Screening-homes to prevent malaria
| ISRCTN | ISRCTN51184253 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN51184253 |
| Protocol serial number | G0400031 |
| Sponsor | Medical Research Council Laboratories (The Gambia) |
| Funder | Medical Research Council (MRC) (UK) |
- Submission date
- 27/06/2006
- Registration date
- 31/08/2006
- Last edited
- 25/09/2009
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Infections and Infestations
Plain English summary of protocol
Not provided at time of registration
Contact information
Scientific
School of Biological and Biomedical Sciences
University of Durham
South Road
Durham
DH1 3LE
United Kingdom
| S.W.Lindsay@durham.ac.uk |
Study information
| Primary study design | Interventional |
|---|---|
| Study design | Randomised controlled trial |
| Secondary study design | Randomised controlled trial |
| Scientific title | |
| Study objectives | A randomised-controlled trial will be conducted in Farafenni town in The Gambia to assess whether screening windows, doors and eaves or installing netting ceilings to local houses can substantially reduce exposure to malaria vectors compared to homes with no screening. Risk of malaria transmission will be assessed in each house by routine collections of mosquitoes using light traps and identifying which of the vectors are carrying malaria parasites. The acceptability of the interventions will be assessed through focus groups and questionnaires. Experimental huts will be used to determine whether any additional benefit can be achieved by impregnating torn screens with insecticide. Therefore, the aims of this study are to: 1. Determine whether house screening will reduce house-entry by malaria mosquitoes by 50% in Gambian homes 2. Assess whether the protection differs in the two types of screening by more than 17% 3. Determine whether house screening will reduce severe anaemia by 50% in children sleeping in these homes 4. Find out whether these interventions are comfortable, durable and acceptable to local communities 5. Assess whether insecticide-treatment of the screens prolong protection if the screens are torn |
| Ethics approval(s) | House screening intervention reviewed and approved by Gambian Government and Medical Research Council Laboratories Joint Ethics Committee (30/10/2004) and Durham University Ethics Advisory Committee (18/05/2005). The anaemia prevalence study was reviewed and approved by the same committees on 10/02/2006 and 27/03/2006 respectively. |
| Health condition(s) or problem(s) studied | Malaria |
| Intervention | This is a three-armed trial comprising of two screening interventions (full screening of 200 homes and netting ceilings of 200 homes) and a control group without screening of 100 homes. |
| Intervention type | Other |
| Primary outcome measure(s) |
1. Number of female mosquitoes (Anopheles gambiae) s.l./light trap/night |
| Key secondary outcome measure(s) |
Added as of 22/02/2007: |
| Completion date | 31/10/2008 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Not Specified |
| Sex | All |
| Target sample size at registration | 500 |
| Key inclusion criteria | Homes in Farafenni town and surrounding peri-urban villages in which at least one child sleeps. |
| Key exclusion criteria | Houses that are: 1. More than a single storey 2. More than four rooms or that have a ceiling, screening or closed eaves |
| Date of first enrolment | 01/05/2005 |
| Date of final enrolment | 31/10/2008 |
Locations
Countries of recruitment
- United Kingdom
- England
- Gambia
Study participating centre
DH1 3LE
United Kingdom
Results and Publications
| Individual participant data (IPD) Intention to share | No |
|---|---|
| IPD sharing plan summary | Not provided at time of registration |
| IPD sharing plan |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Results article | results | 19/09/2009 | Yes | No |
