Can the presence of insecticide treated materials in the household control dengue vectors?
ISRCTN | ISRCTN52339690 |
---|---|
DOI | https://doi.org/10.1186/ISRCTN52339690 |
Secondary identifying numbers | 075930 |
- Submission date
- 17/03/2010
- Registration date
- 18/03/2010
- Last edited
- 19/02/2020
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Infections and Infestations
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Plain English summary of protocol
Not provided at time of registration
Contact information
Dr Philip McCall
Scientific
Scientific
Liverpool School of Tropical Medicine
Liverpool
L3 5QA
United Kingdom
Study information
Study design | Cluster-randomised controlled trial |
---|---|
Primary study design | Interventional |
Secondary study design | Randomised controlled trial |
Study setting(s) | Other |
Study type | Prevention |
Participant information sheet | Not available in web format, please use the contact details below to request a patient information sheet |
Scientific title | A cluster randomised controlled trial of household-based insecticide treated window curtains and water jar covers for control of the dengue vector Aedes aegypti in the community |
Study acronym | DENCO Venezuela |
Study objectives | We investigated whether window curtains and covers for domestic water storage containers, both made from long-lasting insecticide-treated netting and deployed either separately or in combination, could reduce populations of Aedes aegypti, the mosquito vector of dengue, to levels that could reduce dengue virus transmission in treated communities. |
Ethics approval(s) | 1. Research Ethics Committee of the Liverpool School of Tropical Medicine approved on the 2nd February 2006 (ref: 06/12) 2. Bio-ethical committee of the Jose Witremundo Torrealba Research Institute, Trujillo, Venezuela, approved on the 18th June 2006 |
Health condition(s) or problem(s) studied | Dengue (including Dengue Haemorrhagic Fever [DHF] and Dengue Shock Syndrome [DSS]) |
Intervention | Curtains made from deltamethrin-coated polyester netting (Long Lasting Impregnated netting; PermaNet® Vestergaard-Frandsen, Lausanne, Switzerland), hung in all outer windows regardless of the presence or absence of other window coverings (World Health Organization Pesticide Evaluation Scheme [WHOPES], approved material for indoor use). Insecticide-treated water storage container covers are provided as ready-to-use products (a pre-packaged standard size with elasticated border, to close round the water container rim). Treated households provided with enough covers for all large household receptacles that hold water for longer than 1 week (it is from these containers that most Aedes aegypti emerge). Control households received no treatment. Following introduction of ITMs, the total duration of both intervention and follow-up was 26 months. |
Intervention type | Other |
Primary outcome measure | Entomological outcomes, the standard larval indices for the Aedes aegypti mosquito vector of dengue: 1. Breteau index: number of containers with immature stages per 100 houses 2. House index: number of houses containing immature stages per 100 houses 3. Container index: number of containers with immature stages per 100 containers with water 4. Pupal surveys were also undertaken to calculate the number of pupae per person index (number of pupae collected/human population in a sector) Follow up surveys made to all houses at 1, 18, 24, 26 months post-intervention. Analyses to measure impact of the intervention on dengue vector populations will be undertaken according to intention to treat and per protocol (based on extent of coverage as determined in follow-up surveys). |
Secondary outcome measures | 1. Seroconversion rates (as measured by IgM ELISA) in households in the treated and control sectors compared at baseline and at the trial's end. Members of each household between 2 - 8 years of age specifically selected for the study. 2. Interview surveys used to determine: 2.1. Household characteristics 2.2. Previous vector control intervention 2.3. Better understanding of the local population's knowledge, attitudes and practice about previous methods of dengue prevention and control, and about ITMs for the same purpose 3. Insecticide-susceptibility assays undertaken before, at follow-up surveys and after intervention Each house was also georeferenced with a handheld global positioning system receiver to permit subsequent overspill effects between adjacent treated and control clusters to be quantified. |
Overall study start date | 01/07/2006 |
Completion date | 31/10/2008 |
Eligibility
Participant type(s) | Patient |
---|---|
Age group | Other |
Sex | Both |
Target number of participants | 7,500 households |
Total final enrolment | 1122 |
Key inclusion criteria | All occupied households |
Key exclusion criteria | 1. Business-only premises 2. Multi-storey buildings |
Date of first enrolment | 01/07/2006 |
Date of final enrolment | 31/10/2008 |
Locations
Countries of recruitment
- England
- United Kingdom
- Venezuela
Study participating centre
Liverpool School of Tropical Medicine
Liverpool
L3 5QA
United Kingdom
L3 5QA
United Kingdom
Sponsor information
Liverpool School of Tropical Medicine (UK)
Research organisation
Research organisation
Pembroke Place
Liverpool
L3 5QA
United Kingdom
Website | http://www.lstmliverpool.ac.uk |
---|---|
https://ror.org/03svjbs84 |
Funders
Funder type
Government
European Union (EU) (Belgium) - Sixth Framework Programme (FP6): INCO-DEV-2 (ref: PL 517708)
No information available
The Wellcome Trust (UK) (grant ref: 075930)
No information available
Results and Publications
Intention to publish date | |
---|---|
Individual participant data (IPD) Intention to share | No |
IPD sharing plan summary | Not provided at time of registration |
Publication and dissemination plan | Not provided at time of registration |
IPD sharing plan |
Study outputs
Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
---|---|---|---|---|---|
Results article | results | 27/05/2006 | 19/02/2020 | Yes | No |
Editorial Notes
19/02/2020: The following changes have been made:
1. Publication reference added.
2. The final enrolment number has been added from the reference.