Contact information
Type
Scientific
Primary contact
Prof Juliana CN Chan
ORCID ID
Contact details
Dept of Medicine and Therapeutics
Chinese University of Hong Kong
The Prince of Wales Hospital
Shatin
-
-
Hong Kong
+852 (0)2632 3138
jchan@cuhk.edu.hk
Additional identifiers
EudraCT number
ClinicalTrials.gov number
Protocol/serial number
HSRC/HCPF226103
Study information
Scientific title
Acronym
Study hypothesis
To investigate the effects of compliance and periodic telephone counselling by a pharmacist on mortality in patients receiving polypharmacy.
Ethics approval
Added as of 22/10/2007:
Ethics approval received from the Chinese University of Hong Kong clinical research ethics committee.
Study design
Randomised controlled trial
Primary study design
Interventional
Secondary study design
Randomised controlled trial
Trial setting
Not specified
Trial type
Treatment
Patient information sheet
Condition
Compliance to polypharmacy
Intervention
Patients randomised to the intervention group received a 10 - 15 minute telephone call from the pharmacist for education and counselling between clinic visits for 2 years. Patients in the control group did not receive any telephone reminders.
Intervention type
Other
Phase
Not Specified
Drug names
Primary outcome measure
Time from randomisation to death from any cause.
Secondary outcome measures
1. Changes in the rate of admission to hospital
2. Number of emergency room visits
3. Hospital stay in the two years before and after the screening visit
4. Changes in compliance
Overall trial start date
01/10/1998
Overall trial end date
01/06/1999
Reason abandoned (if study stopped)
Eligibility
Participant inclusion criteria
Patients receiving polypharmacy defined as five or more chronic medications who were found to be non-compliant upon first assessment by pharmacist
Participant type
Patient
Age group
Adult
Gender
Both
Target number of participants
Added as of 22/10/2007: 502 recruited
Participant exclusion criteria
1. Speak non-Cantonese dialects or a different language
2. Conditions that prevented effective communication (for example, patients who are deaf, mute, or have dementia or other psychological disorders)
3. Live in nursing homes with supervised treatment
Recruitment start date
01/10/1998
Recruitment end date
01/06/1999
Locations
Countries of recruitment
Hong Kong
Trial participating centre
Dept of Medicine and Therapeutics
-
-
Hong Kong
Sponsor information
Organisation
Hong Kong Health Services Research Fund (Hong Kong)
Sponsor details
Health Welfare and Food Bureau
Government Secretariat
HKSAR
20th floor Murray Building
Garden Road
-
-
Hong Kong
+852 (0)2973 8288
hsrf@hwfb.gov.hk
Sponsor type
Government
Website
Funders
Funder type
Government
Funder name
Hong Kong SAR Government Health Services Research Committee (Hong Kong)
Alternative name(s)
Funding Body Type
Funding Body Subtype
Location
Results and Publications
Publication and dissemination plan
Not provided at time of registration
Intention to publish date
Participant level data
Not provided at time of registration
Basic results (scientific)
Publication list
Results in http://www.ncbi.nlm.nih.gov/pubmed/16916809
Publication citations
-
Results
Wu JY, Leung WY, Chang S, Lee B, Zee B, Tong PC, Chan JC, Effectiveness of telephone counselling by a pharmacist in reducing mortality in patients receiving polypharmacy: randomised controlled trial., BMJ, 2006, 333, 7567, 522, doi: 10.1136/bmj.38905.447118.2F.