Condition category
Signs and Symptoms
Date applied
Date assigned
Last edited
Retrospectively registered
Overall trial status
Recruitment status
No longer recruiting

Plain English Summary

Background and study aims
Neck pain is a very common condition, which can be cause great discomfort and restriction of movement. Patients with neck pain often have visual problems however the reason for this is unknown. One possibility is that the amount of neck movement a person undertakes can influence the eye function. Many patients with neck pain may move their necks less to avoid pain, which may be causing the visual problems. The aim of this study is to look at whether a lot of movement or restricted movement of the neck has an effect on eye function in healthy people with no neck pain, to try to find the out if there is link between neck movement and visual problems.

Who can participate?
Adults with no neck pain who are able to move their necks freely and normal or corrected-to-normal vision.

What does the study involve?
Participants are randomly allocated to undertake two tests spaced one week apart in a different order. Before and 20 minutes after each test, participants have their eye function (measuring of the eye stabilization reflexes) measured. One test involves moving the neck around extensively for 20 minutes. The other test involves wearing a stiff neck collar that restricts movement for one hour.
The measurement of eye function will be in a darkened room and lasts around 20 minutes. It involves having to look straight forward while the chair they are sitting on is rotating, while the position of their eyes is measured with an infrared eye tracking device. Two weeks later, 11 participants return to repeat the condition with the neck collar, after wearing it for two hours. The eye function tests are repeated before and 20 minutes after wearing the collar.

What are the possible benefits and risks of participating?
There are no direct benefits for participants taking part in this study.

Where is the study run from?
Erasmus MC (Netherlands)

When is the study starting and how long is it expected to run for?
August 2014 to May 2015

Who is funding the study?
Erasmus MC (Netherlands)

Who is the main contact?
Miss Britta Ischebeck

Trial website

Contact information



Primary contact

Mrs Britta Ischebeck


Contact details

Department of Neuroscience
Erasmus MC
's-Gravendijkwal 230
3015 CE
+31 10 4642211

Additional identifiers

EudraCT number number

Protocol/serial number


Study information

Scientific title

The influence of cervical movement on eye stabilization reflexes: a randomized cross-over trial


Study hypothesis

The aim of this study is to investigate the influence of the amount of cervical movement on the cervico-ocular reflex (COR) and vestibulo-ocular reflex (VOR) in healthy individuals.

Ethics approval

Ethical board of the Erasmus MC, 19/07/2011, ref: MEC-2011-273

Study design

Single-centre randomised cross-over trial

Primary study design


Secondary study design

Randomised cross over trial

Trial setting


Trial type


Patient information sheet

No participant information sheet available.


Neck pain


In the main experiment, two types of intervention are applied to all participants in a cross-over design: hypokinesia and hyperkinesia. Directly before and after the intervention, the eye stabilization reflexes and the active range of motion are measured.

In the hypokinesia intervention, the neck is immobilized by using a stiff neck collar (size 4, Laerdal Stifneck® Select™) for one hour.

In the hyperkinesia intervention, active neck movement in all possible directions of movement is evoked by having the participants move their neck excessively in all directions for twenty minutes.

Each participant receives both interventions on two different days separated by 6 or 7 days. The order of the two interventions was pseudo-randomized and balanced across participants.

In the replication experiment, eleven participants wear the neck collar for two hours (prolonged hypokinesia). This experiment takes place two weeks after the end of the main experiment.

Intervention type



Drug names

Primary outcome measures

Amplitude of the cervico- ocular reflex (COR) and vestibulo-ocular reflex (VOR) is measured with a rotational chair with infrared eye tracking device pre and post each intervention.

Secondary outcome measures

The amount of the active cervical range of motion (CROM) in both the horizontal and vertical plane was also measured device (Performance Attainments Associates, USA) pre and post each intervention.

Overall trial start date


Overall trial end date


Reason abandoned


Participant inclusion criteria

1. 18 years of older
2. No neck pain
3. Able to move their neck
4. Able to sit on a chair for 20 minutes
5. Normal or corrected-to-normal visual acuity

Participant type

Healthy volunteer

Age group




Target number of participants


Participant exclusion criteria

1. Neck pain
2. History of neck trauma
3. Use of tranquilizing medication

Recruitment start date


Recruitment end date



Countries of recruitment


Trial participating centre

Erasmus MC
Department of Neuroscience 's-Gravendijkwal 230
3015 CE

Sponsor information


Erasmus MC

Sponsor details

's-Gravendijkwal 230
3015 CE
+31 10 4642211

Sponsor type




Funder type

Hospital/treatment centre

Funder name

Erasmus Medisch Centrum

Alternative name(s)

Erasmus Medical Center, Erasmus MC

Funding Body Type

private sector organisation

Funding Body Subtype




Results and Publications

Publication and dissemination plan

The authors intend to publish the results of the study in the autumn of 2016 in the journal 'Archives of Physical Medicine and Rehabilitation'

Intention to publish date


Participant level data

Available on request

Results - basic reporting

Publication summary

Publication citations

Additional files

Editorial Notes