan must also be traded-off against the increased exposure to radiation. The aim of this study is to find out whether the introduction of pan-scan into trauma resuscitation decreases mortality (death rate) for patients after severe blunt trauma compared to a conventional, staged work-up.

Who can participate?
Patients with suspected blunt multiple trauma requiring resuscitation in the emergency department/trauma bay

What does the study involve?
The outcomes of patients admitted before and after the introduction of pan-scan for severe trauma are compared. Mortality (death rate), adjusted for injury severity and other factors, morbidity (i.e. inflammatory complications like lung failure and multiple organ failure), and emergency department time are assessed.

What are the possible benefits and risks of participating?
Not provided at time of registration

Where is the study run from?
The University Trauma Centres in Murnau and Greifswald (Germany)

When is the study starting and how long is it expected to run for?
July to October 2011

Who is funding the study?
Investigator initiated and funded (Germany)

Who is the main contact?
Dr Dirk Stengel

Trial website

Contact information



Primary contact

Dr Dirk Stengel


Contact details

Emergency Hospital Berlin (Unfallkrankenhaus Berlin)
Warener Str. 7
+49 (0)30 5681 4090

Additional identifiers

EudraCT number number

Protocol/serial number


Study information

Scientific title

Effectiveness of primary whole-body computed tomography (pan-scan) in improving process and outcome quality after severe and multiple trauma (The Pan-scan for Trauma Resuscitation Study, Part 3)



Study hypothesis

The introduction of a single-pass whole-body, contrast-enhanced computed tomography (Pan-Scan) into trauma resuscitation decreases all-cause in hospital mortality of patients after severe blunt trauma compared to a conventional, staged work-up algorithm

Ethics approval

Bavarian Chamber of Physicians (Bayerische Landesärztekammer), 16/03/2010

Study design

Retrospective cohort study

Primary study design


Secondary study design

Cohort study

Trial setting


Trial type


Patient information sheet

Not available in web format, please use the contact details to request a patient information sheet


Multiple and severe blunt trauma


1. Control cohort: Trauma resuscitation and staged diagnostic work-up according to Advanced Trauma Life Support (ATLS(R)) standards including physical examination (ABCDE-algorithm), focused assessment with sonography for trauma (FAST, including thoracic views), plain x-rays of the chest, pelvis, and spine, cranial CT, followed by selective CT-scans of suspicious body regions
2. Intervention cohort: Trauma resuscitation and staged diagnostic work-up according to Advanced Trauma Life Support (ATLS(R)) standards, primary single-pass pan-scan

Intervention type



Not Applicable

Drug names

Primary outcome measure

All-cause in-hospital mortality

Secondary outcome measures

1. All-cause in-hospital mortality, adjusted for injury severity and other confounding / interaction variables identified by multivariable logistic regression analysis
2. Morbidity (i.e. inflammatory complications like lung failure [ARDS] multiple organ failure [MOF])
3. Emergency department time

Overall trial start date


Overall trial end date


Reason abandoned (if study stopped)


Participant inclusion criteria

Consecutive men and women (no age restrictions) with suspected blunt multiple trauma directly transferred from the scene to the hospital and requiring resuscitation in the emergency department / trauma bay

Participant type


Age group




Target number of participants

300 per group

Participant exclusion criteria

Due to the retrospective nature of this analysis only patients with insufficient or lacking information in the hospital documentation system will be excluded from the analysis

Recruitment start date


Recruitment end date



Countries of recruitment


Trial participating centre

Emergency Hospital Berlin (Unfallkrankenhaus Berlin)

Sponsor information


Emergency Hospital Berlin (Unfallkrankenhaus Berlin) (Germany)

Sponsor details

Warener Str. 7
+49 (0)30 5681 4090

Sponsor type

Hospital/treatment centre



Funder type

Hospital/treatment centre

Funder name

Investigator initiated and funded (Germany)

Alternative name(s)

Funding Body Type

Funding Body Subtype


Results and Publications

Publication and dissemination plan

Not provided at time of registration

Intention to publish date

Participant level data

Not provided at time of registration

Basic results (scientific)

Publication list

2011 results in:

Publication citations

  1. Results

    Hutter M, Woltmann A, Hierholzer C, Gärtner C, Bühren V, Stengel D, Association between a single-pass whole-body computed tomography policy and survival after blunt major trauma: a retrospective cohort study., Scand J Trauma Resusc Emerg Med, 2011, 19, 73, doi: 10.1186/1757-7241-19-73.

Additional files

Editorial Notes

19/04/2017: Plain English summary added.