Contact information
Type
Scientific
Primary contact
Dr Anne Benedicte Juul
ORCID ID
Contact details
Copenhagen Trial Unit
Centre for Clinical Intervention Research
H:S Rigshospitalet
Dept 7102
Copenhagen Ø
DK-2100
Denmark
+45 3545 7156 or +45 3526 7235
Anne.j@ctu.rh.dk
Additional identifiers
EudraCT number
ClinicalTrials.gov number
Protocol/serial number
Not Applicable
Study information
Scientific title
Acronym
DIPOM
Study hypothesis
Not provided at time of registration
Ethics approval
Not provided at time of registration
Study design
Randomised controlled trial
Primary study design
Interventional
Secondary study design
Randomised controlled trial
Trial setting
Hospitals
Trial type
Treatment
Patient information sheet
Condition
Diabetes mellitus and major surgery
Intervention
Diabetic patients undergoing major noncardiac surgery are randomised to 7 days of perioperative beta blocking (Metoprolol CR/XL [SeloZok®] 100 mg daily) versus placebo treatment.
Intervention type
Drug
Phase
Not Specified
Drug names
Metoprolol CR/XL
Primary outcome measure
Not provided at time of registration
Secondary outcome measures
Not provided at time of registration
Overall trial start date
01/07/2000
Overall trial end date
01/07/2002
Reason abandoned (if study stopped)
Eligibility
Participant inclusion criteria
Patients 40 years of age with diabetes undergoing noncardiac major (lasting more than 1 hour) surgery
Participant type
Patient
Age group
Not Specified
Gender
Not Specified
Target number of participants
Not provided at time of registration
Participant exclusion criteria
Not provided at time of registration
Recruitment start date
01/07/2000
Recruitment end date
01/07/2002
Locations
Countries of recruitment
Denmark
Trial participating centre
Copenhagen Trial Unit
Copenhagen Ø
DK-2100
Denmark
Funders
Funder type
Charity
Funder name
The Danish Heart Foundation (Denmark) (ref: 01-2-5-51A-22931)
Alternative name(s)
Funding Body Type
Funding Body Subtype
Location
Funder name
The Danish Diabetes Foundation (Denmark) (ref: C.1)
Alternative name(s)
Funding Body Type
Funding Body Subtype
Location
Funder name
The Copenhagen Hospital Corporation's Research Council (Denmark) (ref: 109/01)
Alternative name(s)
Funding Body Type
Funding Body Subtype
Location
Funder name
Programme for Strengthening Regional Collaboration within Medical Health Research (Denmark) (ref: 301-070-5199)
Alternative name(s)
Funding Body Type
Funding Body Subtype
Location
Funder name
AstraZeneca (Denmark) (ref: AD-MET-0003)
Alternative name(s)
Funding Body Type
private sector organisation
Funding Body Subtype
For-profit companies (industry)
Location
United Kingdom
Results and Publications
Publication and dissemination plan
Not provided at time of registration
Intention to publish date
Participant level data
Not provided at time of registration
Basic results (scientific)
Publication list
Results in http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16793810
Publication citations
-
Results
Juul AB, Wetterslev J, Gluud C, Kofoed-Enevoldsen A, Jensen G, Callesen T, Nørgaard P, Fruergaard K, Bestle M, Vedelsdal R, Miran A, Jacobsen J, Roed J, Mortensen MB, Jørgensen L, Jørgensen J, Rovsing ML, Petersen PL, Pott F, Haas M, Albret R, Nielsen LL, Johansson G, Stjernholm P, Mølgaard Y, Foss NB, Elkjaer J, Dehlie B, Boysen K, Zaric D, Munksgaard A, Madsen JB, Øberg B, Khanykin B, Blemmer T, Yndgaard S, Perko G, Wang LP, Winkel P, Hilden J, Jensen P, Salas N, , Effect of perioperative beta blockade in patients with diabetes undergoing major non-cardiac surgery: randomised placebo controlled, blinded multicentre trial., BMJ, 2006, 332, 7556, 1482, doi: 10.1136/bmj.332.7556.1482.