Cryotherapy versus Salicylic Acid with Monochloracetic Acid for the Treatment of Verrucae: A Randomised Controlled Trial

ISRCTN	ISRCTN78267267
DOI	https://doi.org/10.1186/ISRCTN78267267
Secondary identifying numbers	N0530132857

Submission date: 30/09/2004
Registration date: 30/09/2004
Last edited: 27/09/2011

Recruitment status: Stopped
Overall study status: Stopped
Condition category: Skin and Connective Tissue Diseases

Prospectively registered

Protocol

Statistical analysis plan

Results

Individual participant data

Record updated in last year

Plain English summary of protocol

Not provided at time of registration

Contact information

Miss Julie C Day
Scientific

Podiatry Department
First Floor East Wing
St Pancras Hospital
4 St Pancras Way
London
NW1 0PE
United Kingdom

Phone	+44 (0)20 7530 3871
Email	jules.day@virgin.net

Study information

Study design	Randomised controlled trial
Primary study design	Interventional
Secondary study design	Randomised controlled trial
Study setting(s)	Not specified
Study type	Not Specified
Scientific title
Study objectives	Verrucae, or warts, are a common, infectious and sometimes painful problem, but it is uncertain which is the most effective treatment. We plan to compare two commonly used treatments for warts: salicylic acid with monochloracetic acid or cryotherapy. We are interested to know how effective the two treatments are in cleaning up the warts and also how cost effective the two treatments are compared to one another. Patients will also be asked about acceptability with their treatment and possible side effects such as pain.
Ethics approval(s)	Not provided at time of registration
Health condition(s) or problem(s) studied	Skin and Connective Tissue Diseases: Warts
Intervention	Database analysis, Questionnaires, Randomised Controlled Trial - to compare: 1. Cryotherapy 2. Salicylic acid with monochloracetic acid For treatment of plantar warts August 2008: Trial stopped 2006.
Intervention type	Drug
Pharmaceutical study type(s)
Phase	Not Specified
Drug / device / biological / vaccine name(s)	Salicylic Acid with Monochloracetic Acid
Primary outcome measure	A recent systematic review has highlighted the uncertainty with respect to the optimal treatment of verrucae and warts (Gibbs Set et al, BMJ, 2002). Freezing warts using cryotherapy is widespread but there is little evidence showing it is effective. However, it may be relatively cost effective compared with chemical treatments in that fewer visits may be required to eradicate the condition. There is a need for a randomised controlled trial with a cost effectiveness analysis to ascertain which is the best approach. The evidence base would aid clinical decision makers and also health care managers in resource allocation
Secondary outcome measures	Not provided at time of registration
Overall study start date	29/10/2003
Completion date	31/08/2004
Reason abandoned (if study stopped)	Problems with staffing.

Eligibility

Participant type(s)	Patient
Age group	Not Specified
Sex	Not Specified
Target number of participants	133 in each treatment group
Key inclusion criteria	Not provided at time of registration
Key exclusion criteria	Not provided at time of registration
Date of first enrolment	29/10/2003
Date of final enrolment	31/08/2004

Locations

Countries of recruitment

England
United Kingdom

Study participating centre

Podiatry Department

London
NW1 0PE
United Kingdom

Sponsor information

Department of Health
Government

Richmond House
79 Whitehall
London
SW1A 2NL
United Kingdom

Website	http://www.dh.gov.uk/Home/fs/en

Funders

Funder type

Research organisation

North Central London Research Consortium (UK)

No information available

Results and Publications

Intention to publish date
Individual participant data (IPD) Intention to share	No
IPD sharing plan summary	Not provided at time of registration
Publication and dissemination plan	Not provided at time of registration
IPD sharing plan