The Use of Proton Pump Inhibitors in General Practice

ISRCTN	ISRCTN70358598
DOI	https://doi.org/10.1186/ISRCTN70358598
Secondary identifying numbers	RRCC704F R340166

Submission date: 23/01/2004
Registration date: 23/01/2004
Last edited: 15/08/2011

Recruitment status: No longer recruiting
Overall study status: Completed
Condition category: Digestive System

Prospectively registered

Protocol

Statistical analysis plan

Results

Individual participant data

Plain English summary of protocol

Not provided at time of registration

Contact information

Dr A Raghunath
Scientific

Marmaduke Health Centre
Hessle Road
Hull
HU3 3BH
United Kingdom

Phone	+44 (0)1482 327 708

Study information

Study design	Randomised controlled trial
Primary study design	Interventional
Secondary study design	Randomised controlled trial
Study setting(s)	Not specified
Study type	Not Specified
Scientific title
Study objectives	The aim of this study is three fold: to improve our understanding of the prescribing behaviour of GPs with regard to PPIs; to better understand the perceived benefits by patients and; to test the feasibility of an exercise designed to reduce their consumption. Objectives: 1. To ascertain the knowledge and attitudes of GPs and variations between GPs in prescribing PPIs, both when initiating therapy and for long-term maintenance. 2. To ascertain from patients on repeat PPI prescriptions the perceived benefits of treatment with PPIs, including symptom control and wider social benefits e.g. on lifestyle. 3. To devise and pilot for feasibility, and for evaluating sustainability, a strategy for switching a sample of patients on long term therapy to lower strengths of PPIs, with a view to advising a larger scale intervention study.
Ethics approval(s)	Not provided at time of registration
Health condition(s) or problem(s) studied	Digestive system diseases: Peptic ulcer disease
Intervention	Not provided at time of registration
Intervention type	Drug
Pharmaceutical study type(s)
Phase	Not Specified
Drug / device / biological / vaccine name(s)	Proton Pump Inhibitors
Primary outcome measure	1. Better understanding of the prescribing behaviour of PPIs by General Practitioners. 2. Better understanding of the patients perceived benefits of using long-term PPIs. 3. Success of feasibility, concordance, need for rescue therapy and sustainability of switch to lower dose PPIs.
Secondary outcome measures	Not provided at time of registration
Overall study start date	10/01/1999
Completion date	04/01/2002

Eligibility

Participant type(s)	Patient
Age group	Not Specified
Sex	Not Specified
Target number of participants	Not provided at time of registration
Key inclusion criteria	Not provided at time of registration
Key exclusion criteria	Not provided at time of registration
Date of first enrolment	10/01/1999
Date of final enrolment	04/01/2002

Locations

Countries of recruitment

England
United Kingdom

Study participating centre

Marmaduke Health Centre

Hull
HU3 3BH
United Kingdom

Sponsor information

NHS R&D Regional Programme Register - Department of Health (UK)
Government

The Department of Health
Richmond House
79 Whitehall
London
SW1A 2NL
United Kingdom

Phone	+44 (0)20 7307 2622
Email	dhmail@doh.gsi.org.uk
Website	http://www.doh.gov.uk

Funders

Funder type

Government

NHS Executive Northern and Yorkshire (UK)

No information available

Results and Publications

Intention to publish date
Individual participant data (IPD) Intention to share	No
IPD sharing plan summary	Not provided at time of registration
Publication and dissemination plan	Not provided at time of registration
IPD sharing plan

Study outputs

Output type	Details	Date created	Date added	Peer reviewed?	Patient-facing?
Results article	results	01/06/2005		Yes	No