Condition category
Circulatory System
Date applied
07/09/2005
Date assigned
08/09/2005
Last edited
19/05/2011
Prospective/Retrospective
Retrospectively registered
Overall trial status
Completed
Recruitment status
No longer recruiting

Plain English Summary

Not provided at time of registration

Trial website

Contact information

Type

Scientific

Primary contact

Prof Tom Meade

ORCID ID

Contact details

Non-communicable Disease Epidemiology Unit
London School of Hygiene and Tropical Medicine
Keppel Street
London
WC1E 7HT
United Kingdom
tom.meade@lshtm.ac.uk

Additional identifiers

EudraCT number

ClinicalTrials.gov number

Protocol/serial number

N/A

Study information

Scientific title

Acronym

Study hypothesis

Lowering mild to moderate hypertension leads to a reduction in rates of stroke, deaths due to hypertension and of coronary events in men and women aged 35-64 years.

Ethics approval

Not provided at time of registration.

Study design

Randomised controlled trial

Primary study design

Interventional

Secondary study design

Randomised controlled trial

Trial setting

Not specified

Trial type

Treatment

Patient information sheet

Condition

Hypertension

Intervention

Bendrofluazide or propranolol compared with placebo.

Intervention type

Drug

Phase

Not Specified

Drug names

Bendrofluazide and propranolol

Primary outcome measures

Stroke, deaths due to hypertension and of coronary events.

Secondary outcome measures

Not provided at time of registration

Overall trial start date

01/01/1973

Overall trial end date

01/12/1982

Reason abandoned

Eligibility

Participant inclusion criteria

Men and women age 35-64 at recruitment in 176 general practices in the Medical Research Council's General Practice Research Framework. Diastolic blood pressure of 90-109 mmHg with a systolic pressure below 200 mmHg.

Participant type

Patient

Age group

Adult

Gender

Both

Target number of participants

18,000 participants

Participant exclusion criteria

Secondary hypertension; already on antihypertensive treatment; accepted indication for antihypertensive treatment; myocardial infarction or stroke within previous three months; presence of angina, intermittent claudication, diabetes, gout, bronchial asthma, serious intercurrent disease, pregnancy.

Recruitment start date

01/01/1973

Recruitment end date

01/12/1982

Locations

Countries of recruitment

United Kingdom

Trial participating centre

Non-communicable Disease Epidemiology Unit
London
WC1E 7HT
United Kingdom

Sponsor information

Organisation

Sponsor not defined - Record provided by the Medical Research Council (UK)

Sponsor details

20 Park Crescent
London
W1B 1AL
United Kingdom
tom.meade@lshtm.ac.uk

Sponsor type

Not defined

Website

Funders

Funder type

Research council

Funder name

Medical Research Council (UK)

Alternative name(s)

MRC

Funding Body Type

private sector organisation

Funding Body Subtype

other non-profit

Location

United Kingdom

Results and Publications

Publication and dissemination plan

Not provided at time of registration

Intention to publish date

Participant level data

Not provided at time of registration

Results - basic reporting

Publication summary

1992 results in http://www.ncbi.nlm.nih.gov/pubmed/1445513

Publication citations

  1. Results

    Medical Research Council trial of treatment of hypertension in older adults: principal results. MRC Working Party., BMJ, 1992, 304, 6824, 405-412.

Additional files

Editorial Notes