Screening-homes to prevent malaria
| ISRCTN | ISRCTN51184253 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN51184253 |
| Secondary identifying numbers | G0400031 |
- Submission date
- 27/06/2006
- Registration date
- 31/08/2006
- Last edited
- 25/09/2009
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Infections and Infestations
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Plain English summary of protocol
Not provided at time of registration
Contact information
Prof S Lindsay
Scientific
Scientific
School of Biological and Biomedical Sciences
University of Durham
South Road
Durham
DH1 3LE
United Kingdom
| S.W.Lindsay@durham.ac.uk |
Study information
| Study design | Randomised controlled trial |
|---|---|
| Primary study design | Interventional |
| Secondary study design | Randomised controlled trial |
| Study setting(s) | Other |
| Study type | Prevention |
| Scientific title | |
| Study objectives | A randomised-controlled trial will be conducted in Farafenni town in The Gambia to assess whether screening windows, doors and eaves or installing netting ceilings to local houses can substantially reduce exposure to malaria vectors compared to homes with no screening. Risk of malaria transmission will be assessed in each house by routine collections of mosquitoes using light traps and identifying which of the vectors are carrying malaria parasites. The acceptability of the interventions will be assessed through focus groups and questionnaires. Experimental huts will be used to determine whether any additional benefit can be achieved by impregnating torn screens with insecticide. Therefore, the aims of this study are to: 1. Determine whether house screening will reduce house-entry by malaria mosquitoes by 50% in Gambian homes 2. Assess whether the protection differs in the two types of screening by more than 17% 3. Determine whether house screening will reduce severe anaemia by 50% in children sleeping in these homes 4. Find out whether these interventions are comfortable, durable and acceptable to local communities 5. Assess whether insecticide-treatment of the screens prolong protection if the screens are torn |
| Ethics approval(s) | House screening intervention reviewed and approved by Gambian Government and Medical Research Council Laboratories Joint Ethics Committee (30/10/2004) and Durham University Ethics Advisory Committee (18/05/2005). The anaemia prevalence study was reviewed and approved by the same committees on 10/02/2006 and 27/03/2006 respectively. |
| Health condition(s) or problem(s) studied | Malaria |
| Intervention | This is a three-armed trial comprising of two screening interventions (full screening of 200 homes and netting ceilings of 200 homes) and a control group without screening of 100 homes. |
| Intervention type | Other |
| Primary outcome measure | 1. Number of female mosquitoes (Anopheles gambiae) s.l./light trap/night 2. Haemoglobin density (g/dl) |
| Secondary outcome measures | Added as of 22/02/2007: 1. Prevalence of severe anaemia (defined as haemoglobin less than or equal to 8 g/dL) 2. Proportion of children with maleria parasites (Plasmodium falciparum prevalence) 3. Prevalence of high parasitemia (defined as equal to or greater than 5000 parasites/ul 4. Sporozoite rate estimations in trapped mosquitoes 5. Estimated entomological inoculation rate (EIR) i.e. mean number of sporozoite infective mosquitoes/house/season 6. Acceptability 7. Average indoor nightly temprature 8. Average rate of evaportaion indoors at night 9. Qualitative data from focus group discussions with household members 10. Proportion of residents willing to contimue use of intervention 11. Proportion of residents willing to invest in intervention installation 12. Durability 13. Number of screens showing damage at 6 and 12 months after installation 14. Other 15. Number of Culex quinquefasciatus /light trap/night |
| Overall study start date | 01/05/2005 |
| Completion date | 31/10/2008 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Not Specified |
| Sex | Both |
| Target number of participants | 500 homes |
| Key inclusion criteria | Homes in Farafenni town and surrounding peri-urban villages in which at least one child sleeps. |
| Key exclusion criteria | Houses that are: 1. More than a single storey 2. More than four rooms or that have a ceiling, screening or closed eaves |
| Date of first enrolment | 01/05/2005 |
| Date of final enrolment | 31/10/2008 |
Locations
Countries of recruitment
- England
- Gambia
- United Kingdom
Study participating centre
School of Biological and Biomedical Sciences
Durham
DH1 3LE
United Kingdom
DH1 3LE
United Kingdom
Sponsor information
Medical Research Council Laboratories (The Gambia)
Research council
Research council
Fajara
Banjul
-
Gambia
| tcorrah@mrc.gm | |
"ROR" |
https://ror.org/025wfj672 |
Funders
Funder type
Research council
Medical Research Council (MRC) (UK)
Government organisation / National government
Government organisation / National government
- Alternative name(s)
- Medical Research Council (United Kingdom), UK Medical Research Council, MRC
- Location
- United Kingdom
Results and Publications
| Intention to publish date | |
|---|---|
| Individual participant data (IPD) Intention to share | No |
| IPD sharing plan summary | Not provided at time of registration |
| Publication and dissemination plan | Not provided at time of registration |
| IPD sharing plan |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Results article | results | 19/09/2009 | Yes | No |
