Drivers of eating behaviour during chronic overconsumption
ISRCTN | ISRCTN47291569 |
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DOI | https://doi.org/10.1186/ISRCTN47291569 |
Secondary identifying numbers | BB/G530141/1 |
- Submission date
- 14/09/2010
- Registration date
- 27/01/2011
- Last edited
- 15/03/2013
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Nutritional, Metabolic, Endocrine
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Plain English summary of protocol
Not provided at time of registration
Contact information
Prof John Blundell
Scientific
Scientific
Institute of Psychological Sciences
University of Leeds
Leeds
LS2 9JT
United Kingdom
Study information
Study design | SIngle centre medium term (12-week) experimental controlled study |
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Primary study design | Interventional |
Secondary study design | Non randomised controlled trial |
Study setting(s) | Other |
Study type | Other |
Participant information sheet | Not available in web format, please use contact details below to request a patient information sheet |
Scientific title | Drivers of eating behaviour during chronic overconsumption: role of food hedonics (liking and wanting) and peptide biomarkers on satiation and satiety |
Study objectives | The aim of this study follows on from the findings of our previous BBSRC grant (BBS/B/05079: The impact of physical activity on appetite control). Participants are involved in two concurrent sub-studies. Study 1, looks at changes at energy balance over the duration of the intervention. Study 2 looks at the kinetics of gut peptides after consumption of breakfast. During the exercise intervention in study 1, a proportion of participants are expected to show compensatory increases in energy intake which will offset the energy deficit. This relative overconsumption is safe because it does not result in significant weight gain, but does confer other health benefits such as increased fitness, lowered blood pressure, resting heart rate and reduced waist circumference (a marker of visceral fat). The principal objective of the study is to characterise and compare those participants who lose the amount of weight predicted by their exercise expenditure (based on measured changes in their fat and lean mass) with those participants who do not lose the amount of weight predicted. The outcomes of the study will yield important information about the processes that underpin eating behaviour during a prolonged elevation in food intake (relative overconsumption) in response to an increase in energy expenditure from exercise. |
Ethics approval(s) | UK National Health Service Research Ethics Committee Leeds (West) approved on the 20th January 2009 (ref: 09/H1307/7) |
Health condition(s) or problem(s) studied | Overweight, obesity |
Intervention | Supervised exercise to expend 500 kcal 5 times/week for 12 weeks. Assessments at week 0, week 6 and week 12. No exercise overweight/obese and lean comparators. |
Intervention type | Other |
Primary outcome measure | Study 1: Change in energy balance from week 0 to week 12 measured by the product of the energy cost of a unit change in fat mass by the observed change in fat mass and summing it with the product of the energy cost of a unit change in lean mass by the observed change in lean mass. Study 2: Rise and fall in concentration of gut peptides assayed from the participants blood samples in the four hour period following consumption of breakfast. |
Secondary outcome measures | Study 1: 1.1. Cardiovascular fitness at week 12 will be measured by VO2 maximal test of aerobic capacity 1.2. Resting heart rate and Blood pressure at week 12 will be measured by an integrated digital blood pressure and heart rate monitor with inflatable cuff 1.3. Resting metabolic rate at week 12 will be measured by Gas Exchange Measurement 1.4. Substrate oxidation at week 12 will be measured by indirect calorimetry 1.5. Eating behaviour at week 12 will be measured by intake of test meals designed to vary in macronutrient composition (20:65:15 and 35:50:15, % carbohydrate:fat:protein) and quantitative ratings of hunger and satiety by questionnaire Study 2: Quantitative ratings of hunger and satiety by questionnaire. |
Overall study start date | 28/01/2008 |
Completion date | 29/10/2015 |
Eligibility
Participant type(s) | Patient |
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Age group | Adult |
Lower age limit | 18 Years |
Sex | Both |
Target number of participants | 78 |
Key inclusion criteria | 1. 18 - 55 years old 2. Sedentary lifestyle (no leisure-time physical activity in previous 6 months) 3. Body Mass Index (BMI) between 27 - 38 kg/m2 or 18 - 23 kg/m2 (lean control) 4. Signed consent given 5. No objection from participant's GP |
Key exclusion criteria | 1. Inability to fully comply with intervention or study procedures 2. Insufficient English language skills to complete all questionnaires 3. Pre-existing injuries or conditions that could be aggravated by regular physical activity 4. Medication that could influence accumulation or expenditure of energy 5. Cardiac problems (arrhythmia, Congestive heart disease) 6. Uncontrolled hypertension 7. Genetic syndromes associated with obesity 8. Presence of untreated hypothyroidism 9. Recent body weight change (± 2 kg in previous 3 months) 10. Currently following weight loss regime 11. Food allergies or aversions |
Date of first enrolment | 28/01/2008 |
Date of final enrolment | 29/10/2015 |
Locations
Countries of recruitment
- England
- United Kingdom
Study participating centre
Institute of Psychological Sciences
Leeds
LS2 9JT
United Kingdom
LS2 9JT
United Kingdom
Sponsor information
University of Leeds (UK)
University/education
University/education
c/o Rachel De Souza
Leeds
LS2 9JT
England
United Kingdom
Website | http://www.leeds.ac.uk/ |
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https://ror.org/024mrxd33 |
Funders
Funder type
Research council
Biotechnology and Biological Sciences Research Council (BBSRC) (UK) - (ref: BB/G530141/1)
Government organisation / National government
Government organisation / National government
- Alternative name(s)
- UKRI - Biotechnology And Biological Sciences Research Council, BBSRC UK, BBSRC
- Location
- United Kingdom
Results and Publications
Intention to publish date | |
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Individual participant data (IPD) Intention to share | No |
IPD sharing plan summary | Not provided at time of registration |
Publication and dissemination plan | Not provided at time of registration |
IPD sharing plan |
Study outputs
Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
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Results article | results | 08/06/2011 | Yes | No | |
Results article | results | 01/02/2012 | Yes | No | |
Results article | results | 01/01/2013 | Yes | No |