Contact information
Type
Scientific
Primary contact
Dr Jaclyn Smith
ORCID ID
Contact details
University Hospital of South Manchester NHS Foundation Trust
Wythenshawe Hospital
Southmoor Road
Manchester
M23 9LT
United Kingdom
+44 (0)161 291 5879
jacky.smith@manchester.ac.uk
Additional identifiers
EudraCT number
ClinicalTrials.gov number
Protocol/serial number
N0226187456
Study information
Scientific title
A study to investigate the effects of voluntary coughing on the airways of asthmatic and COPD subjects
Acronym
Study hypothesis
To determine the effects of short bursts of voluntary coughing on airway physiology and lung function in asthmatic and COPD subjects.
Ethics approval
Not provided at time of registration
Study design
Randomised controlled trial
Primary study design
Interventional
Secondary study design
Randomised controlled trial
Trial setting
Hospitals
Trial type
Treatment
Patient information sheet
Not available in web format, please use the contact details below to request a patient information sheet
Condition
Respiratory: Chronic obstructive pulmonary disease (COPD)
Intervention
Subjects will be randomised to either progressively increasing periods of voluntary coughing or no intervention, both interspersed with measurements of lung function.
Intervention type
Other
Phase
Not Specified
Drug names
Primary outcome measures
The fall in exhaled nitric oxide (eNO) following voluntary coughing.
Secondary outcome measures
No secondary outcome measures
Overall trial start date
30/10/2006
Overall trial end date
30/10/2008
Reason abandoned
Eligibility
Participant inclusion criteria
1. Aged over 18
2. Physician diagnosed asthma or COPD
Participant type
Patient
Age group
Adult
Gender
Both
Target number of participants
10 stable mild asthmatic, 10 stable COPD subjects
Participant exclusion criteria
1. Symptoms of upper respiratory tract infection or asthmatic/COPD exacerbation in the preceding 4 weeks
2. Involved in studies with licensed drugs or methodological studies within the preceding 4 weeks
3. Subjects taking ACE inhibitors, leukotrine receptor antagonists or cough suppressants
4. Change in asthma/COPD medication in last 4 weeks
5. Pregnancy
6. Current smokers
Recruitment start date
30/10/2006
Recruitment end date
30/10/2008
Locations
Countries of recruitment
United Kingdom
Trial participating centre
University Hospital of South Manchester NHS Foundation Trust
Manchester
M23 9LT
United Kingdom
Sponsor information
Organisation
Record Provided by the NHSTCT Register - 2007 Update - Department of Health
Sponsor details
The Department of Health
Richmond House
79 Whitehall
London
SW1A 2NL
United Kingdom
+44 (0)207 307 2622
dhmail@doh.gsi.org.uk
Sponsor type
Government
Website
Funders
Funder type
Hospital/treatment centre
Funder name
University Hospital of South Manchester NHS Foundation Trust
Alternative name(s)
Funding Body Type
Funding Body Subtype
Location
Funder name
NWLC Endowment Funds
Alternative name(s)
Funding Body Type
Funding Body Subtype
Location
Funder name
NHS R&D Support Funding
Alternative name(s)
Funding Body Type
Funding Body Subtype
Location
Results and Publications
Publication and dissemination plan
Not provided at time of registration
Intention to publish date
Participant level data
Not provided at time of registration
Results - basic reporting
Publication summary