The N-methyl-D-aspartate (NMDA)-antagonist memantine affects training induced motor cortex plasticity: a study using transcranial magnetic stimulation
| ISRCTN | ISRCTN65784760 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN65784760 |
| Secondary identifying numbers | N/A |
- Submission date
- 06/05/2005
- Registration date
- 09/05/2005
- Last edited
- 15/02/2008
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Other
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Plain English summary of protocol
Not provided at time of registration
Contact information
Prof Martin Tegenthoff
Scientific
Scientific
Department of Neurology
BG-Kliniken Bergmannsheil
Buerkle-de-la-Camp-Platz 1
Bochum
44789
Germany
Study information
| Study design | Randomised controlled trial |
|---|---|
| Primary study design | Interventional |
| Secondary study design | Randomised controlled trial |
| Study setting(s) | Hospital |
| Study type | Treatment |
| Scientific title | |
| Study objectives | Training of a repetitive synchronised movement of two limb muscles leads to short-term plastic changes in the primary motor cortex, which can be assessed by transcranial magnetic stimulation (TMS) mapping. |
| Ethics approval(s) | Not provided at time of registration |
| Health condition(s) or problem(s) studied | Training induced motor cortex plasticity |
| Intervention | Memantine versus placebo either given as a single dose or daily over 8 days. |
| Intervention type | Drug |
| Pharmaceutical study type(s) | |
| Phase | Not Specified |
| Drug / device / biological / vaccine name(s) | Memantine |
| Primary outcome measure | The differential effects of different treatment regimens. |
| Secondary outcome measures | Not provided at time of registration |
| Overall study start date | 01/06/1998 |
| Completion date | 31/01/2005 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Adult |
| Sex | Both |
| Target number of participants | 20 |
| Key inclusion criteria | Healthy subjects (adults, either sex) |
| Key exclusion criteria | 1. Left-handedness 2. Neurological disorders 3. Intake of central acting drugs |
| Date of first enrolment | 01/06/1998 |
| Date of final enrolment | 31/01/2005 |
Locations
Countries of recruitment
- Germany
Study participating centre
Department of Neurology
Bochum
44789
Germany
44789
Germany
Sponsor information
BG-Kliniken Bergmannsheil (Germany) - Department of Neurology
Hospital/treatment centre
Hospital/treatment centre
Buerkle-de-la-Camp-Platz 1
Bochum
44789
Germany
"ROR" |
https://ror.org/04j9bvy88 |
|---|
Funders
Funder type
Hospital/treatment centre
BG-Kliniken Bergmannsheil (Germany) - Department of Neurology; main funders
No information available
Merz Pharmaceuticals GmbH (Germany) - funded the measurement of the memantine serum levels
No information available
Results and Publications
| Intention to publish date | |
|---|---|
| Individual participant data (IPD) Intention to share | No |
| IPD sharing plan summary | Not provided at time of registration |
| Publication and dissemination plan | Not provided at time of registration |
| IPD sharing plan |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Results article | Results | 12/05/2005 | Yes | No |
