Working memory in children with attention-deficit/hyperactivity disorder (ADHD): the impact of methylphenidate (MPH)

ISRCTN	ISRCTN52376787
DOI	https://doi.org/10.1186/ISRCTN52376787
Secondary identifying numbers	RBP 98X24

Submission date: 23/01/2004
Registration date: 23/01/2004
Last edited: 12/12/2019

Recruitment status: No longer recruiting
Overall study status: Completed
Condition category: Mental and Behavioural Disorders

Prospectively registered

Protocol

Statistical analysis plan

Results

Individual participant data

Record updated in last year

Plain English summary of protocol

Not provided at time of registration

Contact information

Dr Kim Cornish
Scientific

Developmental Psychiatry
Division of Psychiatry
E Floor, South Block
South Block
Queens Medical Centre
Nottingham
NG7 2UH
United Kingdom

Phone	+44 (0)115 924 9924
Email	kim.cornish@mcgill.ca

Study information

Study design	Randomised controlled trial
Primary study design	Interventional
Secondary study design	Randomised controlled trial
Study setting(s)	Hospital
Study type	Treatment
Participant information sheet	Not available in web format, please use the contact details below to request a patient information sheet
Scientific title	Working memory in children with attention-deficit/hyperactivity disorder (ADHD): the impact of methylphenidate (MPH)
Study objectives	To address the following questions: What are the effects of methylphenidate on working memory in children with ADHD? Is there evidence for differential effects of MPH on working memory function? What is the relationship between the effects of MPH on working memory, behavioural inhibition, non-executive memory performance and hyperactive/impulsive behaviour?
Ethics approval(s)	Not provided at time of registration
Health condition(s) or problem(s) studied	Behavioural disorders
Intervention	1. Methylphenidate (MPH) treatment 2. No methylphenidate treatment
Intervention type	Other
Primary outcome measure	1. Information about effects of MPH on cognitive function (including the possibility of cognitive toxicity) in children with ADHD 2. Greater understanding of the underlying cognitive processes in ADHD This knowledge of underlying mechanisms will lead to improved specificity of early detection, diagnosis and treatment of ADHD 3. Identification of potential cognitive deficits in ADHD. If persisting cognitive deficits are identified. These will be rational targets for supplementary treatment interventions 4. Suggestion of tests to monitor the effects of MPH on cognitive function which could be developed for use in everyday clinical practice.
Secondary outcome measures	Not provided at time of registration
Overall study start date	01/09/1998
Completion date	29/02/2000

Eligibility

Participant type(s)	Patient
Age group	Child
Lower age limit	7 Years
Upper age limit	12 Years
Sex	Male
Target number of participants	60
Key inclusion criteria	60 boys aged between 7-12 years, receiving MPH, with a diagnosis of Hyperkinetic disorder or the equivalent ADHD combined sub-type, will be recruited from out-patient psychiatric clinics in the Trent region.
Key exclusion criteria	Does not match inclusion criteria
Date of first enrolment	01/09/1998
Date of final enrolment	29/02/2000

Locations

Countries of recruitment

England
United Kingdom

Study participating centre

Queens Medical Centre

Nottingham
NG7 2UH
United Kingdom

Sponsor information

NHS R&D Regional Programme Register - Department of Health (UK)
Government

The Department of Health
Richmond House
79 Whitehall
London
SW1A 2NL
United Kingdom

Phone	+44 (0)20 7307 2622
Email	dhmail@doh.gsi.org.uk
Website	http://www.doh.gov.uk

Funders

Funder type

Hospital/treatment centre

NHS Executive Trent (UK)

No information available

Results and Publications

Intention to publish date
Individual participant data (IPD) Intention to share	No
IPD sharing plan summary	Not provided at time of registration
Publication and dissemination plan	Not provided at time of registration
IPD sharing plan

Editorial Notes

12/12/2019: No publications found, verifying study status with principal investigator.
14/03/2016: No publications found, verifying study status with principal investigator