Reducing antibiotic prescribing in respiratory illness
| ISRCTN | ISRCTN47558792 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN47558792 |
| Secondary identifying numbers | 086921; UKCRN ID: 7412 |
- Submission date
- 16/03/2010
- Registration date
- 17/03/2010
- Last edited
- 24/02/2015
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Respiratory
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Plain English summary of protocol
Not provided at time of registration
Contact information
Prof Martin Gulliford
Scientific
Scientific
Division of Health and Social Care Research
Division of Primary Care and Public Health
King's College London
6th Floor Capital House
42 Weston Street
London
SE1 3QD
United Kingdom
| martin.gulliford@kcl.ac.uk |
Study information
| Study design | Interventional multicentre cluster randomised controlled trial |
|---|---|
| Primary study design | Interventional |
| Secondary study design | Randomised controlled trial |
| Study setting(s) | GP practice |
| Study type | Other |
| Participant information sheet | Not available in web format, please use the contact details below to request a patient information sheet |
| Scientific title | Cluster randomised trial in a Primary Care database: utilising electronic patient records for intervention research into reducing antibiotic prescribing in respiratory illness |
| Study objectives | To test the effectiveness of an electronic record-based intervention at achieving a reduction in antibiotic prescribing at consultations for respiratory illness between the ages of ages 18 and 59 years in intervention practices as compared with controls. |
| Ethics approval(s) | London - Surrey Borders Research Ethics Committee, 21/12/2009, ref: 09/H0806/81 |
| Health condition(s) or problem(s) studied | Respiratory tract infection |
| Intervention | Electronic prompts have been developed based on recommended clinical practice guidelines to be activated during consultations for respiratory tract infection (RTI) in the selected age range. During consultations with patients presenting with symptoms of RTI, primary care professionals will see the prompts which remind them of recommended standards of care in RTI. The prompts will also provide them with supporting information and links to evidence that supports the recommendations. The decision on whether to follow the treatment suggestions included in the prompt, or whether to prescribe antibiotics, will be at the discretion of the GP. The GP will also be able to terminate display of the prompt at any time. As indicated above, the prompts will only be activated during consultations by patients aged 18 to 59 years. There will be no intervention at control practices. The intervention phase will continue for 12 months at each practice. |
| Intervention type | Other |
| Primary outcome measure | Proportion of RTI consultations with antibiotics prescribed over 12 months |
| Secondary outcome measures | Measured at 12 months follow-up: 1. Age- and sex-specific rates of RTI consultation 2. Age- and sex-specific proportion of RTI consultations with antibiotics prescribed 3. Occurrence of RTI complications |
| Overall study start date | 01/04/2010 |
| Completion date | 31/10/2011 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Adult |
| Lower age limit | 18 Years |
| Upper age limit | 59 Years |
| Sex | Both |
| Target number of participants | 50 GP practices per group (100 practices in total) |
| Key inclusion criteria | 1. Patients aged 18 - 59 years, either sex 2. Registered at the practice for at least 3 years at the trial start date 3. First diagnosis of stroke recorded in the 24-month period before the trial start date |
| Key exclusion criteria | Younger than 18 years and over the age of 59 years |
| Date of first enrolment | 01/04/2010 |
| Date of final enrolment | 31/10/2011 |
Locations
Countries of recruitment
- England
- United Kingdom
Study participating centre
Division of Health and Social Care Research
London
SE1 3QD
United Kingdom
SE1 3QD
United Kingdom
Sponsor information
The Wellcome Trust (UK)
Charity
Charity
Gibbs Building
215 Euston Road
London
NW1 2BE
United Kingdom
| contact@wellcome.ac.uk | |
| Website | http://www.wellcome.ac.uk/ |
"ROR" |
https://ror.org/029chgv08 |
Funders
Funder type
Charity
Wellcome Trust
Private sector organisation / International organizations
Private sector organisation / International organizations
- Location
- United Kingdom
Results and Publications
| Intention to publish date | |
|---|---|
| Individual participant data (IPD) Intention to share | No |
| IPD sharing plan summary | Not provided at time of registration |
| Publication and dissemination plan | Not provided at time of registration |
| IPD sharing plan |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Protocol article | protocol | 10/05/2011 | Yes | No | |
| Results article | results | 11/06/2014 | Yes | No | |
| Other publications | process evaluation | 03/12/2014 | Yes | No |
