Condition category
Infections and Infestations
Date applied
07/11/2005
Date assigned
10/01/2006
Last edited
18/04/2008
Prospective/Retrospective
Retrospectively registered
Overall trial status
Completed
Recruitment status
No longer recruiting

Plain English Summary

Not provided at time of registration

Trial website

Contact information

Type

Scientific

Primary contact

Prof Gary French

ORCID ID

Contact details

Department of Infection
5th Floor North Wing
St.Thomas' Hospital
Lambeth Palace Road
London
SE1 7EH
United Kingdom

Additional identifiers

EudraCT number

ClinicalTrials.gov number

Protocol/serial number

RJ1 05/0083

Study information

Scientific title

Acronym

Study hypothesis

There is an assumption, which has not been tested, that quicker detection of methicillin-resistant Staphylococcus aureus (MRSA) carriers will lead to lower transmission within hospitals. Technology to obtain results more rapidly is being developed. Currently a new, polymerase chain reaction (PCR) based method of MRSA detection provides a screening tool that is much faster but also more expensive than standard methods. We propose to investigate whether significantly faster detection of MRSA cases does lead to reduction in transmission and other adverse outcomes by means of a randomised, crossover trial on both medical and surgical wards.

Ethics approval

Ethics approval received from the local medical ethics committee (ref: 05/Q0702/157)

Study design

A randomised, controlled crossover trial (non-blinded)

Primary study design

Interventional

Secondary study design

Randomised controlled trial

Trial setting

Hospitals

Trial type

Screening

Patient information sheet

Condition

MRSA colonisation (infection and bacteraemia)

Intervention

The use of a rapid method in detecting MRSA. This will be compared against the currently employed non-rapid method of detection.

Intervention type

Other

Phase

Not Specified

Drug names

Primary outcome measures

Ward MRSA transmission rates.

Secondary outcome measures

1. Ward MRSA bacteraemia rates
2. Ward MRSA clinical infection rates
3. Length of hospital stay
4. Use of isolation facilities
5. MRSA-related nursing workload
6. Rapid test sensitivity, specificity, positive predictive value, negative predictive value, turn around time and cost with the conventional method using screening swabs taken under routine conditions
7. Economic analysis

Overall trial start date

01/01/2006

Overall trial end date

01/04/2007

Reason abandoned

Eligibility

Participant inclusion criteria

All patients admitted to 10 study wards in the duration of the study.

Participant type

Patient

Age group

Adult

Gender

Both

Target number of participants

Approximately 15,000

Participant exclusion criteria

Patients not wishing to participate in the study.

Recruitment start date

01/01/2006

Recruitment end date

01/04/2007

Locations

Countries of recruitment

United Kingdom

Trial participating centre

Department of Infection
London
SE1 7EH
United Kingdom

Sponsor information

Organisation

Guy's and St.Thomas' NHS Foundation Trust (UK)

Sponsor details

Dr. Kate Blake
West Wing
Guy's Hospital
St. Thomas' Street
London
SE1 9RT
United Kingdom

Sponsor type

Government

Website

http://www.guysandstthomas.nhs.uk

Funders

Funder type

Government

Funder name

Department of Health (UK) (ref: 0190016)

Alternative name(s)

Funding Body Type

Funding Body Subtype

Location

Results and Publications

Publication and dissemination plan

Not provided at time of registration

Intention to publish date

Participant level data

Not provided at time of registration

Results - basic reporting

Publication summary

Results in http://www.ncbi.nlm.nih.gov/pubmed/18417521

Publication citations

  1. Results

    Jeyaratnam D, Whitty CJ, Phillips K, Liu D, Orezzi C, Ajoku U, French GL, Impact of rapid screening tests on acquisition of meticillin resistant Staphylococcus aureus: cluster randomised crossover trial., BMJ, 2008, 336, 7650, 927-930, doi: 10.1136/bmj.39525.579063.BE.

Additional files

Editorial Notes