Medical Research Council trial of treatment of mild hypertension

ISRCTN ISRCTN72268178
DOI https://doi.org/10.1186/ISRCTN72268178
Secondary identifying numbers N/A
Submission date
07/09/2005
Registration date
08/09/2005
Last edited
19/05/2011
Recruitment status
No longer recruiting
Overall study status
Completed
Condition category
Circulatory System
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data

Plain English summary of protocol

Not provided at time of registration

Contact information

Prof Tom Meade
Scientific

Non-communicable Disease Epidemiology Unit
London School of Hygiene and Tropical Medicine
Keppel Street
London
WC1E 7HT
United Kingdom

Email tom.meade@lshtm.ac.uk

Study information

Study designRandomised controlled trial
Primary study designInterventional
Secondary study designRandomised controlled trial
Study setting(s)Not specified
Study typeTreatment
Scientific title
Study objectivesLowering mild to moderate hypertension leads to a reduction in rates of stroke, deaths due to hypertension and of coronary events in men and women aged 35-64 years.
Ethics approval(s)Not provided at time of registration.
Health condition(s) or problem(s) studiedHypertension
InterventionBendrofluazide or propranolol compared with placebo.
Intervention typeDrug
Pharmaceutical study type(s)
PhaseNot Specified
Drug / device / biological / vaccine name(s)Bendrofluazide and propranolol
Primary outcome measureStroke, deaths due to hypertension and of coronary events.
Secondary outcome measuresNot provided at time of registration
Overall study start date01/01/1973
Completion date01/12/1982

Eligibility

Participant type(s)Patient
Age groupAdult
SexBoth
Target number of participants18,000 participants
Key inclusion criteriaMen and women age 35-64 at recruitment in 176 general practices in the Medical Research Council's General Practice Research Framework. Diastolic blood pressure of 90-109 mmHg with a systolic pressure below 200 mmHg.
Key exclusion criteriaSecondary hypertension; already on antihypertensive treatment; accepted indication for antihypertensive treatment; myocardial infarction or stroke within previous three months; presence of angina, intermittent claudication, diabetes, gout, bronchial asthma, serious intercurrent disease, pregnancy.
Date of first enrolment01/01/1973
Date of final enrolment01/12/1982

Locations

Countries of recruitment

  • England
  • United Kingdom

Study participating centre

Non-communicable Disease Epidemiology Unit
London
WC1E 7HT
United Kingdom

Sponsor information

Sponsor not defined - Record provided by the Medical Research Council (UK)
Not defined

20 Park Crescent
London
W1B 1AL
United Kingdom

Email tom.meade@lshtm.ac.uk

Funders

Funder type

Research council

Medical Research Council (UK)
Government organisation / National government
Alternative name(s)
Medical Research Council (United Kingdom), UK Medical Research Council, MRC
Location
United Kingdom

Results and Publications

Intention to publish date
Individual participant data (IPD) Intention to shareNo
IPD sharing plan summaryNot provided at time of registration
Publication and dissemination planNot provided at time of registration
IPD sharing plan

Study outputs

Output type Details Date created Date added Peer reviewed? Patient-facing?
Results article results 15/02/1992 Yes No