Efficacy and efficiency of Eye Movement Desensitisation and Reprocessing therapy versus Brief Eclectic Psychotherapy (BEP) in the treatment of post-traumatic stress disorder

ISRCTN ISRCTN64872147
DOI https://doi.org/10.1186/ISRCTN64872147
Secondary identifying numbers NTR46
Submission date
04/08/2005
Registration date
04/08/2005
Last edited
04/09/2015
Recruitment status
No longer recruiting
Overall study status
Completed
Condition category
Mental and Behavioural Disorders
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data

Plain English summary of protocol

Not provided at time of registration

Contact information

Dr M Olff
Scientific

Academic Medical Center (AMC)
Department of Psychiatry
Meibergdreef 5
PA1-192
Amsterdam
1105 AZ
Netherlands

Phone +31 (0)20 891 3662
Email m.olff@amc.uva.nl

Study information

Study designRandomised-controlled parallel-group single-blinded trial
Primary study designInterventional
Secondary study designRandomised controlled trial
Study setting(s)Not specified
Study typeTreatment
Participant information sheet Not available in web format, please use the contact details below to request a patient information sheet
Scientific titleEfficacy and efficiency of Eye Movement Desensitisation and Reprocessing therapy versus Brief Eclectic Psychotherapy (BEP) in the treatment of post-traumatic stress disorder
Study acronymBEP-EMDR
Study objectivesEye movement desensitisation and reprocessing (EMDR) therapy is applied frequently in clinical practice as a treatment method for psychological trauma. Arguments for applying EMDR are faster symptom reduction, lower dropout and better tolerance than cognitive behavioural interventions. However, in the Netherlands a randomised controlled study determining efficacy and efficiency of EMDR has not yet been performed.

Research objectives:
1. To compare efficacy of EMDR therapy and brief eclectic psychotherapy (BEP) in the treatment of patients with post-traumatic stress disorder
2. To test whether EMDR is more efficient than BEP
3. To determine efficacy of the treatments at long-term follow up
4. To determine which patients benefit most from EMDR or BEP
5. To determine the effects of both treatments on comorbid psychopathology, like major depressive disorder

The overall trial end date was changed from 01/12/2006 to 01/12/2007.

On 14/02/2012 the following changes were made to the trial record:
1. The target number of participants was changed from 120 to 140.
2. The overall trial end date was changed from 01/12/2007 to 01/02/2009.
Ethics approval(s)Ethics approval received from the local ethics committee
Health condition(s) or problem(s) studiedMental disorders, post-traumatic stress disorder
InterventionEMDR is a combination of trauma exposure (desensitisation) with saccadic eye movements. When anxiety diminishes, the patient is instructed to develop more positive cognitions and link these to the trauma.

BEP is primarily a cognitive behavioral intervention, but 'eclectic' means that elements of psychodynamic and directive psychotherapy are also part of this therapy.
Intervention typeOther
Primary outcome measure1. Impact of Event Scale - Revised (IES-R)
2. Hospital Anxiety and Depression Scale (HADS)
Secondary outcome measuresStructured clinical interviews are administered, as well as neuropsychological tests and other self-report measures.
Overall study start date01/12/2003
Completion date01/02/2009

Eligibility

Participant type(s)Patient
Age groupAdult
SexBoth
Target number of participants140
Key inclusion criteriaCurrent inclusion criteria as of 14/02/2012
One hundred and forty patients with post-traumatic stress disorder for at least one month after the traumatic experience according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria, will be included. They are asked to participate after intake at the Outpatient Psychiatry Clinic of the Academic Medical Center/De Meren.

Previous inclusion criteria
One hundred and twenty patients with post-traumatic stress disorder for at least one month after the traumatic experience according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria, will be included. They are asked to participate after intake at the Outpatient Psychiatry Clinic of the Academic Medical Center/De Meren.
Key exclusion criteria1. Severe comorbidity that would interfere with treatment
2. Enhanced risk for suicide and psychotic disorders
Date of first enrolment01/12/2003
Date of final enrolment01/02/2009

Locations

Countries of recruitment

  • Netherlands

Study participating centre

Academic Medical Center (AMC)
Amsterdam
1105 AZ
Netherlands

Sponsor information

Academic Medical Centre (AMC) (The Netherlands)
University/education

Emma Kinderziekenhuis
P.O.Box 22660
Amsterdam
1105 AZ
Netherlands

Website http://www.amc.uva.nl/
ROR logo "ROR" https://ror.org/03t4gr691

Funders

Funder type

Hospital/treatment centre

Academisch Medisch Centrum
Private sector organisation / Universities (academic only)
Alternative name(s)
Academic Medical Center, AMC
Location
Netherlands

Results and Publications

Intention to publish date
Individual participant data (IPD) Intention to shareNo
IPD sharing plan summaryNot provided at time of registration
Publication and dissemination planNot provided at time of registration
IPD sharing plan

Study outputs

Output type Details Date created Date added Peer reviewed? Patient-facing?
Results article results 01/03/2012 Yes No
Results article results 01/08/2015 Yes No