Role of epidermal apoptosis in the clearance of psoriatic plaques
| ISRCTN | ISRCTN38471512 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN38471512 |
| Secondary identifying numbers | 6639 |
- Submission date
- 12/05/2010
- Registration date
- 12/05/2010
- Last edited
- 28/03/2018
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Skin and Connective Tissue Diseases
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Record updated in last year
Plain English summary of protocol
Not provided at time of registration
Contact information
Dr Sophie Weatherhead
Scientific
Scientific
Newcastle University
Dermatology
2nd Floor William Leech Building
Medical School
Newcastle
NE2 4HH
United Kingdom
Study information
| Study design | Single centre non-randomised trial |
|---|---|
| Primary study design | Observational |
| Secondary study design | Single-centre |
| Study setting(s) | Other |
| Study type | Treatment |
| Participant information sheet | Not available in web format, please use contact details to request a participant information sheet |
| Scientific title | Role of epidermal apoptosis in the clearance of psoriatic plaques: a single centre non-randomised trial |
| Study acronym | MECH-PSOR-CLEAR |
| Study objectives | To investigate whether anti-psoriatic treatments induce epidermal apoptosis, and whether this may account for plaque clearance. |
| Ethics approval(s) | MREC approved (ref: 2002/255) |
| Health condition(s) or problem(s) studied | Topic: Skin; Subtopic: Skin (all Subtopics); Disease: Dermatology |
| Intervention | Biopsies (skin). |
| Intervention type | Other |
| Primary outcome measure | Apoptotic epidermal cells |
| Secondary outcome measures | Effect of gender, age and treatment |
| Overall study start date | 01/09/2002 |
| Completion date | 30/04/2013 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Not Specified |
| Sex | Not Specified |
| Target number of participants | Planned sample size: 100 |
| Key inclusion criteria | Not provided at time of registration |
| Key exclusion criteria | Not provided at time of registration |
| Date of first enrolment | 01/09/2002 |
| Date of final enrolment | 30/04/2013 |
Locations
Countries of recruitment
- England
- United Kingdom
Study participating centre
Newcastle University
Newcastle
NE2 4HH
United Kingdom
NE2 4HH
United Kingdom
Sponsor information
Newcastle upon Tyne Hospitals NHS Foundation Trust
Hospital/treatment centre
Hospital/treatment centre
Royal Victoria Infirmary
Queen Victoria Road
Newcastle Upon Tyne
NE1 4LP
England
United Kingdom
| Website | http://www.newcastle-hospitals.org.uk/services/index.aspx |
|---|---|
"ROR" |
https://ror.org/05p40t847 |
Funders
Funder type
Charity
Psoriasis Association (UK)
No information available
Results and Publications
| Intention to publish date | |
|---|---|
| Individual participant data (IPD) Intention to share | No |
| IPD sharing plan summary | Not provided at time of registration |
| Publication and dissemination plan | Not provided at time of registration |
| IPD sharing plan |
Editorial Notes
28/03/2018: No publications found, verifying study status with principal investigator.
05/02/2016: No publications found, verifying study status with principal investigator
