Condition category
Digestive System
Date applied
23/01/2004
Date assigned
23/01/2004
Last edited
15/08/2011
Prospective/Retrospective
Retrospectively registered
Overall trial status
Completed
Recruitment status
No longer recruiting

Plain English Summary

Not provided at time of registration

Trial website

Contact information

Type

Scientific

Primary contact

Dr A Raghunath

ORCID ID

Contact details

Marmaduke Health Centre
Hessle Road
Hull
HU3 3BH
United Kingdom
+44 (0)1482 327 708

Additional identifiers

EudraCT number

ClinicalTrials.gov number

Protocol/serial number

RRCC704F R340166

Study information

Scientific title

Acronym

Study hypothesis

The aim of this study is three fold: to improve our understanding of the prescribing behaviour of GPs with regard to PPIs; to better understand the perceived benefits by patients and; to test the feasibility of an exercise designed to reduce their consumption. Objectives:
1. To ascertain the knowledge and attitudes of GPs and variations between GPs in prescribing PPIs, both when initiating therapy and for long-term maintenance.
2. To ascertain from patients on repeat PPI prescriptions the perceived benefits of treatment with PPIs, including symptom control and wider social benefits e.g. on lifestyle.
3. To devise and pilot for feasibility, and for evaluating sustainability, a strategy for switching a sample of patients on long term therapy to lower strengths of PPIs, with a view to advising a larger scale intervention study.

Ethics approval

Not provided at time of registration

Study design

Randomised controlled trial

Primary study design

Interventional

Secondary study design

Randomised controlled trial

Trial setting

Not specified

Trial type

Not Specified

Patient information sheet

Condition

Digestive system diseases: Peptic ulcer disease

Intervention

Not provided at time of registration

Intervention type

Drug

Phase

Not Specified

Drug names

Proton Pump Inhibitors

Primary outcome measures

1. Better understanding of the prescribing behaviour of PPIs by General Practitioners.
2. Better understanding of the patients perceived benefits of using long-term PPIs.
3. Success of feasibility, concordance, need for rescue therapy and sustainability of switch to lower dose PPIs.

Secondary outcome measures

Not provided at time of registration

Overall trial start date

10/01/1999

Overall trial end date

04/01/2002

Reason abandoned

Eligibility

Participant inclusion criteria

Not provided at time of registration

Participant type

Patient

Age group

Not Specified

Gender

Not Specified

Target number of participants

Not provided at time of registration

Participant exclusion criteria

Not provided at time of registration

Recruitment start date

10/01/1999

Recruitment end date

04/01/2002

Locations

Countries of recruitment

United Kingdom

Trial participating centre

Marmaduke Health Centre
Hull
HU3 3BH
United Kingdom

Sponsor information

Organisation

NHS R&D Regional Programme Register - Department of Health (UK)

Sponsor details

The Department of Health
Richmond House
79 Whitehall
London
SW1A 2NL
United Kingdom
+44 (0)20 7307 2622
dhmail@doh.gsi.org.uk

Sponsor type

Government

Website

http://www.doh.gov.uk

Funders

Funder type

Government

Funder name

NHS Executive Northern and Yorkshire (UK)

Alternative name(s)

Funding Body Type

Funding Body Subtype

Location

Results and Publications

Publication and dissemination plan

Not provided at time of registration

Intention to publish date

Participant level data

Not provided at time of registration

Results - basic reporting

Publication summary

1. 2005 results in http://www.ncbi.nlm.nih.gov/pubmed/16286734

Publication citations

  1. Results

    Raghunath AS, Hungin AP, Cornford CS, Featherstone V, Use of proton pump inhibitors: an exploration of the attitudes, knowledge and perceptions of general practitioners., Digestion, 2005, 72, 4, 212-218, doi: 10.1159/000089727.

Additional files

Editorial Notes