Condition category
Urological and Genital Diseases
Date applied
Date assigned
Last edited
Retrospectively registered
Overall trial status
Recruitment status
No longer recruiting

Plain English Summary

Not provided at time of registration

Trial website

Contact information



Primary contact

Mrs Sharlene Greenwood


Contact details

Denmark Hill
United Kingdom

Additional identifiers

EudraCT number number

Protocol/serial number


Study information

Scientific title

The effect of resistance training and aerobic exercise on vascular stiffness, novel cardiovascular risk markers, aerobic capacity, muscle strength and incidence of complications in the first year of renal transplantation. A randomised controlled study


ExeRT Trial (EXErcise in Renal Transplant Trial)

Study hypothesis

Physical activity and exercise plays a beneficial role in maintaining the health in those with chronic illnesses however poor physical functioning among patients with chronic kidney disease is well-recognised. The use of modern immunosuppressant therapies have improved the life-expectancy of kidney grafts, however, risks of secondary complications such as diabetes, cardiovascular disease and obesity are an associated risk. It has been established that recipients of kidney transplants increase their physical activity level in the subsequent years after transplantation due to improved quality of life; however within that time they do not reach the level of physical activity of those of age matched healthy controls. Regular aerobic exercise helps to prevent and treat cardiovascular disease and to prevent and reverse arterial stiffening. Resistance training is also an important physical activity that can prevent or treat lifestyle-related diseases. However, high-intensity resistance training reduces arterial compliance and increases arterial stiffness, although this is not a universal finding. That is, regular aerobic exercise increases, whereas high-intensity resistance training decreases arterial compliance. This project will examine the effect and timing of aerobic exercise and resistance training exercise delivered in a 24-week supervised outpatient class setting, on vascular stiffness, aerobic capacity, functional ability, transplant outcomes and quality of life in patients who have received a kidney transplant. The project aims to provide evidence for the importance of exercise for patients that have received a kidney transplant and encourage the commissioning of physiotherapy services for this patient group.

Ethics approval


Study design

Randomised; Interventional; Design type: Not specified, Treatment

Primary study design


Secondary study design

Randomised controlled trial

Trial setting


Trial type


Patient information sheet

Not available in web format, please use contact details to request a participant information sheet


Topic: Renal disorders; Subtopic: Renal disorders; Disease: All Renal disorders


Aerobic training: AT will predominantly be on stationary exercise cycles at 80% hear rate reserve.
Resistance Training: Resistance training will use RT machines training large muscle groups (e.g. bench press, latissimus pulldown, bicep curl, triceps pull down,leg press, knee extension, hamstring curl, calf raises). Intensity will be 80% of 1RM, building up to 3 sets of 10 reps.; Study Entry : Single Randomisation only

Intervention type



Not Applicable

Drug names

Primary outcome measure

Pulse Wave Velocity (PWV); Timepoint(s): Baseline, 12 weeks and 12 months

Secondary outcome measures

1. CVD biomarkers - Fetuin A, TNF receptor 2, IL6, HS CRP; Timepoint(s): Baseline, 12 weeks and 12 months
2. Duke's Activity Status Index; Timepoint(s): Baseline and 12 weeks
3. Muscle strength (myometer); Timepoint(s): baseline and 12 weeks
4. Resting heart rate and blood pressure; Timepoint(s): baseline, 12 weeks and 12 months
5. Sit to stand 60; Timepoint(s): baseline and 12 weeks
6. VO2peak; Timepoint(s): baseline, 12 weeks and 12 months

Overall trial start date


Overall trial end date


Reason abandoned (if study stopped)


Participant inclusion criteria

1. All patients undergoing renal transplant
2. Male or female
3. Aged >18 years
4. Written informed consent; Target Gender: Male & Female ; Lower Age Limit 18 years

Participant type


Age group




Target number of participants

Planned Sample Size: 60; UK Sample Size: 60

Participant exclusion criteria

1. Requiring support for ambulation less than 20m
2. Vasculitis
3. Proliferative diabetic retinopathy,
4. Severe osteodystophy
5. Uncontrolled diabetes
6. Psychiatric illness, including anxiety, mood and untreated eating disorders
7. Infection or course of antibiotics within the last month

Recruitment start date


Recruitment end date



Countries of recruitment

United Kingdom

Trial participating centre

Denmark Hill
United Kingdom

Sponsor information


King's College Hospital NHS Foundation Trust (UK)

Sponsor details

Dept of Research & Development KCH
34 Love Walk
United Kingdom

Sponsor type

Hospital/treatment centre



Funder type


Funder name

NIHR Doctoral Research Fellowship; Grant Codes: NIHR-DRF-2012-05-874

Alternative name(s)

Funding Body Type

Funding Body Subtype


Results and Publications

Publication and dissemination plan

Not provided at time of registration

Intention to publish date

Participant level data

Not provided at time of registration

Basic results (scientific)

Publication list

2017 results in:

Publication citations

Additional files

Editorial Notes

The registration of this study was initiated on 22/08/2012, when it was confirmed as proceeding through the NIHR CSP (the system for gaining NHS permission for clinical research). The trialists state that the study details have not been amended in any way since this date. It was confirmed as eligible for inclusion in the UKCRN portfolio on 20/11/2012. The ISRCTN registry received the study for inclusion on the 30/07/2014 and registered the study on 31/07/2014. 06/02/2017: Publication reference added.