Condition category
Date applied
Date assigned
Last edited
Prospectively registered
Overall trial status
Recruitment status
Not yet recruiting

Plain English Summary

Background and study aims
Breathing causes the trunk (torso) and ribcage to move. In some cases, this movement can cause unsteadiness and changes in posture and gait (pattern of movement of the limbs while moving). In order to better understand the way that posture changes during breathing, this study will look at the mechanics of breathing and what effect this has on the way a person moves. The aim of this study is to find out whether posture is influenced by breathing and the mechanism by which this happens.

Who can participate?
Healthy French adults.

What does the study involve?
All participants attend a single study visit which takes around four hours. At the visit, the participant’s posture is measured by taking a series of pictures taken using low dose x-rays while they are breathing calmly, after taking a deep breath and after breathing out fully in both sitting and standing positions. The participants then have 78 reflective markers attached to their whole body so that their motion can be monitored to assess their posture, and complete five different breathing patterns for one minute each in a standing position and then a sitting position. This involves quiet breathing with open eyes and mouth, closed eyes and open mouth, open eyes and closed mouth, closed eyes and mouth, and finally quiet breathing for 30 seconds with eyes open, followed by holding the breath for 10-15 sections and then deep breathing for 30 sections. Participants also take part in a walking test to measure their gait speed and have their lung volume measured by blowing into a machine called a spirometer.

What are the possible benefits and risks of participating?
There are no direct benefits or risks involved with participating in this study.

Where is the study run from?
1. Laboratoire de biomécanique humaine Georges charpak Arts et Métiers ParisTech (France)
2. Hôpital Pitié-Salpêtrière (France)

When is the study starting and how long is it expected to run for?
November 2014 to October 2019

Who is funding the study?
National School of Arts and Trades (France)

Who is the main contact?
Dr Valeria Attali

Trial website

Contact information



Primary contact

Dr Valerie Attali


Contact details

Pitié-Salpêtrière Hospital
47-83 Boulevard de l'Hôpital
+33 1 44964032

Additional identifiers

EudraCT number

2016-001243-39 number

Protocol/serial number


Study information

Scientific title

Postural adaptations linked to respiration in healthy and in respiratory diseases


Study hypothesis

Posture is influenced by respiration.

Ethics approval

Comité de Protection des Personnes Ile-de-France VI, 18/02/2015, ref: RCB 2006-A00386-45

Study design

Non-randomised study

Primary study design


Secondary study design

Non randomised study

Trial setting


Trial type


Patient information sheet

Not available in web format, please use the contact details below to request a patient information sheet.


Respiratory diseases


All participants attend a single study visit, which lasts for approximately four hours. Once a participant is deemed eligible and provides informed consent, participants undergo a range of medical examinations. There is no follow up planned after the study visit.

Angulations of posture are measured using the EOS® system. Six pairs of images will be done, three in sitting position (during calm breathing, after a full inspiration and after a full expiration) , three in standing position in the same conditions. This process takes approximately 30 minutes

Modification of centre of pressure is measured using a force platform on the floor. This involves the application of 78 reflective markers to the whole body, including 35 on the thorax and the abdomen. Motion capture is undertaken using an optoelectronic VICON system. Participants are instructed to perform five different breathing patterns for one minute each in standing position followed by sitting position. This process takes two hours. The breathing patterns are:
1. Quiet breathing with open eyes and mouth
2. Quiet breathing with closed eyes and open mouth
3. Quiet breathing with eyes open and closed mouth
4. Quiet breathing with eyes and mouth closed
5. Quiet breathing for 30 seconds with eyes open, followed by a very short apnea (10-20 seconds) and then deep breathing for 30 seconds

Gait velocity is measured using the stand up and go test. Subject is sitting on a chair and is instructed to stand up, to walk 3 metres, to return and to sit again. Velocity is measured. It takes less than 10 minutes

Lung volume is measured using spirometry. This involves the participants being instructed to blow through a mouth piece as hard as possible (quiet breathing followed by one deep inspiration and one deep expiration).

Intervention type



Drug names

Primary outcome measures

Postural stability is assessed using a force platform and motion capture taken by an optoelectronic VICON system at the study visit

Secondary outcome measures

1. Angulations in posture is measured using the EOS® system at the study visit
2. Gait velocity is measured using the stand up and go test at the study visit
3. Lung volume is measured using spirometry at the study visit

Overall trial start date


Overall trial end date


Reason abandoned


Participant inclusion criteria

1. Healthy participants
2. Aged 18 years and over
3. French nationality

Participant type

Healthy volunteer

Age group




Target number of participants


Participant exclusion criteria

1. Pregnancy (female patients)
2. Known chronic respiratory disease such as asthma, COPD etc.
3. Known chronic postural disease such as scoliosis, etc.
5. Acute infection of respiratory tract
5. Aged under 18 years

Recruitment start date


Recruitment end date



Countries of recruitment


Trial participating centre

Laboratoire de biomécanique humaine Georges charpak Arts et Métiers ParisTech
155 boulevard de l'hôpital

Trial participating centre

Hôpital Pitié-Salpêtrière
47-83 boulevard de l'hôpital

Sponsor information


National Scientific Research Centre (Centre National de la Recherche Scientifique)

Sponsor details

3 Rue Michel Ange
+33 1 44964032

Sponsor type




Funder type


Funder name

National School of Arts and Trades (Ecole Nationale Supérieure d'Arts et Métiers)

Alternative name(s)

Funding Body Type

Funding Body Subtype


Results and Publications

Publication and dissemination plan

Planned publication in a high-impact peer reviewed journal.

IPD Sharing plan:
participant level data will be available upon request to Dr Valérie Attali (

Intention to publish date


Participant level data

Available on request

Results - basic reporting

Publication summary

Publication citations

Additional files

Editorial Notes