Investigation of the effects and mechanisms of action of different wavelengths of ultraviolet B (UVB) radiation in the treatment of psoriasis
| ISRCTN | ISRCTN43688684 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN43688684 |
| Secondary identifying numbers | 5623; 079504 |
- Submission date
- 12/05/2010
- Registration date
- 12/05/2010
- Last edited
- 13/12/2019
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Skin and Connective Tissue Diseases
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Record updated in last year
Plain English summary of protocol
Not provided at time of registration
Contact information
Dr Sophie Weatherhead
Scientific
Scientific
Newcastle University
Dermatology
2nd Floor William Leech Building
Medical School
Newcastle
NE2 4HH
United Kingdom
Study information
| Study design | Single centre non-randomised interventional treatment trial |
|---|---|
| Primary study design | Interventional |
| Secondary study design | Non randomised controlled trial |
| Study setting(s) | Other |
| Study type | Treatment |
| Participant information sheet | Not available in web format, please use the contact details below to request a patient information sheet |
| Scientific title | Investigation of the effects and mechanisms of action of different wavelengths of ultraviolet B (UVB) radiation in the treatment of psoriasis: a single centre non-randomised treatment trial |
| Study acronym | MECH-UVB-PSOR |
| Study objectives | To test the hypothesis that keratinocyte apoptosis is an important mechanism of action of ultraviolet B (UVB) phototherapy in the clearance of psoriasis, and to investigate the correlation between effectiveness of different wavelengths of UV and apoptotic response in the clearance of psoriasis. |
| Ethics approval(s) | County Durham and Tees Valley (1) REC, ref: 06/Q1003/78 |
| Health condition(s) or problem(s) studied | Topic: Skin; Subtopic: Skin (all Subtopics); Disease: Dermatology |
| Intervention | Compare the apoptotic effect of different wavelengths of UVB in psoriatic epidermis in vivo. |
| Intervention type | Other |
| Primary outcome measure | Whether the number of apoptotic cells seen within the epidermis is sufficient to allow plaque remodelling. Measured up to 48 hours (4 hours, 8 hours, 12 hours,15 hours, 18 hours, 24 hours, and 48 hours). |
| Secondary outcome measures | 1. Effect of skin type 2. UV dose 3. Age and gender Measured up to 48 hours (4 hours, 8 hours, 12 hours,15 hours, 18 hours, 24 hours, and 48 hours). |
| Overall study start date | 01/10/2006 |
| Completion date | 30/04/2010 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Adult |
| Lower age limit | 18 Years |
| Sex | Both |
| Target number of participants | Planned sample size: 121 |
| Key inclusion criteria | 1. Aged 18 years and over, with no sex specific criteria 2. All patients who are prescribed routine UVB (TL01) for their psoriasis at our centre 3. Give informed consent to participate |
| Key exclusion criteria | 1. Aged under 18 years 2. Systemic immunosupression within 3 months 3. UVB exposure to lower back within 3 months of recruitment 4. Topical treatments other than emollients for 2 weeks |
| Date of first enrolment | 01/10/2006 |
| Date of final enrolment | 30/04/2010 |
Locations
Countries of recruitment
- England
- United Kingdom
Study participating centre
Newcastle University
Newcastle
NE2 4HH
United Kingdom
NE2 4HH
United Kingdom
Sponsor information
Newcastle upon Tyne Hospitals NHS Foundation Trust (UK)
Hospital/treatment centre
Hospital/treatment centre
Queen Victoria Road
Newcastle Upon Tyne
NE1 4LP
England
United Kingdom
| Website | http://www.newcastle-hospitals.org.uk/ |
|---|---|
"ROR" |
https://ror.org/05p40t847 |
Funders
Funder type
Charity
The Wellcome Trust (UK) (grant ref: 079504)
No information available
Results and Publications
| Intention to publish date | |
|---|---|
| Individual participant data (IPD) Intention to share | No |
| IPD sharing plan summary | Not provided at time of registration |
| Publication and dissemination plan | Not provided at time of registration |
| IPD sharing plan |
Editorial Notes
13/12/2019: No publications found, verifying study status with principal investigator.
09/05/2016: No publications found, verifying study status with principal investigator.
