Contact information
Type
Scientific
Primary contact
Prof Simon Gowers
ORCID ID
Contact details
Department of Psychiatry
University of Liverpool
Academic Unit
Pine Lodge
79 Liverpool Road
Chester
CH2 1AW
United Kingdom
+44 (0)1244 364660
s.gowers@liv.ac.uk
Additional identifiers
EudraCT number
ClinicalTrials.gov number
Protocol/serial number
HTA 97/42/02
Study information
Scientific title
Acronym
TOUCAN
Study hypothesis
To evaluate, by means of a randomised controlled trial, the cost effectiveness of inpatient against outpatient treatment of adolescent anorexia nervosa and general against specialist treatment, with the following hypotheses:
1. There will be no difference in clinical outcome between inpatient and outpatient treatment in the medium and long term (1 and 2 years) by intention to treat.
2. Specialist outpatient treatment will be more clinically and cost effective than general outpatient treatment.
3. Outpatient treatment will be more cost effective than inpatient treatment.
4. Outpatient treatment will be more acceptable to subject and family in terms of general satisfaction and quality of life.
Please note that, as of 15/01/2008, the anticipated end date of this trial has been updated from 30/06/2004 to 31/12/2008.
Please note that, as of 28/0/2009, the anticipated end date of this trial has been updated from 31/12/2008 to 30/06/2009.
Ethics approval
Does not match inclusion criteria
Study design
Randomised controlled trial
Primary study design
Interventional
Secondary study design
Randomised controlled trial
Trial setting
Hospitals
Trial type
Treatment
Patient information sheet
Condition
Anorexia nervosa
Intervention
1. Routine outpatient treatment by CAMHS
2. Specialist outpatient treatment package (12 sessions) as used in existing Chester service
3. Inpatient treatment.
Intervention type
Other
Phase
Not Specified
Drug names
Primary outcome measures
Composite clinical measure of physical, social and psychological outcome based on Morgan and Russell Scales (MRAOS).
Secondary outcome measures
1. Percentage weight for height
2. Family functioning
3. Health of the Nation Outcome Scales for Children and Adolescents (HoNOSCA)
4. Patient and family acceptablity
Overall trial start date
01/01/2000
Overall trial end date
30/06/2009
Reason abandoned
Eligibility
Participant inclusion criteria
1. All new cases of (Diagnostic and Statistical Manual of Mental Disorders, Fourth edition [DSM IV]) anorexia nervosa
2. Aged 12 - 18 years inclusive
3. Presenting to Child and Adolescent Mental Health Services (CAMHS), Regional Adolescent Services, or Specialist Eating Disorder Services in the North West Region over a two year period
Participant type
Patient
Age group
Child
Gender
Both
Target number of participants
167
Participant exclusion criteria
Not provided at time of registration.
Recruitment start date
01/01/2000
Recruitment end date
30/06/2009
Locations
Countries of recruitment
United Kingdom
Trial participating centre
Department of Psychiatry
Chester
CH2 1AW
United Kingdom
Sponsor information
Organisation
University of Liverpool (UK)
Sponsor details
Research Support Office
The Foresight Building
3 Brownlow Street
Liverpool
L69 3GL
United Kingdom
Sponsor type
University/education
Website
Funders
Funder type
Government
Funder name
NIHR Health Technology Assessment Programme - HTA (UK)
Alternative name(s)
Funding Body Type
Funding Body Subtype
Location
Results and Publications
Publication and dissemination plan
Not provided at time of registration
Intention to publish date
Participant level data
Not provided at time of registration
Results - basic reporting
Publication summary
1. 2007 results in http://www.ncbi.nlm.nih.gov/pubmed/17978323
2. 2010 results in http://www.ncbi.nlm.nih.gov/pubmed/20334748
Publication citations
-
Results
Gowers SG, Clark A, Roberts C, Griffiths A, Edwards V, Bryan C, Smethurst N, Byford S, Barrett B, Clinical effectiveness of treatments for anorexia nervosa in adolescents: randomised controlled trial., Br J Psychiatry, 2007, 191, 427-435, doi: 10.1192/bjp.bp.107.036764.
-
Results
Gowers SG, Clark AF, Roberts C, Byford S, Barrett B, Griffiths A, Edwards V, Bryan C, Smethurst N, Rowlands L, Roots P, A randomised controlled multicentre trial of treatments for adolescent anorexia nervosa including assessment of cost-effectiveness and patient acceptability - the TOuCAN trial., Health Technol Assess, 2010, 14, 15, 1-98, doi: 10.3310/hta14150.