Condition category
Circulatory System
Date applied
Date assigned
Last edited
Retrospectively registered
Overall trial status
Recruitment status
No longer recruiting

Plain English Summary

Not provided at time of registration

Trial website

Contact information



Primary contact

Dr Simon Murphy


Contact details

Cardiff Institute of Society and Health
School of Social Sciences
Cardiff University
CF10 3BD
United Kingdom

Additional identifiers

EudraCT number number

Protocol/serial number


Study information

Scientific title

A randomised controlled trial of the effectiveness of an exercise referral scheme in increasing physical activity in inactive men and women aged 16+ with coronary heart disease risk factors and / or mild to moderate depression, anxiety or stress


Study hypothesis

Is a national exercise referral scheme more effective in increasing on physical activity and improving mental health in inactive men and women aged 16+ with coronary heart disease risk factors and / or mild to moderate depression, anxiety or stress compared to the provision of an information leaflet and normal care at 12 months follow up?

Ethics approval

The Thames Valley Multi-centre Research Ethics Committee (MREC), 08/02/2007, ref: 06/MRE12/85

Study design

Single centre pragmatic randomised controlled trial with blind assignment to intervention (exercise referral) or control trial arm (normal care and leaflet) and masked intervention delivery

Primary study design


Secondary study design

Randomised controlled trial

Trial setting


Trial type


Patient information sheet

Not available in web format, please use contact details below to request a patient information sheet.


Coronary heart disease risk factors and / or mild to moderate depression, anxiety or stress


A 16 week intervention consisting of an initial and exit consultation with an exercise profession and access to weekly one to one discounted exercise instruction and/or group exercise classes for the period.

Participants in the control group receive a leaflet and normal care.

Intervention type



Not Applicable

Drug names

Primary outcome measures

Total minutes of weekly activity using the seven day physical activity recall questionnaire (7-DAY PAR)

Secondary outcome measures

The Hospital Anxiety and Depression Scale (HADS) to assess depression and anxiety, measured at 12 months

Overall trial start date


Overall trial end date


Reason abandoned


Participant inclusion criteria

Sedentary male and females aged 16+ with coronary heart disease risk factors and / or mild to moderate depression, anxiety or stress

Participant type


Age group




Target number of participants


Participant exclusion criteria

1. Unstable angina
2. Blood pressure 180/100 (in either) or above and/or uncontrolled or poorly controlled hypertension
3. Cardio myopathy
4. Uncontrolled tachycardia
5. Cardiac arrhythmia
6. Valvular heart disease
7. Congenital heart disease
8. Unexplained dizzy spells
9. Excessive or unexplained breathlessness on exertion
10. Uncontrolled or poorly controlled diabetes
11. Uncontrolled or poorly controlled epilepsy
12. History of falls or dizzy spells in the last 12 months
13. Uncontrolled or poorly controlled asthma (severe COPD)
14. First 12 weeks of pregnancy
15. Awaiting medical investigation
16. Aneurysms
17. Cerebro-vascular disease
18. Unstable/newly diagnosed angina (within 6 months)
19. Established coronary heart disease (including myocardial infarction)
20. Any other uncontrolled condition

Recruitment start date


Recruitment end date



Countries of recruitment

United Kingdom

Trial participating centre

Cardiff Institute of Society and Health
CF10 3BD
United Kingdom

Sponsor information


Welsh Assembly Government (UK)

Sponsor details

Social Research Division (Yr Is-Adran Ymchwil Gymdeithasol)
Department of the First Minister and Cabinet (Adran y Prif Weinidog a’r Cabinet)
Welsh Assembly Government (Llywodraeth Cynulliad Cymru)
CF10 3NQ
United Kingdom

Sponsor type




Funder type


Funder name

Welsh Assembly Government (UK) (tender contract number: 146/2005)

Alternative name(s)

Funding Body Type

Funding Body Subtype


Results and Publications

Publication and dissemination plan

Not provided at time of registration

Intention to publish date

Participant level data

Not provided at time of registration

Results - basic reporting

Publication summary

2010 protocol in:
2012 results in:
2013 results in:
2014 secondary analysis results in:

Publication citations

  1. Protocol

    Murphy S, Raisanen L, Moore G, Edwards RT, Linck P, Williams N, Ud Din N, Hale J, Roberts C, McNaish E, Moore L, A pragmatic randomised controlled trial of the Welsh National Exercise Referral Scheme: protocol for trial and integrated economic and process evaluation., BMC Public Health, 2010, 10, 352, doi: 10.1186/1471-2458-10-352.

  2. Results

    Murphy SM, Edwards RT, Williams N, Raisanen L, Moore G, Linck P, Hounsome N, Din NU, Moore L, An evaluation of the effectiveness and cost effectiveness of the National Exercise Referral Scheme in Wales, UK: a randomised controlled trial of a public health policy initiative., J Epidemiol Community Health, 2012, 66, 8, 745-753, doi: 10.1136/jech-2011-200689.

  3. Results

    Edwards RT, Linck P, Hounsome N, Raisanen L, Williams N, Moore L, Murphy S, Cost-effectiveness of a national exercise referral programme for primary care patients in Wales: results of a randomised controlled trial., BMC Public Health, 2013, 13, 1021, doi: 10.1186/1471-2458-13-1021.

  4. Secondary analysis results

    Littlecott HJ, Moore GF, Moore L, Murphy S, Psychosocial mediators of change in physical activity in the Welsh national exercise referral scheme: secondary analysis of a randomised controlled trial., Int J Behav Nutr Phys Act, 2014, 11, 1, 109, doi: 10.1186/s12966-014-0109-9.

Additional files

Editorial Notes