Condition category
Mental and Behavioural Disorders
Date applied
Date assigned
Last edited
Prospectively registered
Overall trial status
Recruitment status
No longer recruiting
Publication status
Results overdue

Plain English Summary

Background and study aims
We have previously shown that better nutrition reduced offending in a prison and poor nutrition may thus be a cause of antisocial behaviour that we can do something about. This raises the possibility that for a great number of people, not only their health but also their ability to behave sociably could be improved by changing what they eat. This is not an area currently considered in standards of dietary adequacy and little is currently known about the best nutrient dosages required for brain function or behaviour. We will therefore carry out a larger study in 3 Young Offenders Institutes; we will administer vitamin, mineral and essential fatty acid supplements or placebo capsules to confirm our previous results and try to match the prisoners’ blood level changes in these nutrients with a range of behavioural measures.

Who can participate?
Volunteers from three institutions housing 1200 finally sentenced male prisoners aged 16 to 21 years.

What does the study involve?
Volunteers will take capsules containing vitamins, mineral and essential fatty acids or dummy (placebo) capsules. Volunteers will be randomly allocated to receive either the active capsule or placebo, and neither the volunteer nor the person giving them the capsule will know which one they are getting. Blood samples will be collected before and during supplementation to allow us to assess how changes in nutrient levels affect a range of behaviours including: violence, drug-related offences and incidents of self-harm. We will also match changes in blood levels with measures of attention, planning skills, impulse control and social interactions.

What are the possible benefits and risks of participating?
Improving nutrition should improve the health of the prisoners taking the active supplements. Since these are normal nutrients, adverse effects are highly unlikely. Those who dislike having blood taken will be free to decline.

Where is the study run from?
Department of Physiology, Anatomy and Genetics at Oxford University (UK)

When is the study starting and how long is it expected to run for?
The study started in March 2009 and is expected to run for 4 years.

Who is funding the study?
The Wellcome Trust (UK)

Who is the main contact?
Professor John F Stein

Trial website

Contact information



Primary contact

Prof John Stein


Contact details

Anatomy and Genetics
Parks Road
United Kingdom

Additional identifiers

EudraCT number number

Protocol/serial number


Study information

Scientific title

Nutrition as a modifiable causal factor in anti-social behaviours: a randomised, placebo controlled, double blind trial


PINUP (PrIson NUtrition Project)

Study hypothesis

Supplements of vitamins, minerals and essential fatty acids will reduce anti-social behaviour in young offenders in prison.

Ethics approval

South East Research Ethics Committee, 11/09/2006, ref: 06/MREC01/47

Study design

Randomised placebo-controlled double-blind trial

Primary study design


Secondary study design

Randomised controlled trial

Trial setting


Trial type

Quality of life

Patient information sheet

Not available in web format, please use the contact details below to request a patient information sheet


Anti-social behaviour in prison


Food supplements (minerals, vitamins and essential fatty acids):
1. Forceval (Alliance Pharma plc): contains vitamin A (750 µg), vitamin D (10 µg), vitamin B1 (1.2 mg), vitamin B2 (1.6 mg), vitamin B6 (2 mg), vitamin B12 (3 µg), vitamin C (60 mg), vitamin E (10 mg), vitamin K1 (120 µg), biotin (100 µg), nicotinamide (18 mg), pantothenic acid (4 mg), folic acid (400 µg), calcium (100 mg), iron (12 mg), copper (2 mg), magnesium (30 mg), zinc (18 mg), iodine (140 µg), manganese (3 mg), potassium (4 mg), phosphorus (77 mg), selenium (50 µg), chromium (200 µg), molybdenum (250 µg). 1 capsule per day p.o. (by mouth).

2. Equazen: contains gamma linolenic acid (45 mg), eicosapentaenoic acid (EPA) (951 mg), docosahexaenoic acid (DHA) (147 mg), vitamin E (8.4 mg), magnesium (60 mg). 3 x 854 mg capsules daily by mouth.

Total duration of treatment: 4 months (maximum)
Total duration of follow-up: 1 month (for all treatment arms)

Intervention type



Not Applicable

Drug names

Vitamin, mineral and essential fatty acid supplementation

Primary outcome measure

Governor's reports (of violence and other offences), measured after 4 months treatment.

Secondary outcome measures

1. Blood levels of micronutrients, measured after 4 months treatment
2. Cambridge Neuropsychological Test Automated Battery (CANTAB) measures of impulsivity, attention, measured after 4 months treatment
3. Heart rate variability changes, measured after 4 months treatment

Overall trial start date


Overall trial end date


Reason abandoned (if study stopped)


Participant inclusion criteria

16 - 21 year old male offenders in prison

Participant type


Age group




Target number of participants


Participant exclusion criteria

1. Chronic medical conditions
2. Psychotropic medication

Recruitment start date


Recruitment end date



Countries of recruitment

United Kingdom

Trial participating centre

University of Oxford
United Kingdom

Sponsor information


University of Oxford (UK)

Sponsor details

Wellington Square
United Kingdom
+44 (0)1865 270011

Sponsor type




Funder type


Funder name

Wellcome Trust (grant ref: 078667)

Alternative name(s)

Funding Body Type

private sector organisation

Funding Body Subtype

International organizations


United Kingdom

Results and Publications

Publication and dissemination plan

Not provided at time of registration

Intention to publish date

Participant level data

Available on request

Basic results (scientific)

Publication list

Publication citations

Additional files

Editorial Notes

03/05/2016: No publications found, verifying study status with principal investigator.