Additional identifiers
EudraCT number
ClinicalTrials.gov number
Protocol/serial number
075930
Study information
Scientific title
A cluster randomised controlled trial of household-based insecticide treated window curtains and water jar covers for control of the dengue vector Aedes aegypti in the community
Acronym
DENCO Venezuela
Study hypothesis
We investigated whether window curtains and covers for domestic water storage containers, both made from long-lasting insecticide-treated netting and deployed either separately or in combination, could reduce populations of Aedes aegypti, the mosquito vector of dengue, to levels that could reduce dengue virus transmission in treated communities.
Ethics approval
1. Research Ethics Committee of the Liverpool School of Tropical Medicine approved on the 2nd February 2006 (ref: 06/12)
2. Bio-ethical committee of the Jose Witremundo Torrealba Research Institute, Trujillo, Venezuela, approved on the 18th June 2006
Study design
Cluster-randomised controlled trial
Primary study design
Interventional
Secondary study design
Randomised controlled trial
Trial setting
Other
Trial type
Prevention
Patient information sheet
Not available in web format, please use the contact details below to request a patient information sheet
Condition
Dengue (including Dengue Haemorrhagic Fever [DHF] and Dengue Shock Syndrome [DSS])
Intervention
Curtains made from deltamethrin-coated polyester netting (Long Lasting Impregnated netting; PermaNet® Vestergaard-Frandsen, Lausanne, Switzerland), hung in all outer windows regardless of the presence or absence of other window coverings (World Health Organization Pesticide Evaluation Scheme [WHOPES], approved material for indoor use).
Insecticide-treated water storage container covers are provided as ready-to-use products (a pre-packaged standard size with elasticated border, to close round the water container rim). Treated households provided with enough covers for all large household receptacles that hold water for longer than 1 week (it is from these containers that most Aedes aegypti emerge).
Control households received no treatment.
Following introduction of ITMs, the total duration of both intervention and follow-up was 26 months.
Intervention type
Other
Phase
Not Applicable
Drug names
Primary outcome measures
Entomological outcomes, the standard larval indices for the Aedes aegypti mosquito vector of dengue:
1. Breteau index: number of containers with immature stages per 100 houses
2. House index: number of houses containing immature stages per 100 houses
3. Container index: number of containers with immature stages per 100 containers with water
4. Pupal surveys were also undertaken to calculate the number of pupae per person index (number of pupae collected/human population in a sector)
Follow up surveys made to all houses at 1, 18, 24, 26 months post-intervention. Analyses to measure impact of the intervention on dengue vector populations will be undertaken according to intention to treat and per protocol (based on extent of coverage as determined in follow-up surveys).
Secondary outcome measures
1. Seroconversion rates (as measured by IgM ELISA) in households in the treated and control sectors compared at baseline and at the trial's end. Members of each household between 2 - 8 years of age specifically selected for the study.
2. Interview surveys used to determine:
2.1. Household characteristics
2.2. Previous vector control intervention
2.3. Better understanding of the local population's knowledge, attitudes and practice about previous methods of dengue prevention and control, and about ITMs for the same purpose
3. Insecticide-susceptibility assays undertaken before, at follow-up surveys and after intervention
Each house was also georeferenced with a handheld global positioning system receiver to permit subsequent overspill effects between adjacent treated and control clusters to be quantified.
Overall trial start date
01/07/2006
Overall trial end date
31/10/2008
Reason abandoned
Eligibility
Participant inclusion criteria
All occupied households
Participant type
Patient
Age group
Other
Gender
Both
Target number of participants
7,500 households
Participant exclusion criteria
1. Business-only premises
2. Multi-storey buildings
Recruitment start date
01/07/2006
Recruitment end date
31/10/2008
Locations
Countries of recruitment
Venezuela
Trial participating centre
Liverpool School of Tropical Medicine
Liverpool
L3 5QA
United Kingdom
Sponsor information
Organisation
Liverpool School of Tropical Medicine (UK)
Sponsor details
Pembroke Place
Liverpool
L3 5QA
United Kingdom
Sponsor type
Research organisation
Website
Funders
Funder type
Government
Funder name
European Union (EU) (Belgium) - Sixth Framework Programme (FP6): INCO-DEV-2 (ref: PL 517708)
Alternative name(s)
Funding Body Type
Funding Body Subtype
Location
Funder name
The Wellcome Trust (UK) (grant ref: 075930)
Alternative name(s)
Funding Body Type
Funding Body Subtype
Location
Results and Publications
Publication and dissemination plan
Not provided at time of registration
Intention to publish date
Participant level data
Not provided at time of registration
Results - basic reporting
Publication summary