Comparison of DWI-MRI and 18F-FDG PET/CT whole body scans in the diagnosis of tumors
| ISRCTN | ISRCTN72560777 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN72560777 |
| Secondary identifying numbers | 2012-08-DWI; 2012-08-FDG |
- Submission date
- 21/08/2012
- Registration date
- 05/09/2012
- Last edited
- 30/03/2017
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Cancer
Plain English summary of protocol
Background and study aims:
There are different types of medical scans that can be used to diagnose tumours (a mass of cells). Diffusion weighted imaging- magnetic resonance imaging (DWI-MRI) is a type of scan that uses the changes of water movement to create an image. 18F-fluorodeoxyglucose Positron Emission Tomography (18F-FDG PET) is a type of scan that uses a small amount of a drug as a tracer (FDG) to show the difference between healthy tissue and diseased tissue. These two different scans show tumour in different ways. Some researchers think DWI-MRI scans can replace 18F-FDG PET scans for diagnosing tumours and that 18F-FDG PET should only be used for certain types of cancers. The aim of this study is to compare different types of imaging to see which one has the best clinical outcomes for diagnosing tumours.
Who can participate?
Adults aged 18-80 who have brain, lung, liver and pancreatic tumour.
What does the study involve?
Participants undergo their standard scan using the 18F-FDG PET/CT scan or the DWI-MRI. Each scan is assessed to see how well it can diagnose tumours.
What are the possible benefits and risks of participating?
There are no notable benefits or risks with participating.
Where is the study run from?
Fourth Military Medical University (China)
When is study starting and how long is it expected to run for?
August 2012 to March 2013
Who is funding the study?
Xijing Hospital (China)
Who is the main contact?
Prof Jing Wang
wangjing@fmmu.edu.cn
Contact information
Scientific
Fourth Military Medical University
127 West Changle Road
Xi'an
710032
China
Study information
| Study design | Prospective randomized blinded controlled study |
|---|---|
| Primary study design | Interventional |
| Secondary study design | Randomised controlled trial |
| Study setting(s) | Hospital |
| Study type | Diagnostic |
| Participant information sheet | Not available in web format, please use the contact details below to request a patient information sheet |
| Scientific title | Comparison of the efficacy of DWI-MRI and 18F-FDG PET/CT whole body scans in the diagnosis of tumors: a multicenter clinical study |
| Study objectives | DWI (Diffusion weighted imaging, WI) and 18F-FDG PET/CT different imaging mechanism, comparison of DWI-MRI and 18F-FDG PET/CT whole body scan in the diagnosis of tumor efficacy and to find out the best clinical indications. Choice in different city 9 PET/CT center participated in the study. |
| Ethics approval(s) | Not provided at time of regsitration |
| Health condition(s) or problem(s) studied | Brain, lung, liver and pancreatic tumor including T, N and M staging. |
| Intervention | Injection FDG accoring to mCi/KG. The research focus is to find DWI-MR and FDG PET/CT, as well as how to play their respective advantages in clinical. |
| Intervention type | Other |
| Primary outcome measure | 1. 18F-FDG PET/CT: the number of lesion, SUV 2. DWI-MRI: the number of lesion, ADC |
| Secondary outcome measures | 1. 18F-FDG PET/CT: tumor volume, TLG (suv evolume) 2. DWI-MRI: tumor volume and size (max long axial) |
| Overall study start date | 30/08/2012 |
| Completion date | 30/03/2013 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Adult |
| Lower age limit | 18 Years |
| Upper age limit | 80 Years |
| Sex | Both |
| Target number of participants | More than 150 cases |
| Key inclusion criteria | Brain, lung, liver and pancreatic tumor including T, N and M staging. 1. Age of 18 - 80 years 2. Clinical pathology in patients with brain, lung, liver and pancreaticcancer 3. Patients without radiotherapy, chemotherapy 4. DWI and 18F-FDG PET/CT scanning in the same week 5. DWI and 18F-FDG PET/CT scanning sequence is random 6. Volunteered to participate in and signed informed consent |
| Key exclusion criteria | 1. Withdrawal of informed consent 2. Without pathology result 3. Against research programme |
| Date of first enrolment | 30/08/2012 |
| Date of final enrolment | 30/03/2013 |
Locations
Countries of recruitment
- China
Study participating centre
710032
China
Sponsor information
University/education
c/o Prof Jing Wang
127 West Changle Road
Xian
710032
China
| Website | http://www.xjhyx.com/ |
|---|---|
"ROR" |
https://ror.org/00ms48f15 |
Funders
Funder type
Hospital/treatment centre
No information available
Results and Publications
| Intention to publish date | |
|---|---|
| Individual participant data (IPD) Intention to share | No |
| IPD sharing plan summary | Not provided at time of registration |
| Publication and dissemination plan | Not provided at time of registration |
| IPD sharing plan |
Editorial Notes
30/03/2017: Plain English summary added.
