Additional identifiers
EudraCT number
ClinicalTrials.gov number
Protocol/serial number
NAG9402
Study information
Scientific title
Acronym
Study hypothesis
Not provided at time of registration
Ethics approval
Not provided at time of registration
Study design
Randomised controlled trial
Primary study design
Interventional
Secondary study design
Randomised controlled trial
Trial setting
Not specified
Trial type
Not Specified
Patient information sheet
Not available in web format, please use the contact details below to request a patient information sheet
Condition
Cancer of brain and nervous system
Intervention
Patients receiving two courses of carboplatin are randomised to one of two groups:
1. Group A: Surface area based (course I) followed by renal function based (course II) measurement.
2. Group B: Renal function based (course I) followed by surface area based (course II) measurement.
Intervention type
Other
Phase
Not Specified
Drug names
Primary outcome measures
Not provided at time of registration
Secondary outcome measures
Not provided at time of registration
Overall trial start date
01/01/1993
Overall trial end date
28/02/1997
Reason abandoned
Eligibility
Participant inclusion criteria
1. Aged under 18 years
2. Receiving carboplatin on at least two occasions
3. Being treated according to listed UKCCSG protocols (NB9001, NB9301, NB8702, GC8901, CNS9204, CNS9102, WAG8702)
4. Tumour site: Neuroblastoma; Extra-cranial germ cell; Brain
Participant type
Patient
Age group
Child
Gender
Not Specified
Target number of participants
Not provided at time of registration
Participant exclusion criteria
Not provided at time of registration
Recruitment start date
01/01/1993
Recruitment end date
28/02/1997
Locations
Countries of recruitment
United Kingdom
Trial participating centre
UKCCCR Register Co-ordinator
London
NW1 2DA
United Kingdom
Sponsor information
Organisation
Cancer Research UK (CRUK) (UK)
Sponsor details
PO Box 123
Lincoln's Inn Fields
London
WC2A 3PX
United Kingdom
+44 (0)207 317 5186
kate.law@cancer.org.uk
Sponsor type
Charity
Website
Funders
Funder type
Charity
Funder name
Cancer Research UK
Alternative name(s)
CRUK
Funding Body Type
private sector organisation
Funding Body Subtype
other non-profit
Location
United Kingdom
Funder name
United Kingdom Children's Cancer Study Group (UKCCSG)
Alternative name(s)
Funding Body Type
Funding Body Subtype
Location
Results and Publications
Publication and dissemination plan
Not provided at time of registration
Intention to publish date
Participant level data
Not provided at time of registration
Results - basic reporting
Publication summary
1. 2000 results in http://www.ncbi.nlm.nih.gov/pubmed/11054434
Publication citations
-
Results
Thomas H, Boddy AV, English MW, Hobson R, Imeson J, Lewis I, Morland B, Pearson AD, Pinkerton R, Price L, Stevens M, Newell DR, Prospective validation of renal function-based carboplatin dosing in children with cancer: A United Kingdom Children's Cancer Study Group Trial., J. Clin. Oncol., 2000, 18, 21, 3614-3621.