Additional identifiers
EudraCT number
ClinicalTrials.gov number
Protocol/serial number
N/A
Study information
Scientific title
Acronym
Study hypothesis
Training of a repetitive synchronised movement of two limb muscles leads to short-term plastic changes in the primary motor cortex, which can be assessed by transcranial magnetic stimulation (TMS) mapping.
Ethics approval
Not provided at time of registration
Study design
Randomised controlled trial
Primary study design
Interventional
Secondary study design
Randomised controlled trial
Trial setting
Hospitals
Trial type
Treatment
Patient information sheet
Condition
Training induced motor cortex plasticity
Intervention
Memantine versus placebo either given as a single dose or daily over 8 days.
Intervention type
Drug
Phase
Not Specified
Drug names
Memantine
Primary outcome measure
The differential effects of different treatment regimens.
Secondary outcome measures
Not provided at time of registration
Overall trial start date
01/06/1998
Overall trial end date
31/01/2005
Reason abandoned (if study stopped)
Eligibility
Participant inclusion criteria
Healthy subjects (adults, either sex)
Participant type
Patient
Age group
Adult
Gender
Both
Target number of participants
20
Participant exclusion criteria
1. Left-handedness
2. Neurological disorders
3. Intake of central acting drugs
Recruitment start date
01/06/1998
Recruitment end date
31/01/2005
Locations
Countries of recruitment
Germany
Trial participating centre
Department of Neurology
Bochum
44789
Germany
Funders
Funder type
Hospital/treatment centre
Funder name
BG-Kliniken Bergmannsheil (Germany) - Department of Neurology; main funders
Alternative name(s)
Funding Body Type
Funding Body Subtype
Location
Funder name
Merz Pharmaceuticals GmbH (Germany) - funded the measurement of the memantine serum levels
Alternative name(s)
Funding Body Type
Funding Body Subtype
Location
Results and Publications
Publication and dissemination plan
Not provided at time of registration
Intention to publish date
Participant level data
Not provided at time of registration
Basic results (scientific)
Publication list
Results in http://www.ncbi.nlm.nih.gov/pubmed/15890074
Publication citations
-
Results
Schwenkreis P, Witscher K, Pleger B, Malin JP, Tegenthoff M, The NMDA antagonist memantine affects training induced motor cortex plasticity--a study using transcranial magnetic stimulation., BMC Neurosci, 2005, 6, 35, doi: 10.1186/1471-2202-6-35.