Condition category
Mental and Behavioural Disorders
Date applied
25/04/2003
Date assigned
25/04/2003
Last edited
16/08/2010
Prospective/Retrospective
Retrospectively registered
Overall trial status
Completed
Recruitment status
No longer recruiting

Plain English Summary

Not provided at time of registration

Trial website

Contact information

Type

Scientific

Primary contact

Prof Simon Gowers

ORCID ID

Contact details

Department of Psychiatry
University of Liverpool
Academic Unit
Pine Lodge
79 Liverpool Road
Chester
CH2 1AW
United Kingdom
+44 (0)1244 364660
s.gowers@liv.ac.uk

Additional identifiers

EudraCT number

ClinicalTrials.gov number

Protocol/serial number

HTA 97/42/02

Study information

Scientific title

Acronym

TOUCAN

Study hypothesis

To evaluate, by means of a randomised controlled trial, the cost effectiveness of inpatient against outpatient treatment of adolescent anorexia nervosa and general against specialist treatment, with the following hypotheses:
1. There will be no difference in clinical outcome between inpatient and outpatient treatment in the medium and long term (1 and 2 years) by intention to treat.
2. Specialist outpatient treatment will be more clinically and cost effective than general outpatient treatment.
3. Outpatient treatment will be more cost effective than inpatient treatment.
4. Outpatient treatment will be more acceptable to subject and family in terms of general satisfaction and quality of life.

Please note that, as of 15/01/2008, the anticipated end date of this trial has been updated from 30/06/2004 to 31/12/2008.

Please note that, as of 28/0/2009, the anticipated end date of this trial has been updated from 31/12/2008 to 30/06/2009.

Ethics approval

Does not match inclusion criteria

Study design

Randomised controlled trial

Primary study design

Interventional

Secondary study design

Randomised controlled trial

Trial setting

Hospitals

Trial type

Treatment

Patient information sheet

Condition

Anorexia nervosa

Intervention

1. Routine outpatient treatment by CAMHS
2. Specialist outpatient treatment package (12 sessions) as used in existing Chester service
3. Inpatient treatment.

Intervention type

Other

Phase

Not Specified

Drug names

Primary outcome measures

Composite clinical measure of physical, social and psychological outcome based on Morgan and Russell Scales (MRAOS).

Secondary outcome measures

1. Percentage weight for height
2. Family functioning
3. Health of the Nation Outcome Scales for Children and Adolescents (HoNOSCA)
4. Patient and family acceptablity

Overall trial start date

01/01/2000

Overall trial end date

30/06/2009

Reason abandoned

Eligibility

Participant inclusion criteria

1. All new cases of (Diagnostic and Statistical Manual of Mental Disorders, Fourth edition [DSM IV]) anorexia nervosa
2. Aged 12 - 18 years inclusive
3. Presenting to Child and Adolescent Mental Health Services (CAMHS), Regional Adolescent Services, or Specialist Eating Disorder Services in the North West Region over a two year period

Participant type

Patient

Age group

Child

Gender

Both

Target number of participants

167

Participant exclusion criteria

Not provided at time of registration.

Recruitment start date

01/01/2000

Recruitment end date

30/06/2009

Locations

Countries of recruitment

United Kingdom

Trial participating centre

Department of Psychiatry
Chester
CH2 1AW
United Kingdom

Sponsor information

Organisation

University of Liverpool (UK)

Sponsor details

Research Support Office
The Foresight Building
3 Brownlow Street
Liverpool
L69 3GL
United Kingdom

Sponsor type

University/education

Website

http://www.liv.ac.uk/

Funders

Funder type

Government

Funder name

NIHR Health Technology Assessment Programme - HTA (UK)

Alternative name(s)

Funding Body Type

Funding Body Subtype

Location

Results and Publications

Publication and dissemination plan

Not provided at time of registration

Intention to publish date

Participant level data

Not provided at time of registration

Results - basic reporting

Publication summary

1. 2007 results in http://www.ncbi.nlm.nih.gov/pubmed/17978323
2. 2010 results in http://www.ncbi.nlm.nih.gov/pubmed/20334748

Publication citations

  1. Results

    Gowers SG, Clark A, Roberts C, Griffiths A, Edwards V, Bryan C, Smethurst N, Byford S, Barrett B, Clinical effectiveness of treatments for anorexia nervosa in adolescents: randomised controlled trial., Br J Psychiatry, 2007, 191, 427-435, doi: 10.1192/bjp.bp.107.036764.

  2. Results

    Gowers SG, Clark AF, Roberts C, Byford S, Barrett B, Griffiths A, Edwards V, Bryan C, Smethurst N, Rowlands L, Roots P, A randomised controlled multicentre trial of treatments for adolescent anorexia nervosa including assessment of cost-effectiveness and patient acceptability - the TOuCAN trial., Health Technol Assess, 2010, 14, 15, 1-98, doi: 10.3310/hta14150.

Additional files

Editorial Notes