Condition category
Not Applicable
Date applied
06/05/2005
Date assigned
09/05/2005
Last edited
15/02/2008
Prospective/Retrospective
Retrospectively registered
Overall trial status
Completed
Recruitment status
No longer recruiting

Plain English Summary

Not provided at time of registration

Trial website

Contact information

Type

Scientific

Primary contact

Prof Martin Tegenthoff

ORCID ID

Contact details

Department of Neurology
BG-Kliniken Bergmannsheil
Buerkle-de-la-Camp-Platz 1
Bochum
44789
Germany

Additional identifiers

EudraCT number

ClinicalTrials.gov number

Protocol/serial number

N/A

Study information

Scientific title

Acronym

Study hypothesis

Training of a repetitive synchronised movement of two limb muscles leads to short-term plastic changes in the primary motor cortex, which can be assessed by transcranial magnetic stimulation (TMS) mapping.

Ethics approval

Not provided at time of registration

Study design

Randomised controlled trial

Primary study design

Interventional

Secondary study design

Randomised controlled trial

Trial setting

Hospitals

Trial type

Treatment

Patient information sheet

Condition

Training induced motor cortex plasticity

Intervention

Memantine versus placebo either given as a single dose or daily over 8 days.

Intervention type

Drug

Phase

Not Specified

Drug names

Memantine

Primary outcome measures

The differential effects of different treatment regimens.

Secondary outcome measures

Not provided at time of registration

Overall trial start date

01/06/1998

Overall trial end date

31/01/2005

Reason abandoned

Eligibility

Participant inclusion criteria

Healthy subjects (adults, either sex)

Participant type

Patient

Age group

Adult

Gender

Both

Target number of participants

20

Participant exclusion criteria

1. Left-handedness
2. Neurological disorders
3. Intake of central acting drugs

Recruitment start date

01/06/1998

Recruitment end date

31/01/2005

Locations

Countries of recruitment

Germany

Trial participating centre

Department of Neurology
Bochum
44789
Germany

Sponsor information

Organisation

BG-Kliniken Bergmannsheil (Germany) - Department of Neurology

Sponsor details

Buerkle-de-la-Camp-Platz 1
Bochum
44789
Germany

Sponsor type

Hospital/treatment centre

Website

Funders

Funder type

Hospital/treatment centre

Funder name

BG-Kliniken Bergmannsheil (Germany) - Department of Neurology; main funders

Alternative name(s)

Funding Body Type

Funding Body Subtype

Location

Funder name

Merz Pharmaceuticals GmbH (Germany) - funded the measurement of the memantine serum levels

Alternative name(s)

Funding Body Type

Funding Body Subtype

Location

Results and Publications

Publication and dissemination plan

Not provided at time of registration

Intention to publish date

Participant level data

Not provided at time of registration

Results - basic reporting

Publication summary

Results in http://www.ncbi.nlm.nih.gov/pubmed/15890074

Publication citations

  1. Results

    Schwenkreis P, Witscher K, Pleger B, Malin JP, Tegenthoff M, The NMDA antagonist memantine affects training induced motor cortex plasticity--a study using transcranial magnetic stimulation., BMC Neurosci, 2005, 6, 35, doi: 10.1186/1471-2202-6-35.

Additional files

Editorial Notes