Mrs Lisa Dyson
York Trials Unit
Ground Floor ARRC Building
Department of Health Sciences
University of York
Determining the optimal approach to identifying individuals with chronic obstructive pulmonary disease: a multi-centre randomised trial
1. To identify the most effective case-finding pathway for chronic obstructive pulmonary disease (COPD). The specific health service impacts across different possible pathways for undertaking COPD case finding amongst current smokers in primary care settings will be assessed.
2. To assess the cost-effectiveness of COPD case-finding pathways. A cost-per-true-positive-case-found analysis will be undertaken and health care resource use will be incorporated.
3. To evaluate the efficiency of the 'case finding' pathway. Key factors to consider will be the quality of the forced expiratory volume in one second (FEV1)/forced vital capacity (FVC), mechanical peak expiratory flow rate (PEFR) measurements and wheezometer measurements (in relation to the reference standard).
4. To evaluate whether undergoing the diagnostic test(s) has an impact on smoking behaviour to inform future smoking cessation studies.
On 16/06/2015 the overall trial end date was changed from 31/07/2012 to 01/09/2013.
Newcastle and North Tyneside 2 Research Ethics Committee, 29/07/2010, ref: 10/H0907/37
Multi-centre randomised trial
Primary study design
Secondary study design
Randomised controlled trial
Patient information sheet
Not available in web format, please use the contact details below to request a patient information sheet
Chronic obstructive pulmonary disease (COPD)
1. Participants will undertake lung function tests (i.e. peak flow measurement, microspirometry and post-bronchodilator spirometry), a wheeze-detecting device (i.e. wheezometer) and a case-finding questionnaire
2. Further questionnaires will be completed during the study; a screening questionnaire and a follow-up questionnaire.
All participants receive the case-finding tests, with half randomised to receive the tests straight away and the remainder will receive the tests approximately 6 months later.
Primary outcome measures
Effectiveness of diagnostic pathways - aim to identify the most effective pathway for use as the routine service model in primary care
Secondary outcome measures
1. Cost-effectiveness of COPD case-finding pathway
2. Efficiency of COPD case-finding pathway
3. Impact on smoking behaviour
Overall trial start date
Overall trial end date
Participant inclusion criteria
Current smokers aged 35 years or more who are registered with participating GP practices
Target number of participants
Participant exclusion criteria
2. Recent history (within 8 weeks) of myocardial infarction, stroke, pulmonary embolism, chest/abdominal surgery or eye surgery
3. Any mental or physical condition (e.g. chest/ abdominal pain/ stress incontinence) or any other condition which means the participant is unable to undergo the case-finding tools
Recruitment start date
Recruitment end date
Countries of recruitment
Trial participating centre
York Trials Unit
Department of Health (UK) - Respiratory Programme
Funding Body Type
Funding Body Subtype
Results and Publications
Publication and dissemination plan
The results are expected to be published in 2015
Intention to publish date
Participant level data
Not provided at time of registration
Results - basic reporting