Contact information
Type
Scientific
Primary contact
Prof Tom Meade
ORCID ID
Contact details
Non-communicable Disease Epidemiology Unit
London School of Hygiene and Tropical Medicine
Keppel Street
London
WC1E 7HT
United Kingdom
tom.meade@lshtm.ac.uk
Additional identifiers
EudraCT number
ClinicalTrials.gov number
Protocol/serial number
N/A
Study information
Scientific title
Acronym
Study hypothesis
Lowering mild to moderate hypertension leads to a reduction in rates of stroke, deaths due to hypertension and of coronary events in men and women aged 35-64 years.
Ethics approval
Not provided at time of registration.
Study design
Randomised controlled trial
Primary study design
Interventional
Secondary study design
Randomised controlled trial
Trial setting
Not specified
Trial type
Treatment
Patient information sheet
Condition
Hypertension
Intervention
Bendrofluazide or propranolol compared with placebo.
Intervention type
Drug
Phase
Not Specified
Drug names
Bendrofluazide and propranolol
Primary outcome measures
Stroke, deaths due to hypertension and of coronary events.
Secondary outcome measures
Not provided at time of registration
Overall trial start date
01/01/1973
Overall trial end date
01/12/1982
Reason abandoned
Eligibility
Participant inclusion criteria
Men and women age 35-64 at recruitment in 176 general practices in the Medical Research Council's General Practice Research Framework. Diastolic blood pressure of 90-109 mmHg with a systolic pressure below 200 mmHg.
Participant type
Patient
Age group
Adult
Gender
Both
Target number of participants
18,000 participants
Participant exclusion criteria
Secondary hypertension; already on antihypertensive treatment; accepted indication for antihypertensive treatment; myocardial infarction or stroke within previous three months; presence of angina, intermittent claudication, diabetes, gout, bronchial asthma, serious intercurrent disease, pregnancy.
Recruitment start date
01/01/1973
Recruitment end date
01/12/1982
Locations
Countries of recruitment
United Kingdom
Trial participating centre
Non-communicable Disease Epidemiology Unit
London
WC1E 7HT
United Kingdom
Sponsor information
Organisation
Sponsor not defined - Record provided by the Medical Research Council (UK)
Sponsor details
20 Park Crescent
London
W1B 1AL
United Kingdom
tom.meade@lshtm.ac.uk
Sponsor type
Not defined
Website
Funders
Funder type
Research council
Funder name
Medical Research Council (UK)
Alternative name(s)
MRC
Funding Body Type
government organisation
Funding Body Subtype
Federal/National Government
Location
United Kingdom
Results and Publications
Publication and dissemination plan
Not provided at time of registration
Intention to publish date
Participant level data
Not provided at time of registration
Results - basic reporting
Publication summary
1992 results in http://www.ncbi.nlm.nih.gov/pubmed/1445513
Publication citations
-
Results
Medical Research Council trial of treatment of hypertension in older adults: principal results. MRC Working Party., BMJ, 1992, 304, 6824, 405-412.