Additional identifiers
EudraCT number
ClinicalTrials.gov number
Protocol/serial number
RRCC704F R340166
Study information
Scientific title
Acronym
Study hypothesis
The aim of this study is three fold: to improve our understanding of the prescribing behaviour of GPs with regard to PPIs; to better understand the perceived benefits by patients and; to test the feasibility of an exercise designed to reduce their consumption. Objectives:
1. To ascertain the knowledge and attitudes of GPs and variations between GPs in prescribing PPIs, both when initiating therapy and for long-term maintenance.
2. To ascertain from patients on repeat PPI prescriptions the perceived benefits of treatment with PPIs, including symptom control and wider social benefits e.g. on lifestyle.
3. To devise and pilot for feasibility, and for evaluating sustainability, a strategy for switching a sample of patients on long term therapy to lower strengths of PPIs, with a view to advising a larger scale intervention study.
Ethics approval
Not provided at time of registration
Study design
Randomised controlled trial
Primary study design
Interventional
Secondary study design
Randomised controlled trial
Trial setting
Not specified
Trial type
Not Specified
Patient information sheet
Condition
Digestive system diseases: Peptic ulcer disease
Intervention
Not provided at time of registration
Intervention type
Drug
Phase
Not Specified
Drug names
Proton Pump Inhibitors
Primary outcome measure
1. Better understanding of the prescribing behaviour of PPIs by General Practitioners.
2. Better understanding of the patients perceived benefits of using long-term PPIs.
3. Success of feasibility, concordance, need for rescue therapy and sustainability of switch to lower dose PPIs.
Secondary outcome measures
Not provided at time of registration
Overall trial start date
10/01/1999
Overall trial end date
04/01/2002
Reason abandoned (if study stopped)
Eligibility
Participant inclusion criteria
Not provided at time of registration
Participant type
Patient
Age group
Not Specified
Gender
Not Specified
Target number of participants
Not provided at time of registration
Participant exclusion criteria
Not provided at time of registration
Recruitment start date
10/01/1999
Recruitment end date
04/01/2002
Locations
Countries of recruitment
United Kingdom
Trial participating centre
Marmaduke Health Centre
Hull
HU3 3BH
United Kingdom
Sponsor information
Organisation
NHS R&D Regional Programme Register - Department of Health (UK)
Sponsor details
The Department of Health
Richmond House
79 Whitehall
London
SW1A 2NL
United Kingdom
+44 (0)20 7307 2622
dhmail@doh.gsi.org.uk
Sponsor type
Government
Website
Funders
Funder type
Government
Funder name
NHS Executive Northern and Yorkshire (UK)
Alternative name(s)
Funding Body Type
Funding Body Subtype
Location
Results and Publications
Publication and dissemination plan
Not provided at time of registration
Intention to publish date
Participant level data
Not provided at time of registration
Basic results (scientific)
Publication list
1. 2005 results in http://www.ncbi.nlm.nih.gov/pubmed/16286734
Publication citations
-
Results
Raghunath AS, Hungin AP, Cornford CS, Featherstone V, Use of proton pump inhibitors: an exploration of the attitudes, knowledge and perceptions of general practitioners., Digestion, 2005, 72, 4, 212-218, doi: 10.1159/000089727.