Condition category
Mental and Behavioural Disorders
Date applied
Date assigned
Last edited
Prospectively registered
Overall trial status
Recruitment status
No longer recruiting
Publication status

Plain English Summary

Not provided at time of registration

Trial website

Contact information



Primary contact

Prof Stephen Sutton


Contact details

General Practice & Primary Care Research Unit
Department of Public Health & Primary Care
University of Cambridge
Institute of Public Health
Forvie Site
Robinson Way
United Kingdom

Additional identifiers

EudraCT number number

Protocol/serial number


Study information

Scientific title

A randomised controlled trial to assess the feasibility, acceptability and effectiveness of tailored web- and text-based facilitation of smoking cessation in primary care


Study hypothesis

The proposed trial is part of a larger programme of work in the General Practice and Primary Care Research Unit, University of Cambridge, on computer-based approaches to smoking cessation. The intervention to be evaluated in this trial consists of two components:
1. A web-based program designed to be used by a practice nurse or other smoking cessation advisor (SCA); the program generates a cessation advice report that is highly tailored to relevant characteristics of the smoker
2. A three-month program of automatically generated tailored text messages sent to the smoker’s mobile phone

The iQuit program is a potentially cost-effective approach which is designed to enhance the effectiveness of the consultation without requiring nurses to radically change the way they advise and treat smokers and to provide continuing support to smokers during their quit attempts, while reducing the need for them to attend the practice (except for the purpose of obtaining further supplies of nicotine replacement and attending for the routine NHS four-week follow-up appointment).

Ethics approval

Not provided at time of registration

Study design

Two parallel group randomised controlled trial

Primary study design


Secondary study design

Randomised controlled trial

Trial setting


Trial type


Patient information sheet

Not available in web format, please use the contact details below to request a patient information sheet


Smoking cessation


Two groups to be compared:
1. Control group: participants will receive 'usual care' for smoking cessation
2. Intervention group: participants will receive 'usual care' for smoking cessation, plus a printed patient-tailored advice report generated by web-based software, followed by a 90-day program of patient-tailored interactive SMS text messages

Follow up dates:
Routine NHS follow up: 4 weeks from quit date
Research follow up: 8 weeks and 6 months from randomisation date

Intervention type



Not Applicable

Drug names

Primary outcome measure

Self-reported effectiveness, using a self report of being abstinent from smoking for at least 2 weeks, at 8-week follow-up from randomisation date, as assessed by postal questionnaire or telephone interview (blinded interviewer).

Secondary outcome measures

1. Carbon monoxide (CO)-verified self-report of being abstinent from smoking for at least 2 weeks, at 4-week follow-up from quit date
2. Self-reported prolonged abstinence (at least 3 months) at 6-month follow-up from randomisation date

Overall trial start date


Overall trial end date


Reason abandoned (if study stopped)


Participant inclusion criteria

Patients can be included in the study if they meet all of the criteria below:
1. Current smoker (has smoked in the 7 days prior to randomisation date)
2. Able to read English and can provide written informed consent
3. Is seriously considering quitting smoking and is willing to set a quit date within the 14 days after randomisation
4. Aged 18 - 75 years, either sex
5. Has a mobile phone and is familiar with sending and receiving SMS text messages
6. Is willing to participate in study and follow study procedures
7. Is not currently enrolled in another formal smoking cessation study or program
8. Is not using nicotene replacement therapy (NRT), bupropion (Zyban®) and varenicline (Champix®) or other pharmacotherapy at randomisation date

Participant type


Age group




Target number of participants

Total approx 600 (300 in each of the intervention groups)

Participant exclusion criteria

1. Do not meet all of the inclusion criteria
2. Considered by their GP to be unsuitable for the project for any reason e.g. people with severe mental impairment or severely or terminally ill

Co-morbidities, for example chronic obstructive pulmonary disease (COPD), diabetes, are not excluded from the study (unless their GP considers them unsuitable). In addition, we would not exclude entry to the trial of more than one participant per household, however, should this occur, they would be assigned to the same treatment group (to minimise the potential for contamination).

Recruitment start date


Recruitment end date



Countries of recruitment

United Kingdom

Trial participating centre

General Practice & Primary Care Research Unit
United Kingdom

Sponsor information


University of Cambridge (UK)

Sponsor details

Research Services Division
16 Mill Lane
United Kingdom

Sponsor type




Funder type


Funder name

National Institute for Health Research (NIHR) (UK) - School for Primary Care Research (SPCR) (ref: 4.29)

Alternative name(s)

Funding Body Type

Funding Body Subtype


Results and Publications

Publication and dissemination plan

Not provided at time of registration

Intention to publish date

Participant level data

Not provided at time of registration

Basic results (scientific)

Publication list

1. 2013 protocol in
2. 2014 results in

Publication citations

  1. Protocol

    Sutton S, Smith S, Jamison J, Boase S, Mason D, Prevost AT, Brimicombe J, Sloan M, Gilbert H, Naughton F, Study protocol for iQuit in Practice: a randomised controlled trial to assess the feasibility, acceptability and effectiveness of tailored web- and text-based facilitation of smoking cessation in primary care., BMC Public Health, 2013, 13, 324, doi: 10.1186/1471-2458-13-324.

Additional files

Editorial Notes

25/09/2018: Publication reference added.